Gene description for FCHO2
Gene name FCH domain only 2
Gene symbol FCHO2
Other names/aliases -
Species Homo sapiens
 Database cross references - FCHO2
ExoCarta ExoCarta_115548
Vesiclepedia VP_115548
Entrez Gene 115548
HGNC 25180
MIM 613438
UniProt Q0JRZ9  
 FCHO2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FCHO2
Molecular Function
    phosphatidylserine binding GO:0001786 ISS
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS
    phosphatidylinositol binding GO:0035091 ISS
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 IPI
Biological Process
    membrane invagination GO:0010324 ISS
    clathrin coat assembly GO:0048268 IBA
    clathrin coat assembly GO:0048268 IMP
    synaptic vesicle endocytosis GO:0048488 IBA
    clathrin-dependent endocytosis GO:0072583 IBA
    clathrin-dependent endocytosis GO:0072583 IMP
    protein localization to plasma membrane GO:0072659 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    clathrin-coated pit GO:0005905 IBA
    clathrin-coated pit GO:0005905 IDA
    clathrin-coated vesicle GO:0030136 IBA
    clathrin-coated vesicle GO:0030136 IDA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified FCHO2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FCHO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRG 5793
Proximity Label-MS Homo sapiens
2 GTSE1 51512
Affinity Capture-MS Homo sapiens
3 LIMA1 51474
Affinity Capture-MS Homo sapiens
4 RAB35 11021
Proximity Label-MS Homo sapiens
5 FASN 2194
Negative Genetic Homo sapiens
6 RHOU 58480
Reconstituted Complex Homo sapiens
7 DAB2 1601
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
8 Myh9 17886
Affinity Capture-MS Mus musculus
9 Lima1  
Affinity Capture-MS Mus musculus
10 LAMTOR1 55004
Proximity Label-MS Homo sapiens
11 AP2S1 1175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LAMP3  
Proximity Label-MS Homo sapiens
13 XPO1 7514
Affinity Capture-MS Homo sapiens
14 GJA1 2697
Proximity Label-MS Homo sapiens
15 AGO2 27161
Affinity Capture-RNA Homo sapiens
16 PFN1 5216
Proximity Label-MS Homo sapiens
17 ATG9A 79065
Proximity Label-MS Homo sapiens
18 LAMP1 3916
Proximity Label-MS Homo sapiens
19 Myo1c 17913
Affinity Capture-MS Mus musculus
20 DBN1 1627
Affinity Capture-MS Homo sapiens
21 FCHO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 MIB1 57534
Proximity Label-MS Homo sapiens
23 EPS15 2060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
24 CAPZA2 830
Affinity Capture-MS Homo sapiens
25 UBC 7316
Reconstituted Complex Homo sapiens
26 LAMP2 3920
Proximity Label-MS Homo sapiens
27 MYO19  
Affinity Capture-MS Homo sapiens
28 ARF6 382
Proximity Label-MS Homo sapiens
29 Actb 11461
Affinity Capture-MS Mus musculus
30 CLTB 1212
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
31 DDX58 23586
Affinity Capture-RNA Homo sapiens
32 OCLN 100506658
Proximity Label-MS Homo sapiens
33 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LYN 4067
Proximity Label-MS Homo sapiens
35 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 SPC25 57405
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 AP2B1 163
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 KRAS 3845
Proximity Label-MS Homo sapiens
39 Flnb 286940
Affinity Capture-MS Mus musculus
40 LDLR 3949
Negative Genetic Homo sapiens
41 MYH9 4627
Affinity Capture-MS Homo sapiens
42 MACC1 346389
Affinity Capture-MS Homo sapiens
43 CLTA 1211
Proximity Label-MS Homo sapiens
44 AP1B1 162
Affinity Capture-MS Homo sapiens
45 EPHA2 1969
Proximity Label-MS Homo sapiens
46 BICD2 23299
Proximity Label-MS Homo sapiens
47 MYO6 4646
Proximity Label-MS Homo sapiens
48 RHOB 388
Proximity Label-MS Homo sapiens
49 CLTC 1213
Affinity Capture-MS Homo sapiens
50 C11orf52 91894
Proximity Label-MS Homo sapiens
51 PICALM 8301
Affinity Capture-MS Homo sapiens
52 EPS15L1 58513
Affinity Capture-MS Homo sapiens
53 ANK3  
Proximity Label-MS Homo sapiens
54 DIRAS3  
Proximity Label-MS Homo sapiens
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