Gene description for TNFSF18
Gene name tumor necrosis factor (ligand) superfamily, member 18
Gene symbol TNFSF18
Other names/aliases AITRL
GITRL
TL6
hGITRL
Species Homo sapiens
 Database cross references - TNFSF18
ExoCarta ExoCarta_8995
Vesiclepedia VP_8995
Entrez Gene 8995
HGNC 11932
MIM 603898
UniProt Q9UNG2  
 TNFSF18 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TNFSF18
Molecular Function
    signaling receptor binding GO:0005102 TAS
    cytokine activity GO:0005125 IEA
    protein binding GO:0005515 IPI
    tumor necrosis factor receptor superfamily binding GO:0032813 IBA
    tumor necrosis factor receptor superfamily binding GO:0032813 ISS
    identical protein binding GO:0042802 IPI
Biological Process
    adaptive immune response GO:0002250 IEA
    T cell proliferation involved in immune response GO:0002309 IBA
    T cell proliferation involved in immune response GO:0002309 ISS
    positive regulation of leukocyte migration GO:0002687 IMP
    signal transduction GO:0007165 TAS
    cell-cell signaling GO:0007267 TAS
    positive regulation of macrophage chemotaxis GO:0010759 IEA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IBA
    tumor necrosis factor-mediated signaling pathway GO:0033209 ISS
    regulation of T cell proliferation GO:0042129 IBA
    regulation of T cell proliferation GO:0042129 ISS
    positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IMP
    negative regulation of apoptotic process GO:0043066 TAS
    regulation of protein-containing complex assembly GO:0043254 IEA
    positive regulation of cell adhesion GO:0045785 IMP
    positive regulation of inflammatory response GO:0050729 IEA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS
    positive regulation of monocyte chemotaxis GO:0090026 IEA
    negative regulation of T-helper 17 cell lineage commitment GO:2000329 IEA
    regulation of dendritic cell chemotaxis GO:2000508 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
    plasma membrane GO:0005886 TAS
    cell surface GO:0009986 IBA
    cell surface GO:0009986 ISS
 Experiment description of studies that identified TNFSF18 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TNFSF18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PEX13  
Affinity Capture-MS Homo sapiens
2 SLC19A2 10560
Affinity Capture-MS Homo sapiens
3 SUN1 23353
Affinity Capture-MS Homo sapiens
4 FAM171A2 284069
Affinity Capture-MS Homo sapiens
5 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
6 GPRC5C 55890
Affinity Capture-MS Homo sapiens
7 ITM2B 9445
Affinity Capture-MS Homo sapiens
8 TMEM30A 55754
Affinity Capture-MS Homo sapiens
9 CXCR4 7852
Affinity Capture-MS Homo sapiens
10 LRFN1  
Affinity Capture-MS Homo sapiens
11 RNF185  
Affinity Capture-MS Homo sapiens
12 ZFYVE27 118813
Affinity Capture-MS Homo sapiens
13 TMEM68  
Affinity Capture-MS Homo sapiens
14 LETMD1  
Affinity Capture-MS Homo sapiens
15 TMEM120A 83862
Affinity Capture-MS Homo sapiens
16 JPH1 56704
Affinity Capture-MS Homo sapiens
17 TMEM120B  
Affinity Capture-MS Homo sapiens
18 POMGNT1 55624
Affinity Capture-MS Homo sapiens
19 LRFN3  
Affinity Capture-MS Homo sapiens
20 RTN2 6253
Affinity Capture-MS Homo sapiens
21 TMEM160 54958
Affinity Capture-MS Homo sapiens
22 SQSTM1 8878
Affinity Capture-MS Homo sapiens
23 FUT8 2530
Affinity Capture-MS Homo sapiens
24 SYNE1 23345
Affinity Capture-MS Homo sapiens
25 TMEM126A 84233
Affinity Capture-MS Homo sapiens
26 PTPN2 5771
Affinity Capture-MS Homo sapiens
27 NRM 11270
Affinity Capture-MS Homo sapiens
28 PODXL2 50512
Affinity Capture-MS Homo sapiens
29 PTPN1 5770
Affinity Capture-MS Homo sapiens
30 S1PR2 9294
Affinity Capture-MS Homo sapiens
31 LPCAT3 10162
Affinity Capture-MS Homo sapiens
32 NAT14 57106
Affinity Capture-MS Homo sapiens
33 SCAP  
Affinity Capture-MS Homo sapiens
34 LPAR1 1902
Affinity Capture-MS Homo sapiens
35 CERS2 29956
Affinity Capture-MS Homo sapiens
36 VANGL2  
Affinity Capture-MS Homo sapiens
37 EXOC3L2  
Two-hybrid Homo sapiens
38 TMEM259 91304
Affinity Capture-MS Homo sapiens
39 ITFG1 81533
Affinity Capture-MS Homo sapiens
40 FAM134C 162427
Affinity Capture-MS Homo sapiens
41 MAN1A2 10905
Affinity Capture-MS Homo sapiens
42 MAN2A2 4122
Affinity Capture-MS Homo sapiens
43 TMEM59L  
Affinity Capture-MS Homo sapiens
44 SCARB1 949
Affinity Capture-MS Homo sapiens
45 NLGN2 57555
Affinity Capture-MS Homo sapiens
46 IL27RA 9466
Affinity Capture-MS Homo sapiens
47 B4GALT7 11285
Affinity Capture-MS Homo sapiens
48 NLGN1  
Affinity Capture-MS Homo sapiens
49 CERS6  
Affinity Capture-MS Homo sapiens
50 CUX1 1523
Affinity Capture-MS Homo sapiens
51 MGAT1 4245
Affinity Capture-MS Homo sapiens
52 VMA21  
Affinity Capture-MS Homo sapiens
53 TMEM56  
Affinity Capture-MS Homo sapiens
54 NTSR1  
Affinity Capture-MS Homo sapiens
55 GOLGA5 9950
Affinity Capture-MS Homo sapiens
56 ABCB10 23456
Affinity Capture-MS Homo sapiens
57 XYLT2 64132
Affinity Capture-MS Homo sapiens
58 TNFSF9  
Affinity Capture-MS Homo sapiens
59 TMEM70  
Affinity Capture-MS Homo sapiens
60 ADGRE5 976
Affinity Capture-MS Homo sapiens
61 C3orf52  
Affinity Capture-MS Homo sapiens
62 SUN2 25777
Affinity Capture-MS Homo sapiens
63 KDSR 2531
Affinity Capture-MS Homo sapiens
64 TSPAN3 10099
Affinity Capture-MS Homo sapiens
65 SLC47A1  
Affinity Capture-MS Homo sapiens
66 TMPPE  
Affinity Capture-MS Homo sapiens
67 YIF1B 90522
Affinity Capture-MS Homo sapiens
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