Gene description for DES
Gene name desmin
Gene symbol DES
Other names/aliases CSM1
CSM2
LGMD2R
Species Homo sapiens
 Database cross references - DES
ExoCarta ExoCarta_1674
Entrez Gene 1674
HGNC 2770
MIM 125660
UniProt P17661  
 DES identified in exosomes derived from the following tissue/cell type
Liver cancer cells 25265333    
 Gene ontology annotations for DES
Molecular Function
    cytoskeletal protein binding GO:0008092 IPI
    identical protein binding GO:0042802 IPI
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of heart contraction GO:0008016 TAS
    muscle filament sliding GO:0030049 TAS
    cytoskeleton organization GO:0007010 TAS
    muscle contraction GO:0006936 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    sarcolemma GO:0042383 IDA
    extracellular exosome GO:0070062 IDA
    Z disc GO:0030018 IDA
    intermediate filament GO:0005882 IEA
    neuromuscular junction GO:0031594 IEA
    fascia adherens GO:0005916 IEA
 Experiment description of studies that identified DES in exosomes
1
Experiment ID 267
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✘ EV Membrane markers
✔
CANX|HSP90B1
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh‑7 Cells Using SILAC Labeling and LC−MS/MS
Authors Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for DES
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SYNC1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 S100A1  
Invitro Homo sapiens
3 SPTAN1 6709
Co-purification Homo sapiens
4 NEB 4703
Two-hybrid Homo sapiens
5 SYNM 23336
Reconstituted Complex Homo sapiens
6 DSP 1832
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DES is involved
PathwayEvidenceSource
Striated Muscle Contraction TAS Reactome





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