Gene description for INPPL1
Gene name inositol polyphosphate phosphatase-like 1
Gene symbol INPPL1
Other names/aliases OPSMD
SHIP2
Species Homo sapiens
 Database cross references - INPPL1
ExoCarta ExoCarta_3636
Entrez Gene 3636
HGNC 6080
MIM 600829
UniProt O15357  
 INPPL1 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for INPPL1
Molecular Function
    actin binding GO:0003779 IEA
    SH3 domain binding GO:0017124 IEA
    hydrolase activity GO:0016787 IEA
    SH2 domain binding GO:0042169 IPI
    protein binding GO:0005515 IPI
Biological Process
    endochondral ossification GO:0001958 IMP
    cell adhesion GO:0007155 TAS
    endocytosis GO:0006897 IMP
    phosphatidylinositol dephosphorylation GO:0046856 IEA
    actin filament organization GO:0007015 IMP
    small molecule metabolic process GO:0044281 TAS
    immune system process GO:0002376 IEA
    response to insulin GO:0032868 IEA
    phospholipid metabolic process GO:0006644 TAS
    negative regulation of cell proliferation GO:0008285 IEA
    inositol phosphate metabolic process GO:0043647 TAS
    ruffle assembly GO:0097178 IEA
    post-embryonic development GO:0009791 IEA
    glucose metabolic process GO:0006006 IEA
    negative regulation of gene expression GO:0010629 IEA
    phosphatidylinositol biosynthetic process GO:0006661 TAS
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    cytoskeleton GO:0005856 IEA
    lamellipodium GO:0030027 IEA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IEA
    cytosol GO:0005829 TAS
    filopodium GO:0030175 IEA
 Experiment description of studies that identified INPPL1 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for INPPL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLNC 2318
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 FCGR2B  
Invivo Homo sapiens
Invitro Homo sapiens
3 CBL 867
Invivo Homo sapiens
4 BCAR1 9564
Invivo Homo sapiens
Invitro Homo sapiens
5 ABL1 25
Affinity Capture-Western Homo sapiens
6 EGFR 1956
Affinity Capture-Western Homo sapiens
7 SHC1 6464
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
8 SORBS1 10580
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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