Gene description for SPTAN1
Gene name spectrin, alpha, non-erythrocytic 1
Gene symbol SPTAN1
Other names/aliases EIEE5
NEAS
SPTA2
Species Homo sapiens
 Database cross references - SPTAN1
ExoCarta ExoCarta_6709
Vesiclepedia VP_6709
Entrez Gene 6709
HGNC 11273
MIM 182810
UniProt Q13813  
 SPTAN1 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 19837982    
Colorectal cancer cells 34887515    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for SPTAN1
Molecular Function
    actin binding GO:0003779 TAS
    structural constituent of cytoskeleton GO:0005200 TAS
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
    cadherin binding GO:0045296 HDA
    actin filament binding GO:0051015 IBA
Biological Process
    actin cytoskeleton organization GO:0030036 IBA
    actin filament capping GO:0051693 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    spectrin GO:0008091 TAS
    microtubule cytoskeleton GO:0015630 IDA
    membrane GO:0016020 TAS
    cell junction GO:0030054 IBA
    cortical actin cytoskeleton GO:0030864 IBA
    specific granule lumen GO:0035580 TAS
    cell projection GO:0042995 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular exosome GO:0070062 HDA
    extracellular vesicle GO:1903561 HDA
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified SPTAN1 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
13
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
14
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
15
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
16
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
23
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
24
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
25
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
27
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SPTAN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 KIF14 9928
Affinity Capture-MS Homo sapiens
3 MCM3 4172
Co-fractionation Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 ISG15 9636
Affinity Capture-MS Homo sapiens
6 PPP1CB 5500
Affinity Capture-MS Homo sapiens
7 SPTB 6710
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
8 DDX24 57062
Two-hybrid Homo sapiens
9 SLFN11 91607
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
10 Tpm1 22003
Affinity Capture-MS Mus musculus
11 SHC1 6464
Affinity Capture-MS Homo sapiens
12 POT1  
Affinity Capture-MS Homo sapiens
13 CENPE 1062
Affinity Capture-MS Homo sapiens
14 MARCKS 4082
Proximity Label-MS Homo sapiens
15 SMURF1 57154
Affinity Capture-MS Homo sapiens
16 GJA1 2697
Proximity Label-MS Homo sapiens
17 MTX1 4580
Co-fractionation Homo sapiens
18 RPA2 6118
Affinity Capture-MS Homo sapiens
19 Calml3  
Affinity Capture-MS Mus musculus
20 SOS1 6654
Two-hybrid Homo sapiens
21 ACTC1 70
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
22 DBN1 1627
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
23 HSPA12B 116835
Proximity Label-MS Homo sapiens
24 LIMA1 51474
Affinity Capture-MS Homo sapiens
25 KIF20A 10112
Affinity Capture-MS Homo sapiens
26 HNRNPC 3183
Co-fractionation Homo sapiens
27 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
28 KARS 3735
Two-hybrid Homo sapiens
29 NENF 29937
Co-fractionation Homo sapiens
30 MYO5C 55930
Affinity Capture-MS Homo sapiens
31 HNRNPR 10236
Co-fractionation Homo sapiens
32 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
33 Actb 11461
Affinity Capture-MS Mus musculus
34 ZBTB1  
Affinity Capture-MS Homo sapiens
35 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
36 EVL 51466
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
37 FAU 2197
Co-fractionation Homo sapiens
38 HSPA5 3309
Co-fractionation Homo sapiens
39 ILF2 3608
Co-fractionation Homo sapiens
40 KIAA1429 25962
Affinity Capture-MS Homo sapiens
41 CAPZB 832
Affinity Capture-MS Homo sapiens
42 WDR76  
Affinity Capture-MS Homo sapiens
43 RDX 5962
Proximity Label-MS Homo sapiens
44 B3GNT2 10678
Affinity Capture-MS Homo sapiens
45 CRYZ 1429
Co-fractionation Homo sapiens
46 PRC1 9055
Affinity Capture-MS Homo sapiens
47 PRKCDBP 112464
Co-fractionation Homo sapiens
48 KIF23 9493
Affinity Capture-MS Homo sapiens
49 EXOC1 55763
Two-hybrid Homo sapiens
50 CASP3 836
Biochemical Activity Homo sapiens
51 GPHN 10243
Co-fractionation Homo sapiens
52 CALD1 800
Affinity Capture-MS Homo sapiens
53 COPS5 10987
Affinity Capture-MS Homo sapiens
54 LASP1 3927
Affinity Capture-MS Homo sapiens
55 IQGAP1 8826
Affinity Capture-MS Homo sapiens
56 AGO3  
Affinity Capture-MS Homo sapiens
57 UBL4A 8266
Affinity Capture-MS Homo sapiens
58 CALM3 808
Affinity Capture-MS Homo sapiens
59 ADD1 118
Affinity Capture-MS Homo sapiens
60 C11orf52 91894
Proximity Label-MS Homo sapiens
61 GSPT1 2935
Co-fractionation Homo sapiens
62 RABL2A 11159
Co-fractionation Homo sapiens
63 KRAS 3845
Proximity Label-MS Homo sapiens
64 NELFE 7936
Affinity Capture-MS Homo sapiens
65 Myh9 17886
Affinity Capture-MS Mus musculus
66 STX6 10228
Proximity Label-MS Homo sapiens
67 CEP57  
Affinity Capture-MS Homo sapiens
68 STRIP1 85369
Co-fractionation Homo sapiens
69 METTL14  
Affinity Capture-MS Homo sapiens
70 MECP2 4204
Affinity Capture-MS Homo sapiens
71 NSFL1C 55968
Affinity Capture-MS Homo sapiens
72 CUL1 8454
Affinity Capture-MS Homo sapiens
73 TFCP2 7024
Affinity Capture-MS Homo sapiens
74 STAU1 6780
Affinity Capture-MS Homo sapiens
75 SERBP1 26135
Cross-Linking-MS (XL-MS) Homo sapiens
76 PXDN 7837
Co-fractionation Homo sapiens
77 AKIP1  
Two-hybrid Homo sapiens
78 TES 26136
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
79 Tmed10 68581
Affinity Capture-MS Mus musculus
80 ACTG1 71
Affinity Capture-MS Homo sapiens
81 FANCF  
Affinity Capture-Western Homo sapiens
82 PFN1 5216
Proximity Label-MS Homo sapiens
83 PPM1B 5495
Affinity Capture-MS Homo sapiens
84 ACTA2 59
Co-fractionation Homo sapiens
85 RNF6  
Affinity Capture-MS Homo sapiens
86 MYO18A 399687
Affinity Capture-MS Homo sapiens
87 LMNA 4000
Co-fractionation Homo sapiens
88 NUP188 23511
Co-fractionation Homo sapiens
89 USP10 9100
Affinity Capture-MS Homo sapiens
90 CERS2 29956
Affinity Capture-MS Homo sapiens
91 EMD 2010
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
92 Flot2 14252
Affinity Capture-MS Mus musculus
93 TAF10 6881
Affinity Capture-MS Homo sapiens
94 PARK2  
Affinity Capture-MS Homo sapiens
95 COPE 11316
Affinity Capture-MS Homo sapiens
96 SFXN3 81855
Co-fractionation Homo sapiens
97 OCLN 100506658
Proximity Label-MS Homo sapiens
98 PPT2  
Co-fractionation Homo sapiens
99 LYN 4067
Proximity Label-MS Homo sapiens
100 MAPRE1 22919
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 RNF38  
Affinity Capture-MS Homo sapiens
102 CBL 867
Affinity Capture-MS Homo sapiens
103 RAB4A 5867
Proximity Label-MS Homo sapiens
104 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
105 ACTA1 58
Affinity Capture-Western Homo sapiens
106 DNAJC5 80331
Proximity Label-MS Homo sapiens
107 UBASH3B 84959
Affinity Capture-MS Homo sapiens
108 UBR5 51366
Affinity Capture-MS Homo sapiens
109 CDH1 999
Proximity Label-MS Homo sapiens
110 NCAPD3 23310
Co-fractionation Homo sapiens
111 FANCG 2189
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
112 YAP1 10413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 MYH9 4627
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
114 VCP 7415
Affinity Capture-MS Homo sapiens
115 NTRK1 4914
Affinity Capture-MS Homo sapiens
116 ZNF333  
Two-hybrid Homo sapiens
117 PTP4A2 8073
Affinity Capture-MS Homo sapiens
118 IFI16 3428
Affinity Capture-MS Homo sapiens
119 U2AF2 11338
Affinity Capture-MS Homo sapiens
120 ZSCAN26  
Affinity Capture-MS Homo sapiens
121 LAMP1 3916
Proximity Label-MS Homo sapiens
122 DNAJA1 3301
Co-fractionation Homo sapiens
123 GRIN1 2902
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
124 EPB41L4A 64097
Proximity Label-MS Homo sapiens
125 RPA4  
Proximity Label-MS Homo sapiens
126 ACTB 60
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 CHMP4B 128866
Affinity Capture-MS Homo sapiens
128 DHX9 1660
Co-fractionation Homo sapiens
129 Coro1c 23790
Affinity Capture-MS Mus musculus
130 GRIN2A  
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
131 MAGOH 4116
Affinity Capture-MS Homo sapiens
132 CEP76  
Affinity Capture-MS Homo sapiens
133 ITGB2 3689
Affinity Capture-Western Homo sapiens
134 GAK 2580
Affinity Capture-MS Homo sapiens
135 SARS2 54938
Co-fractionation Homo sapiens
136 CYLD  
Affinity Capture-MS Homo sapiens
137 PPFIA1 8500
Co-fractionation Homo sapiens
138 KIF2A 3796
Co-fractionation Homo sapiens
139 Tes  
Two-hybrid Rattus norvegicus
140 PPP4R1 9989
Co-fractionation Homo sapiens
141 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 NUCB2 4925
Co-fractionation Homo sapiens
143 PHLPP1  
Proximity Label-MS Homo sapiens
144 DISC1 27185
Two-hybrid Homo sapiens
145 ACTN1 87
Co-fractionation Homo sapiens
146 GAN 8139
Affinity Capture-MS Homo sapiens
147 PTOV1  
Two-hybrid Homo sapiens
148 SPTBN4 57731
Two-hybrid Homo sapiens
149 RNF219  
Cross-Linking-MS (XL-MS) Homo sapiens
150 PSMB6 5694
Co-fractionation Homo sapiens
151 RPN2 6185
Co-fractionation Homo sapiens
152 SHANK1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
153 CANX 821
Co-fractionation Homo sapiens
154 CEP63  
Two-hybrid Homo sapiens
155 TMPO 7112
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
156 RAB5A 5868
Proximity Label-MS Homo sapiens
157 LMNB1 4001
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
158 RC3H2  
Affinity Capture-MS Homo sapiens
159 ECT2 1894
Affinity Capture-MS Homo sapiens
160 SIRT7  
Affinity Capture-MS Homo sapiens
161 FANCD2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
162 CTNNB1 1499
Proximity Label-MS Homo sapiens
163 CTTN 2017
Affinity Capture-MS Homo sapiens
164 MEX3A  
Affinity Capture-RNA Homo sapiens
165 PXDNL  
Co-fractionation Homo sapiens
166 TJP1 7082
Affinity Capture-MS Homo sapiens
167 SLC25A1 6576
Cross-Linking-MS (XL-MS) Homo sapiens
168 CUL3 8452
Affinity Capture-MS Homo sapiens
169 DES 1674
Co-purification Homo sapiens
170 BTF3 689
Affinity Capture-MS Homo sapiens
171 ERCC4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
172 MYO19  
Affinity Capture-MS Homo sapiens
173 RNF138  
Affinity Capture-MS Homo sapiens
174 STYXL1  
Affinity Capture-MS Homo sapiens
175 SMCHD1 23347
Affinity Capture-MS Homo sapiens
176 TSSC4  
Two-hybrid Homo sapiens
177 RAB35 11021
Proximity Label-MS Homo sapiens
178 MYO1C 4641
Affinity Capture-MS Homo sapiens
179 PLEKHA5 54477
Two-hybrid Homo sapiens
180 CDK2 1017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 FANCA  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
182 MAPK6  
Two-hybrid Homo sapiens
183 SYNPO 11346
Affinity Capture-MS Homo sapiens
184 STAT1 6772
Two-hybrid Homo sapiens
185 VCL 7414
Affinity Capture-MS Homo sapiens
186 MYC  
Affinity Capture-MS Homo sapiens
187 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
188 GRIN2B  
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
189 SAV1  
Affinity Capture-MS Homo sapiens
190 EPB41 2035
Reconstituted Complex Homo sapiens
191 KALRN 8997
Two-hybrid Homo sapiens
192 CLTB 1212
Co-fractionation Homo sapiens
193 SFN 2810
Co-fractionation Homo sapiens
194 CAPZA2 830
Affinity Capture-MS Homo sapiens
195 EBAG9 9166
Proximity Label-MS Homo sapiens
196 MYH7 4625
Affinity Capture-MS Homo sapiens
197 SF3B3 23450
Co-fractionation Homo sapiens
198 VDAC1 7416
Co-fractionation Homo sapiens
199 KIAA0368 23392
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
200 MSN 4478
Affinity Capture-Western Homo sapiens
201 RHOB 388
Proximity Label-MS Homo sapiens
202 DIRAS3  
Proximity Label-MS Homo sapiens
203 Ppp1cb 19046
Affinity Capture-MS Mus musculus
204 PDP1 54704
Affinity Capture-MS Homo sapiens
205 2510003E04Rik  
Affinity Capture-MS Mus musculus
206 ANK3  
Proximity Label-MS Homo sapiens
207 FLOT1 10211
Proximity Label-MS Homo sapiens
208 PIN4 5303
Two-hybrid Homo sapiens
209 EHBP1L1 254102
Co-fractionation Homo sapiens
210 U2SURP 23350
Cross-Linking-MS (XL-MS) Homo sapiens
211 Lima1  
Affinity Capture-MS Mus musculus
212 GRK5 2869
Affinity Capture-MS Homo sapiens
213 SPTBN1 6711
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
214 PDLIM7 9260
Affinity Capture-MS Homo sapiens
215 SNW1 22938
Affinity Capture-MS Homo sapiens
216 ARRB2 409
Affinity Capture-MS Homo sapiens
217 CASP7  
Biochemical Activity Homo sapiens
218 PLS1 5357
Co-fractionation Homo sapiens
219 NEUROG3  
Affinity Capture-MS Homo sapiens
220 Tmod3 50875
Affinity Capture-MS Mus musculus
221 PSMB5 5693
Cross-Linking-MS (XL-MS) Homo sapiens
222 PLEC 5339
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
223 SHANK3 85358
Two-hybrid Homo sapiens
224 WDR77 79084
Affinity Capture-MS Homo sapiens
225 JUP 3728
Affinity Capture-MS Homo sapiens
226 MCAT 27349
Co-fractionation Homo sapiens
227 FANCC 2176
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
228 TOMM22 56993
Co-fractionation Homo sapiens
229 EPB42 2038
Reconstituted Complex Homo sapiens
230 Timeless  
Affinity Capture-MS Mus musculus
231 MCM5 4174
Co-fractionation Homo sapiens
232 EZR 7430
Proximity Label-MS Homo sapiens
233 RPA1 6117
Affinity Capture-MS Homo sapiens
234 Myo1c 17913
Affinity Capture-MS Mus musculus
235 LCK 3932
Proximity Label-MS Homo sapiens
236 STX4 6810
Proximity Label-MS Homo sapiens
237 PTBP1 5725
Co-fractionation Homo sapiens
238 ABL1 25
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
239 MLH1 4292
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
240 CREBBP  
Two-hybrid Homo sapiens
241 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
242 EIF4A3 9775
Affinity Capture-MS Homo sapiens
243 DDX19A 55308
Co-fractionation Homo sapiens
244 HNRNPK 3190
Co-fractionation Homo sapiens
245 TP53 7157
Affinity Capture-MS Homo sapiens
246 Myh10 77579
Affinity Capture-MS Mus musculus
247 ESR1  
Affinity Capture-MS Homo sapiens
248 EEF2 1938
Cross-Linking-MS (XL-MS) Homo sapiens
249 UFL1 23376
Affinity Capture-MS Homo sapiens
250 Samm50  
Affinity Capture-MS Mus musculus
251 TERF1 7013
Affinity Capture-MS Homo sapiens
252 CHMP4C 92421
Affinity Capture-MS Homo sapiens
253 SPTBN2 6712
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
254 RPS24 6229
Co-fractionation Homo sapiens
255 BCL2L1 598
Affinity Capture-MS Homo sapiens
256 ARRB1 408
Affinity Capture-MS Homo sapiens
257 MAPK9 5601
Affinity Capture-MS Homo sapiens
258 FLNA 2316
Affinity Capture-MS Homo sapiens
259 PINK1  
Affinity Capture-MS Homo sapiens
260 RAB11A 8766
Proximity Label-MS Homo sapiens
261 HES1 3280
Affinity Capture-MS Homo sapiens
262 GATA2  
Affinity Capture-MS Homo sapiens
263 Flot1 14251
Affinity Capture-MS Mus musculus
264 ERG  
Affinity Capture-MS Homo sapiens
265 TAF1  
Two-hybrid Homo sapiens
266 CLPTM1L 81037
Co-fractionation Homo sapiens
267 Flnb 286940
Affinity Capture-MS Mus musculus
268 ALB 213
Cross-Linking-MS (XL-MS) Homo sapiens
269 YWHAE 7531
Cross-Linking-MS (XL-MS) Homo sapiens
270 NEFL 4747
Reconstituted Complex Homo sapiens
271 HSPA12A 259217
Proximity Label-MS Homo sapiens
272 VIM 7431
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
273 SAP18 10284
Co-fractionation Homo sapiens
274 PRMT1 3276
Affinity Capture-MS Homo sapiens
275 CAV1 857
Proximity Label-MS Homo sapiens
276 GRIA2  
Far Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
277 Tpx2  
Affinity Capture-MS Mus musculus
278 NEDD8 4738
Affinity Capture-MS Homo sapiens
279 CDC5L 988
Affinity Capture-MS Homo sapiens
280 SPTBN5 51332
Co-fractionation Homo sapiens
281 CAPN2 824
Co-fractionation Homo sapiens
282 DYRK1A 1859
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SPTAN1 is involved
PathwayEvidenceSource
Apoptosis TAS Reactome
Apoptotic cleavage of cellular proteins TAS Reactome
Apoptotic execution phase TAS Reactome
Asparagine N-linked glycosylation TAS Reactome
Axon guidance TAS Reactome
Axon guidance IEA Reactome
Caspase-mediated cleavage of cytoskeletal proteins TAS Reactome
Cell-Cell communication IEA Reactome
COPI-mediated anterograde transport TAS Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
ER to Golgi Anterograde Transport TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Interaction between L1 and Ankyrins TAS Reactome
Interaction between L1 and Ankyrins IEA Reactome
L1CAM interactions TAS Reactome
L1CAM interactions IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Membrane Trafficking TAS Reactome
Metabolism of proteins TAS Reactome
NCAM signaling for neurite out-growth TAS Reactome
NCAM signaling for neurite out-growth IEA Reactome
Nephrin family interactions IEA Reactome
Nervous system development TAS Reactome
Nervous system development IEA Reactome
Neutrophil degranulation TAS Reactome
Post-translational protein modification TAS Reactome
Programmed Cell Death TAS Reactome
RAF/MAP kinase cascade TAS Reactome
RHO GTPase cycle TAS Reactome
RHOU GTPase cycle TAS Reactome
RHOV GTPase cycle TAS Reactome
Sensory Perception IEA Reactome
Sensory processing of sound IEA Reactome
Sensory processing of sound by inner hair cells of the cochlea IEA Reactome
Sensory processing of sound by outer hair cells of the cochlea IEA Reactome
Signal Transduction TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Transport to the Golgi and subsequent modification TAS Reactome
Vesicle-mediated transport TAS Reactome





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