Gene description for RRM2B
Gene name ribonucleotide reductase M2 B (TP53 inducible)
Gene symbol RRM2B
Other names/aliases MTDPS8A
MTDPS8B
P53R2
Species Homo sapiens
 Database cross references - RRM2B
ExoCarta ExoCarta_50484
Vesiclepedia VP_50484
Entrez Gene 50484
HGNC 17296
MIM 604712
UniProt Q7LG56  
 RRM2B identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RRM2B
Molecular Function
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0004748 IEA
Biological Process
    renal system process GO:0003014 IEA
    deoxyribonucleoside diphosphate metabolic process GO:0009186 IEA
    deoxyribonucleoside triphosphate metabolic process GO:0009200 IEA
    kidney development GO:0001822 IEA
    oxidation-reduction process GO:0055114 IEA
    response to oxidative stress GO:0006979 IEA
    deoxyribonucleotide biosynthetic process GO:0009263 IEA
    negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 IEA
    DNA repair GO:0006281 IEA
    small molecule metabolic process GO:0044281 TAS
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    nucleobase-containing small molecule interconversion GO:0015949 TAS
    gene expression GO:0010467 TAS
    mitochondrial DNA replication GO:0006264 IEA
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 TAS
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified RRM2B in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RRM2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TP53 7157
Affinity Capture-Western Homo sapiens
2 RRM1 6240
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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