Gene description for PLEKHF2
Gene name pleckstrin homology domain containing, family F (with FYVE domain) member 2
Gene symbol PLEKHF2
Other names/aliases EAPF
PHAFIN2
ZFYVE18
Species Homo sapiens
 Database cross references - PLEKHF2
ExoCarta ExoCarta_79666
Vesiclepedia VP_79666
Entrez Gene 79666
HGNC 20757
MIM 615208
UniProt Q9H8W4  
 PLEKHF2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PLEKHF2
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    endosome organization GO:0007032 IBA
    endosome to lysosome transport GO:0008333 IBA
    protein transport GO:0015031 IEA
Subcellular Localization
    early endosome GO:0005769 IBA
    endoplasmic reticulum GO:0005783 IEA
    transport vesicle GO:0030133 IDA
    early endosome membrane GO:0031901 IEA
 Experiment description of studies that identified PLEKHF2 in exosomes
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLEKHF2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AIDA 64853
Two-hybrid Homo sapiens
2 SAMD11  
Two-hybrid Homo sapiens
3 XCR1  
Two-hybrid Homo sapiens
4 GNMT 27232
Two-hybrid Homo sapiens
5 HSPB7  
Two-hybrid Homo sapiens
6 BLOC1S6  
Two-hybrid Homo sapiens
7 PACSIN1  
Two-hybrid Homo sapiens
8 HSPA6 3310
Co-fractionation Homo sapiens
9 EML2 24139
Two-hybrid Homo sapiens
10 TRIAP1  
Two-hybrid Homo sapiens
11 CRYBA1  
Two-hybrid Homo sapiens
12 SCYL1 57410
Two-hybrid Homo sapiens
13 NUDT2 318
Two-hybrid Homo sapiens
14 KRTAP5-4  
Two-hybrid Homo sapiens
15 THOC2 57187
Affinity Capture-MS Homo sapiens
16 BSCL2  
Two-hybrid Homo sapiens
17 SEPT5 5413
Two-hybrid Homo sapiens
18 ARL14EP  
Two-hybrid Homo sapiens
19 ZNF439  
Two-hybrid Homo sapiens
20 ZNF398  
Two-hybrid Homo sapiens
21 ASPH 444
Two-hybrid Homo sapiens
22 RTN4 57142
Two-hybrid Homo sapiens
23 APP 351
Reconstituted Complex Homo sapiens
24 MIDN 90007
Two-hybrid Homo sapiens
25 FRMD8 83786
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
26 DPPA4  
Two-hybrid Homo sapiens
27 NPM2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 MBIP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 MEAF6  
Two-hybrid Homo sapiens
30 RPRM  
Two-hybrid Homo sapiens
31 C3 718
Two-hybrid Homo sapiens
32 CHCHD2  
Two-hybrid Homo sapiens
33 BARHL2  
Two-hybrid Homo sapiens
34 PPP1R18 170954
Two-hybrid Homo sapiens
35 KRTAP10-10  
Two-hybrid Homo sapiens
36 ABCG4  
Two-hybrid Homo sapiens
37 NDUFA5 4698
Two-hybrid Homo sapiens
38 FBXO28  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 ANO9  
Two-hybrid Homo sapiens
40 SOST  
Two-hybrid Homo sapiens
41 BOD1  
Two-hybrid Homo sapiens
42 RTN1 6252
Two-hybrid Homo sapiens
43 GAGE2E 26749
Two-hybrid Homo sapiens
44 PAK1IP1  
Two-hybrid Homo sapiens
45 MBP 4155
Two-hybrid Homo sapiens
46 THAP10  
Two-hybrid Homo sapiens
47 SFN 2810
Two-hybrid Homo sapiens
48 PPCDC  
Two-hybrid Homo sapiens
49 TCEANC  
Two-hybrid Homo sapiens
50 EXOC7 23265
Two-hybrid Homo sapiens
51 FBXW5  
Two-hybrid Homo sapiens
52 UGP2 7360
Two-hybrid Homo sapiens
53 YWHAB 7529
Co-fractionation Homo sapiens
54 CCDC172  
Two-hybrid Homo sapiens
55 GSTM3 2947
Co-fractionation Homo sapiens
56 TXNL4B  
Two-hybrid Homo sapiens
57 SPATA24  
Two-hybrid Homo sapiens
58 FHL3 2275
Two-hybrid Homo sapiens
59 WHSC1 7468
Two-hybrid Homo sapiens
60 GAGE12G  
Two-hybrid Homo sapiens
61 TNFAIP8 25816
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 NONO 4841
Two-hybrid Homo sapiens
63 PRKAG1 5571
Two-hybrid Homo sapiens
64 RPE  
Two-hybrid Homo sapiens
65 DAZAP2  
Two-hybrid Homo sapiens
66 BCAS3 54828
Two-hybrid Homo sapiens
67 GEM  
Two-hybrid Homo sapiens
68 NFIA 4774
Two-hybrid Homo sapiens
69 DRAP1 10589
Two-hybrid Homo sapiens
70 DTX2 113878
Two-hybrid Homo sapiens
71 EEF1E1 9521
Co-fractionation Homo sapiens
72 ACY3 91703
Two-hybrid Homo sapiens
73 THG1L 54974
Two-hybrid Homo sapiens
74 GPBP1L1  
Two-hybrid Homo sapiens
75 ZNF581  
Two-hybrid Homo sapiens
76 RGS10 6001
Two-hybrid Homo sapiens
77 RGS8  
Two-hybrid Homo sapiens
78 YIF1A 10897
Two-hybrid Homo sapiens
79 SDPR 8436
Two-hybrid Homo sapiens
80 FGF13  
Two-hybrid Homo sapiens
81 AIMP2 7965
Two-hybrid Homo sapiens
82 SEPT6 23157
Two-hybrid Homo sapiens
83 CCDC25 55246
Two-hybrid Homo sapiens
84 CGGBP1 8545
Two-hybrid Homo sapiens
85 BRD7  
Two-hybrid Homo sapiens
86 TNFAIP8L1  
Two-hybrid Homo sapiens
87 COX5B 1329
Two-hybrid Homo sapiens
88 LRRC6  
Two-hybrid Homo sapiens
89 GFER  
Two-hybrid Homo sapiens
90 C11orf45  
Two-hybrid Homo sapiens
91 FLNA 2316
Two-hybrid Homo sapiens
92 SNRNP35  
Two-hybrid Homo sapiens
93 CBX8 57332
Two-hybrid Homo sapiens
94 FAH 2184
Two-hybrid Homo sapiens
95 RASGEF1B  
Two-hybrid Homo sapiens
96 UBE2Z 65264
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
97 PRKAR1A 5573
Two-hybrid Homo sapiens
98 TRAF6 7189
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 MAGI2  
Two-hybrid Homo sapiens
100 ZNF250  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
101 YY1 7528
Two-hybrid Homo sapiens
102 SEC14L4 284904
Two-hybrid Homo sapiens
103 PRPSAP1 5635
Two-hybrid Homo sapiens
104 RSPO2  
Two-hybrid Homo sapiens
105 SETBP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
106 SEPT2 4735
Two-hybrid Homo sapiens
107 L3MBTL3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
108 MFAP1  
Two-hybrid Homo sapiens
109 RABAC1 10567
Two-hybrid Homo sapiens
110 CCDC85B  
Two-hybrid Homo sapiens
111 TRIM22 10346
Two-hybrid Homo sapiens
112 INO80  
Two-hybrid Homo sapiens
113 ZBTB6  
Two-hybrid Homo sapiens
114 TTC9C 283237
Two-hybrid Homo sapiens
115 LDOC1  
Two-hybrid Homo sapiens
116 GPBP1  
Two-hybrid Homo sapiens
117 CDC20B  
Two-hybrid Homo sapiens
118 RAB28 9364
Two-hybrid Homo sapiens
119 STAMBPL1  
Two-hybrid Homo sapiens
120 TSC22D3  
Two-hybrid Homo sapiens
121 S100A13 6284
Two-hybrid Homo sapiens
122 ZNF263  
Two-hybrid Homo sapiens
123 CXorf57  
Two-hybrid Homo sapiens
124 TBX3 6926
Two-hybrid Homo sapiens
125 NUTM1  
Two-hybrid Homo sapiens
126 S100A1 6271
Two-hybrid Homo sapiens
127 TP53BP2  
Two-hybrid Homo sapiens
128 RARA 5914
Two-hybrid Homo sapiens
129 BCAS2 10286
Two-hybrid Homo sapiens
130 DOCK2 1794
Two-hybrid Homo sapiens
131 EIF3C 8663
Two-hybrid Homo sapiens
132 MAX  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
133 PRDM14  
Two-hybrid Homo sapiens
134 RTN3 10313
Two-hybrid Homo sapiens
135 ZDHHC24  
Two-hybrid Homo sapiens
136 CCDC146  
Two-hybrid Homo sapiens
137 RPS21 6227
Two-hybrid Homo sapiens
138 RPAP2  
Two-hybrid Homo sapiens
139 C1orf35  
Two-hybrid Homo sapiens
140 TBCEL 219899
Two-hybrid Homo sapiens
141 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
142 SHMT2 6472
Affinity Capture-RNA Homo sapiens
143 MAP2K1 5604
Two-hybrid Homo sapiens
144 CEP44  
Two-hybrid Homo sapiens
145 SYT16  
Two-hybrid Homo sapiens
146 CHIC2 26511
Two-hybrid Homo sapiens
147 MOV10 4343
Affinity Capture-RNA Homo sapiens
148 GLUL 2752
Two-hybrid Homo sapiens
149 SPON2 10417
Two-hybrid Homo sapiens
150 ADAP1  
Two-hybrid Homo sapiens
151 TRAPPC3 27095
Two-hybrid Homo sapiens
152 DUSP4 1846
Two-hybrid Homo sapiens
153 USF1  
Two-hybrid Homo sapiens
154 SPEF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
155 PWWP2A  
Two-hybrid Homo sapiens
156 GTPBP2 54676
Two-hybrid Homo sapiens
157 KCNAB3  
Two-hybrid Homo sapiens
158 ZNF165  
Two-hybrid Homo sapiens
159 TRAM1L1  
Two-hybrid Homo sapiens
160 PIK3R3 8503
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PLEKHF2 is involved
No pathways found





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