Gene description for BHMT2
Gene name betaine--homocysteine S-methyltransferase 2
Gene symbol BHMT2
Other names/aliases -
Species Homo sapiens
 Database cross references - BHMT2
ExoCarta ExoCarta_23743
Entrez Gene 23743
HGNC 1048
MIM 605932
UniProt Q9H2M3  
 BHMT2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Urine 19056867    
 Gene ontology annotations for BHMT2
Molecular Function
    zinc ion binding GO:0008270 IDA
    betaine-homocysteine S-methyltransferase activity GO:0047150 IDA
    S-adenosylmethionine-homocysteine S-methyltransferase activity GO:0008898 IDA
    S-methylmethionine-homocysteine S-methyltransferase activity GO:0061627 IDA
Biological Process
    amino-acid betaine metabolic process GO:0006577 IDA
    S-adenosylmethionine metabolic process GO:0046500 IDA
    methylation GO:0032259 IEA
    L-methionine salvage GO:0071267 IDA
    S-methylmethionine cycle GO:0033528 IBA
    S-methylmethionine metabolic process GO:0033477 IDA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytosol GO:0005829 IBA
 Experiment description of studies that identified BHMT2 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BHMT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which BHMT2 is involved
No pathways found





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