Gene description for TBX3
Gene name T-box 3
Gene symbol TBX3
Other names/aliases TBX3-ISO
UMS
XHL
Species Homo sapiens
 Database cross references - TBX3
ExoCarta ExoCarta_6926
Vesiclepedia VP_6926
Entrez Gene 6926
HGNC 11602
MIM 601621
UniProt O15119  
 TBX3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TBX3
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    sequence-specific DNA binding GO:0043565 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IDA
    RNA polymerase II activating transcription factor binding GO:0001102 ISS
    protein binding GO:0005515 IPI
    RNA polymerase II transcription factor binding GO:0001085 ISS
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    negative regulation of myoblast differentiation GO:0045662 IDA
    mammary gland development GO:0030879 IMP
    skeletal system development GO:0001501 IMP
    sinoatrial node cell development GO:0060931 IEA
    heart looping GO:0001947 IEA
    positive regulation of cell proliferation GO:0008284 IDA
    luteinizing hormone secretion GO:0032275 IMP
    blood vessel development GO:0001568 IEA
    male genitalia development GO:0030539 IMP
    palate development GO:0060021 IEA
    positive regulation of cell cycle GO:0045787 IDA
    mammary placode formation GO:0060596 IEA
    outflow tract morphogenesis GO:0003151 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    embryonic forelimb morphogenesis GO:0035115 IMP
    atrioventricular bundle cell differentiation GO:0003167 IEA
    transcription, DNA-templated GO:0006351 IEA
    cellular senescence GO:0090398 IDA
    in utero embryonic development GO:0001701 IEA
    embryonic digit morphogenesis GO:0042733 IMP
    ventricular septum morphogenesis GO:0060412 IEA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    mesoderm morphogenesis GO:0048332 IMP
    stem cell maintenance GO:0019827 IEA
    specification of organ position GO:0010159 IEA
    forelimb morphogenesis GO:0035136 IDA
    negative regulation of apoptotic process GO:0043066 IDA
    positive regulation of stem cell proliferation GO:2000648 IEA
    female genitalia development GO:0030540 IMP
    negative regulation of epithelial cell differentiation GO:0030857 IEA
    organ morphogenesis GO:0009887 IDA
    follicle-stimulating hormone secretion GO:0046884 IMP
    cell aging GO:0007569 IDA
    anterior/posterior axis specification, embryo GO:0008595 IMP
    cardiac muscle cell fate commitment GO:0060923 IEA
    branching involved in mammary gland duct morphogenesis GO:0060444 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IEA
    limbic system development GO:0021761 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
 Experiment description of studies that identified TBX3 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 235
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for TBX3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TBX3 6926
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which TBX3 is involved
No pathways found





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