Gene description for S100A1
Gene name S100 calcium binding protein A1
Gene symbol S100A1
Other names/aliases S100
S100-alpha
S100A
Species Homo sapiens
 Database cross references - S100A1
ExoCarta ExoCarta_6271
Vesiclepedia VP_6271
Entrez Gene 6271
HGNC 10486
MIM 176940
UniProt P23297  
 S100A1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for S100A1
Molecular Function
    calcium-dependent protein binding GO:0048306 IEA
    protein binding GO:0005515 IPI
    ATPase binding GO:0051117 IPI
    protein homodimerization activity GO:0042803 IDA
    calcium ion binding GO:0005509 IEA
    S100 protein binding GO:0044548 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    positive regulation of voltage-gated calcium channel activity GO:1901387 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    intracellular signal transduction GO:0035556 NAS
    regulation of heart contraction GO:0008016 NAS
    substantia nigra development GO:0021762 IEP
Subcellular Localization
    M band GO:0031430 IEA
    Z disc GO:0030018 IEA
    protein complex GO:0043234 NAS
    nucleus GO:0005634 IDA
    neuron projection GO:0043005 IEA
    sarcoplasmic reticulum GO:0016529 IDA
 Experiment description of studies that identified S100A1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for S100A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 S100A4 6275
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 S100B 6285
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 PGM1 5236
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
4 ATP2A2 488
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
5 RYR1 6261
Invitro Homo sapiens
6 S100A1 6271
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 PLN  
Affinity Capture-MS Homo sapiens
8 PLB1  
Affinity Capture-Western Homo sapiens
9 DES 1674
Invitro Homo sapiens
10 CAPZA1 829
Invitro Homo sapiens
11 NIF3L1 60491
Two-hybrid Homo sapiens
12 GFAP 2670
Affinity Capture-MS Homo sapiens
13 ANXA6 309
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
14 S100P 6286
Two-hybrid Homo sapiens
15 PYGM 5837
Affinity Capture-Western Homo sapiens
16 GJA1 2697
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
17 CACYBP 27101
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which S100A1 is involved
No pathways found





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