Gene description for HLA-DRB3
Gene name	major histocompatibility complex, class II, DR beta 3
Gene symbol	HLA-DRB3
Other names/aliases	HLA-DR3B
Species	Homo sapiens
Database cross references - HLA-DRB3
ExoCarta	ExoCarta_3125
Vesiclepedia	VP_3125
Entrez Gene	3125
HGNC	4951
MIM	612735
UniProt	P79483
HLA-DRB3 identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for HLA-DRB3

Molecular Function     peptide antigen binding GO:0042605 ISS     MHC class II receptor activity GO:0032395 TAS     protein binding GO:0005515 IPI Biological Process     inflammatory response to antigenic stimulus GO:0002437 IDA     T cell costimulation GO:0031295 TAS     negative regulation of T cell proliferation GO:0042130 IMP     regulation of interleukin-10 secretion GO:2001179 IDA     detection of bacterium GO:0016045 IMP     humoral immune response mediated by circulating immunoglobulin GO:0002455 IDA     positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IMP     T cell receptor signaling pathway GO:0050852 TAS     T-helper 1 type immune response GO:0042088 IMP     regulation of interleukin-4 production GO:0032673 IDA     antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS     interferon-gamma-mediated signaling pathway GO:0060333 TAS     negative regulation of interferon-gamma production GO:0032689 IMP     protein tetramerization GO:0051262 IDA     signal transduction GO:0007165 NAS     immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 IDA     cytokine-mediated signaling pathway GO:0019221 TAS     immune response GO:0006955 TAS Subcellular Localization     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     late endosome membrane GO:0031902 IDA     Golgi membrane GO:0000139 TAS     endocytic vesicle membrane GO:0030666 TAS     trans-Golgi network membrane GO:0032588 TAS     MHC class II protein complex GO:0042613 ISS     integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 TAS     lysosomal membrane GO:0005765 TAS     transport vesicle membrane GO:0030658 TAS     ER to Golgi transport vesicle membrane GO:0012507 TAS     membrane GO:0016020 TAS     integral component of plasma membrane GO:0005887 NAS     plasma membrane GO:0005886 TAS     external side of plasma membrane GO:0009897 IDA