Gene description for MAP3K13
Gene name mitogen-activated protein kinase kinase kinase 13
Gene symbol MAP3K13
Other names/aliases LZK
MEKK13
MLK
Species Homo sapiens
 Database cross references - MAP3K13
ExoCarta ExoCarta_9175
Entrez Gene 9175
HGNC 6852
MIM 604915
UniProt O43283  
 MAP3K13 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MAP3K13
Molecular Function
    metal ion binding GO:0046872 IEA
    identical protein binding GO:0042802 IPI
    protein kinase binding GO:0019901 ISS
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
    ATP binding GO:0005524 IEA
    protein serine/threonine kinase activity GO:0004674 IDA
    MAP kinase kinase kinase activity GO:0004709 IDA
Biological Process
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    protein autophosphorylation GO:0046777 IDA
    protein phosphorylation GO:0006468 IDA
    activation of MAPKK activity GO:0000186 IDA
    JNK cascade GO:0007254 IDA
Subcellular Localization
    membrane GO:0016020 IDA
    IkappaB kinase complex GO:0008385 IDA
 Experiment description of studies that identified MAP3K13 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MAP3K13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAP3K13 9175
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 IKBKB 3551
Affinity Capture-Western Homo sapiens
3 PRDX3 10935
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 MAPK8IP1 9479
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which MAP3K13 is involved
No pathways found





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