Gene description for MAP3K13
Gene name mitogen-activated protein kinase kinase kinase 13
Gene symbol MAP3K13
Other names/aliases LZK
MEKK13
MLK
Species Homo sapiens
 Database cross references - MAP3K13
ExoCarta ExoCarta_9175
Vesiclepedia VP_9175
Entrez Gene 9175
HGNC 6852
MIM 604915
UniProt O43283  
 MAP3K13 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MAP3K13
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 ISS
    MAP kinase kinase kinase activity GO:0004709 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IPI
    protein kinase binding GO:0019901 ISS
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    protein serine/threonine kinase activator activity GO:0043539 ISS
    metal ion binding GO:0046872 IEA
    IkappaB kinase complex binding GO:0106137 IDA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    protein phosphorylation GO:0006468 IDA
    JNK cascade GO:0007254 IBA
    JNK cascade GO:0007254 IDA
    JNK cascade GO:0007254 ISS
    positive regulation of neuron maturation GO:0014042 ISS
    peptidyl-serine phosphorylation GO:0018105 ISS
    positive regulation of JUN kinase activity GO:0043507 ISS
    positive regulation of axon extension GO:0045773 ISS
    protein autophosphorylation GO:0046777 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    stress-activated MAPK cascade GO:0051403 IDA
    positive regulation of neuron projection arborization GO:0150012 ISS
    positive regulation of branching morphogenesis of a nerve GO:1905492 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    membrane GO:0016020 IDA
 Experiment description of studies that identified MAP3K13 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MAP3K13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP2K7 5609
Biochemical Activity Homo sapiens
2 KLHL20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MAPK8IP1 9479
Affinity Capture-Western Homo sapiens
4 GLO1 2739
Two-hybrid Homo sapiens
5 MYC  
Dosage Lethality Homo sapiens
6 MAP3K13 9175
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 IKBKB 3551
Affinity Capture-Western Homo sapiens
8 PRDX3 10935
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
9 HLA-DRB3 3125
Two-hybrid Homo sapiens
10 STAT3 6774
Two-hybrid Homo sapiens
11 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 INPPL1 3636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SOX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MAP3K13 is involved
No pathways found





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