Gene description for CBL
Gene name	Cbl proto-oncogene, E3 ubiquitin protein ligase
Gene symbol	CBL
Other names/aliases	C-CBL CBL2 FRA11B NSLL RNF55
Species	Homo sapiens
Database cross references - CBL
ExoCarta	ExoCarta_867
Entrez Gene	867
HGNC	1541
MIM	165360
UniProt	P22681
CBL identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Neuroblastoma cells	25944692

Gene ontology annotations for CBL

Molecular Function     protein binding GO:0005515 IPI     signal transducer activity GO:0004871 IEA     ubiquitin-protein transferase activity GO:0004842 TAS     ephrin receptor binding GO:0046875 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 TAS     SH3 domain binding GO:0017124 IPI     ligase activity GO:0016874 IEA     calcium ion binding GO:0005509 IEA     phosphotyrosine binding GO:0001784 IEA     zinc ion binding GO:0008270 IEA     ubiquitin protein ligase activity GO:0061630 TAS Biological Process     negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 TAS     negative regulation of apoptotic process GO:0043066 IMP     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     protein ubiquitination GO:0016567 TAS     positive regulation of receptor-mediated endocytosis GO:0048260 TAS     cell surface receptor signaling pathway GO:0007166 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     regulation of transcription, DNA-templated GO:0006355 TAS     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IMP     transforming growth factor beta receptor signaling pathway GO:0007179 TAS Subcellular Localization     flotillin complex GO:0016600 ISS     nucleus GO:0005634 IEA     cytoplasm GO:0005737 IDA     plasma membrane GO:0005886 TAS     cytosol GO:0005829 TAS