Gene description for IL27RA
Gene name interleukin 27 receptor, alpha
Gene symbol IL27RA
Other names/aliases CRL1
Species Homo sapiens
 Database cross references - IL27RA
ExoCarta ExoCarta_9466
Entrez Gene 9466
HGNC 17290
MIM 605350
UniProt Q6UWB1  
 IL27RA identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for IL27RA
Molecular Function
    interleukin-27 receptor activity GO:0045509 IEA
    transmembrane signaling receptor activity GO:0004888 TAS
Biological Process
    negative regulation of type 2 immune response GO:0002829 IEA
    cell surface receptor signaling pathway GO:0007166 TAS
    positive regulation of T-helper 1 type immune response GO:0002827 IEA
    interleukin-27-mediated signaling pathway GO:0070106 IEA
    positive regulation of interferon-gamma production GO:0032729 IEA
    regulation of isotype switching to IgG isotypes GO:0048302 IEA
    immune response GO:0006955 TAS
    defense response to Gram-positive bacterium GO:0050830 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified IL27RA in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for IL27RA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STAT1 6772
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 EBI3  
Affinity Capture-Western Homo sapiens
3 JAK1 3716
Affinity Capture-Western Homo sapiens
4 GOSR1 9527
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which IL27RA is involved
No pathways found

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