Gene description for AP2S1
Gene name
adaptor-related protein complex 2, sigma 1 subunit
Gene symbol
AP2S1
Other names/aliases
AP17 CLAPS2 FBH3 FBHOk HHC3
Species
Homo sapiens
Database cross references - AP2S1
ExoCarta
ExoCarta_1175
Entrez Gene
1175
HGNC
565
MIM
602242
UniProt
P53680
AP2S1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells
25944692
Thymus
23844026
Gene ontology annotations for AP2S1
Experiment description of studies that identified AP2S1 in exosomes
1
Experiment ID
224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25944692
Organism
Homo sapiens
Experiment description
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors
Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name
Oncotarget
Publication year
2015
Sample
Neuroblastoma cells
Sample name
SH-SY5Y
Isolation/purification methods
Differential centrifugation Ultracentrifugation OptiPrep density gradient
Flotation density
1.10 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry Western blotting
2
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for AP2S1
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
RAB25
57111
Affinity Capture-MS
Homo sapiens
2
POLQ
Affinity Capture-MS
Homo sapiens
3
AP2B1
163
Affinity Capture-MS
Homo sapiens
Invitro
Homo sapiens
4
PAK7
Affinity Capture-MS
Homo sapiens
5
KHK
3795
Affinity Capture-MS
Homo sapiens
6
AP2A1
160
Affinity Capture-MS
Homo sapiens
Two-hybrid
Homo sapiens
View the network
image/svg+xml
Pathways in which AP2S1 is involved