Gene description for CSF3
Gene name colony stimulating factor 3 (granulocyte)
Gene symbol CSF3
Other names/aliases C17orf33
CSF3OS
GCSF
Species Homo sapiens
 Database cross references - CSF3
ExoCarta ExoCarta_1440
Vesiclepedia VP_1440
Entrez Gene 1440
HGNC 2438
MIM 138970
UniProt P09919  
 CSF3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CSF3
Molecular Function
    growth factor activity GO:0008083 IEA
    granulocyte colony-stimulating factor receptor binding GO:0005130 TAS
    enzyme binding GO:0019899 IPI
    cytokine activity GO:0005125 NAS
Biological Process
    cytokine-mediated signaling pathway GO:0019221 NAS
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA
    positive regulation of myeloid cell differentiation GO:0045639 IEA
    positive regulation of protein kinase B signaling GO:0051897 IDA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    multicellular organismal development GO:0007275 TAS
    positive regulation of cell proliferation GO:0008284 IEA
    cellular response to cytokine stimulus GO:0071345 IDA
    cellular response to lipopolysaccharide GO:0071222 IEA
    positive regulation of transcription factor import into nucleus GO:0042993 IDA
    positive regulation of actin filament polymerization GO:0030838 IDA
    positive regulation of protein binding GO:0032092 IDA
    negative regulation of neuron death GO:1901215 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    positive regulation of actin cytoskeleton reorganization GO:2000251 IDA
    granulocyte differentiation GO:0030851 NAS
    immune response GO:0006955 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified CSF3 in exosomes
1
Experiment ID 126
MISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CSF3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CSF3 is involved
No pathways found





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