Gene description for PTPRG
Gene name protein tyrosine phosphatase, receptor type, G
Gene symbol PTPRG
Other names/aliases HPTPG
PTPG
R-PTP-GAMMA
RPTPG
Species Homo sapiens
 Database cross references - PTPRG
ExoCarta ExoCarta_5793
Entrez Gene 5793
HGNC 9671
MIM 176886
UniProt P23470  
 PTPRG identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PTPRG
Molecular Function
    transmembrane receptor protein tyrosine phosphatase activity GO:0005001 TAS
    protein tyrosine phosphatase activity GO:0004725 IDA
    identical protein binding GO:0042802 IPI
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of neuron projection development GO:0010977 IEA
    negative regulation of epithelial cell migration GO:0010633 IMP
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS
    peptidyl-tyrosine dephosphorylation GO:0035335 TAS
    brain development GO:0007420 IEA
    regulation of homophilic cell adhesion GO:1903385 IMP
    toxin transport GO:1901998 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IEA
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified PTPRG in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPRG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DLG4  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PTPRG is involved
No pathways found





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