Gene description for B4GALT7
Gene name xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
Gene symbol B4GALT7
Other names/aliases EDSP1
XGALT1
XGPT1
Species Homo sapiens
 Database cross references - B4GALT7
ExoCarta ExoCarta_11285
Vesiclepedia VP_11285
Entrez Gene 11285
HGNC 930
MIM 604327
UniProt Q9UBV7  
 B4GALT7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for B4GALT7
Molecular Function
    beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity GO:0003831 IDA
    protein binding GO:0005515 IPI
    galactosyltransferase activity GO:0008378 IDA
    galactosyltransferase activity GO:0008378 IMP
    manganese ion binding GO:0030145 IDA
    xylosylprotein 4-beta-galactosyltransferase activity GO:0046525 IBA
    xylosylprotein 4-beta-galactosyltransferase activity GO:0046525 IDA
    xylosylprotein 4-beta-galactosyltransferase activity GO:0046525 TAS
Biological Process
    carbohydrate metabolic process GO:0005975 IEA
    glycosaminoglycan biosynthetic process GO:0006024 IDA
    proteoglycan metabolic process GO:0006029 IMP
    protein N-linked glycosylation GO:0006487 IDA
    proteoglycan biosynthetic process GO:0030166 IBA
    glycosaminoglycan metabolic process GO:0030203 TAS
    protein modification process GO:0036211 TAS
    negative regulation of fibroblast proliferation GO:0048147 IMP
    glycosylation GO:0070085 IBA
    supramolecular fiber organization GO:0097435 IMP
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 IDA
    Golgi cisterna membrane GO:0032580 IEA
 Experiment description of studies that identified B4GALT7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for B4GALT7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-7  
Two-hybrid Homo sapiens
2 NRG1 3084
Affinity Capture-MS Homo sapiens
3 CCL3  
Affinity Capture-MS Homo sapiens
4 HFE  
Affinity Capture-MS Homo sapiens
5 Tmed2 56334
Affinity Capture-MS Mus musculus
6 C5AR1  
Affinity Capture-MS Homo sapiens
7 HSPA5 3309
Affinity Capture-MS Homo sapiens
8 TMEM106A  
Affinity Capture-MS Homo sapiens
9 SV2A 9900
Affinity Capture-MS Homo sapiens
10 VNN2  
Affinity Capture-MS Homo sapiens
11 THOC1 9984
Affinity Capture-MS Homo sapiens
12 TMEM59 9528
Affinity Capture-MS Homo sapiens
13 FAM20C 56975
Affinity Capture-MS Homo sapiens
14 KIAA1107  
Affinity Capture-MS Homo sapiens
15 TP53 7157
Negative Genetic Homo sapiens
16 Iffo1  
Affinity Capture-MS Mus musculus
17 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LDLRAD1  
Affinity Capture-MS Homo sapiens
19 SMIM5  
Affinity Capture-MS Homo sapiens
20 NIPAL1  
Affinity Capture-MS Homo sapiens
21 HPN  
Affinity Capture-MS Homo sapiens
22 TNFSF11  
Affinity Capture-MS Homo sapiens
23 EZR 7430
Affinity Capture-MS Homo sapiens
24 SLC39A7 7922
Affinity Capture-MS Homo sapiens
25 ID1  
Affinity Capture-MS Homo sapiens
26 ADPGK 83440
Affinity Capture-MS Homo sapiens
27 YWHAZ 7534
Affinity Capture-MS Homo sapiens
28 ST7  
Affinity Capture-MS Homo sapiens
29 B4GAT1 11041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GBA 2629
Affinity Capture-MS Homo sapiens
31 GAA 2548
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 KRTAP10-3  
Two-hybrid Homo sapiens
33 FUT1  
Affinity Capture-MS Homo sapiens
34 RABGGTB 5876
Two-hybrid Homo sapiens
35 GPRC5D  
Affinity Capture-MS Homo sapiens
36 TNFSF18 8995
Affinity Capture-MS Homo sapiens
37 Cep152  
Affinity Capture-MS Mus musculus
38 PCNA 5111
Affinity Capture-MS Homo sapiens
39 SCN4A  
Affinity Capture-MS Homo sapiens
40 CHRNB2  
Affinity Capture-MS Homo sapiens
41 CDC16 8881
Affinity Capture-MS Homo sapiens
42 MYC  
Affinity Capture-MS Homo sapiens
43 SEC62 7095
Affinity Capture-MS Homo sapiens
44 Chmp3  
Affinity Capture-MS Mus musculus
45 TMPRSS13  
Affinity Capture-MS Homo sapiens
46 SCGB2A2  
Affinity Capture-MS Homo sapiens
47 C1orf54  
Affinity Capture-MS Homo sapiens
48 CRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 GINM1 116254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PRC1 9055
Affinity Capture-MS Homo sapiens
51 ADGRE5 976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 YIPF3 25844
Affinity Capture-MS Homo sapiens
53 KLRC1  
Affinity Capture-MS Homo sapiens
54 ST14 6768
Affinity Capture-MS Homo sapiens
55 TSPAN31 6302
Affinity Capture-MS Homo sapiens
56 UPK1A 11045
Affinity Capture-MS Homo sapiens
57 SLC22A4 6583
Affinity Capture-MS Homo sapiens
58 PTCH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 CHRNA4  
Affinity Capture-MS Homo sapiens
60 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 TTYH1  
Affinity Capture-MS Homo sapiens
62 C10orf2 56652
Affinity Capture-MS Homo sapiens
63 TMEM192 201931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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