Gene description for DES
Gene name desmin
Gene symbol DES
Other names/aliases CSM1
CSM2
LGMD2R
Species Homo sapiens
 Database cross references - DES
ExoCarta ExoCarta_1674
Entrez Gene 1674
HGNC 2770
MIM 125660
UniProt P17661  
 DES identified in exosomes derived from the following tissue/cell type
Liver cancer cells 25265333    
 Gene ontology annotations for DES
Molecular Function
    cytoskeletal protein binding GO:0008092 IPI
    identical protein binding GO:0042802 IPI
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of heart contraction GO:0008016 TAS
    muscle filament sliding GO:0030049 TAS
    cytoskeleton organization GO:0007010 TAS
    muscle contraction GO:0006936 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    sarcolemma GO:0042383 IDA
    extracellular exosome GO:0070062 IDA
    Z disc GO:0030018 IDA
    intermediate filament GO:0005882 IEA
    neuromuscular junction GO:0031594 IEA
    fascia adherens GO:0005916 IEA
 Experiment description of studies that identified DES in exosomes
1
Experiment ID 267
ISEV standards
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EV Membrane markers
CANX|HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh‑7 Cells Using SILAC Labeling and LC−MS/MS
Authors Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for DES
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYNC1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 S100A1  
Invitro Homo sapiens
3 SPTAN1 6709
Co-purification Homo sapiens
4 NEB 4703
Two-hybrid Homo sapiens
5 SYNM 23336
Reconstituted Complex Homo sapiens
6 DSP 1832
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DES is involved
PathwayEvidenceSource
Striated Muscle Contraction TAS Reactome





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