Gene description for PLEKHF2
Gene name pleckstrin homology domain containing, family F (with FYVE domain) member 2
Gene symbol PLEKHF2
Other names/aliases EAPF
PHAFIN2
ZFYVE18
Species Homo sapiens
 Database cross references - PLEKHF2
ExoCarta ExoCarta_79666
Entrez Gene 79666
HGNC 20757
MIM 615208
UniProt Q9H8W4  
 PLEKHF2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PLEKHF2
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
Biological Process
    protein transport GO:0015031 IEA
Subcellular Localization
    transport vesicle GO:0030133 IDA
    endoplasmic reticulum GO:0005783 IEA
    early endosome membrane GO:0031901 IEA
 Experiment description of studies that identified PLEKHF2 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLEKHF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DIPA  
Two-hybrid Homo sapiens
2 NONO 4841
Two-hybrid Homo sapiens
3 SFN 2810
Two-hybrid Homo sapiens
4 CHIC2  
Two-hybrid Homo sapiens
5 MBIP  
Two-hybrid Homo sapiens
6 PRKAR1A 5573
Two-hybrid Homo sapiens
7 UBE2Z 65264
Two-hybrid Homo sapiens
8 TSC22D3  
Two-hybrid Homo sapiens
9 SPEF1  
Two-hybrid Homo sapiens
10 PLDN  
Two-hybrid Homo sapiens
11 SP192  
Two-hybrid Homo sapiens
12 GLUL 2752
Two-hybrid Homo sapiens
13 SDPR 8436
Two-hybrid Homo sapiens
14 GNMT  
Two-hybrid Homo sapiens
15 RTN1  
Two-hybrid Homo sapiens
16 MAX  
Two-hybrid Homo sapiens
17 PRPSAP1 5635
Two-hybrid Homo sapiens
18 ZNF263  
Two-hybrid Homo sapiens
19 RABAC1  
Two-hybrid Homo sapiens
20 RTN3 10313
Two-hybrid Homo sapiens
21 RTN4 57142
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PLEKHF2 is involved
No pathways found





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