Gene description for TNFSF18
Gene name tumor necrosis factor (ligand) superfamily, member 18
Gene symbol TNFSF18
Other names/aliases AITRL
GITRL
TL6
hGITRL
Species Homo sapiens
 Database cross references - TNFSF18
ExoCarta ExoCarta_8995
Entrez Gene 8995
HGNC 11932
MIM 603898
UniProt Q9UNG2  
 TNFSF18 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TNFSF18
Molecular Function
    tumor necrosis factor receptor superfamily binding GO:0032813 ISS
    tumor necrosis factor receptor binding GO:0005164 IEA
    cytokine activity GO:0005125 IEA
    receptor binding GO:0005102 TAS
Biological Process
    T cell proliferation involved in immune response GO:0002309 ISS
    positive regulation of leukocyte migration GO:0002687 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS
    positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 IMP
    cell-cell signaling GO:0007267 TAS
    regulation of T cell proliferation GO:0042129 ISS
    signal transduction GO:0007165 TAS
    positive regulation of cell adhesion GO:0045785 IMP
    tumor necrosis factor-mediated signaling pathway GO:0033209 ISS
    negative regulation of apoptotic process GO:0043066 TAS
Subcellular Localization
    plasma membrane GO:0005886 IEA
    cell surface GO:0009986 ISS
    integral component of membrane GO:0016021 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified TNFSF18 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TNFSF18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNFRSF18  
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which TNFSF18 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here