Gene description for SLC39A7
Gene name solute carrier family 39 (zinc transporter), member 7
Gene symbol SLC39A7
Other names/aliases D6S115E
D6S2244E
H2-KE4
HKE4
KE4
RING5
ZIP7
Species Homo sapiens
 Database cross references - SLC39A7
ExoCarta ExoCarta_7922
Vesiclepedia VP_7922
Entrez Gene 7922
HGNC 4927
MIM 601416
UniProt Q92504  
 SLC39A7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SLC39A7
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 IDA
    zinc ion transmembrane transporter activity GO:0005385 IMP
    zinc ion transmembrane transporter activity GO:0005385 TAS
    protein binding GO:0005515 IPI
Biological Process
    intracellular zinc ion homeostasis GO:0006882 IBA
    intracellular zinc ion homeostasis GO:0006882 IMP
    B cell differentiation GO:0030183 IMP
    zinc ion transmembrane transport GO:0071577 IBA
    zinc ion transmembrane transport GO:0071577 IDA
    zinc ion transmembrane transport GO:0071577 TAS
    skin epidermis development GO:0098773 IEA
    regulation of ferroptosis GO:0110075 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    Golgi apparatus GO:0005794 IEA
    membrane GO:0016020 TAS
 Experiment description of studies that identified SLC39A7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SLC39A7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 LCE1F  
Two-hybrid Homo sapiens
3 MCM3 4172
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 Tmed2 56334
Affinity Capture-MS Mus musculus
6 KIF23 9493
Affinity Capture-MS Homo sapiens
7 LELP1  
Two-hybrid Homo sapiens
8 LCE2C  
Two-hybrid Homo sapiens
9 ZNF703  
Affinity Capture-MS Homo sapiens
10 ARL15 54622
Affinity Capture-MS Homo sapiens
11 PTPN9 5780
Affinity Capture-MS Homo sapiens
12 ROCK2 9475
Affinity Capture-MS Homo sapiens
13 B3GALT4  
Affinity Capture-MS Homo sapiens
14 FAM20B 9917
Affinity Capture-MS Homo sapiens
15 HMMR  
Affinity Capture-MS Homo sapiens
16 APEX1 328
Affinity Capture-RNA Homo sapiens
17 Kcnk1  
Affinity Capture-MS Mus musculus
18 Eef1a1 13627
Affinity Capture-MS Mus musculus
19 TGFB1 7040
Affinity Capture-MS Homo sapiens
20 SMCP  
Two-hybrid Homo sapiens
21 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
22 FAM174A 345757
Affinity Capture-MS Homo sapiens
23 B4GALT7 11285
Affinity Capture-MS Homo sapiens
24 RGS20 8601
Affinity Capture-MS Homo sapiens
25 IGFL3  
Affinity Capture-MS Homo sapiens
26 LCLAT1 253558
Affinity Capture-MS Homo sapiens
27 MAD2L1 4085
Affinity Capture-MS Homo sapiens
28 CTAGE5 4253
Affinity Capture-MS Homo sapiens
29 KIF14 9928
Affinity Capture-MS Homo sapiens
30 TOLLIP 54472
Proximity Label-MS Homo sapiens
31 CD70 970
Affinity Capture-MS Homo sapiens
32 TMEM14B  
Two-hybrid Homo sapiens
33 BACH1 571
Affinity Capture-MS Homo sapiens
34 C12orf49  
Affinity Capture-MS Homo sapiens
35 ESRRB  
Affinity Capture-MS Homo sapiens
36 STXBP1 6812
Affinity Capture-MS Homo sapiens
37 UNC93A  
Two-hybrid Homo sapiens
38 MIA3 375056
Affinity Capture-MS Homo sapiens
39 PKN1 5585
Affinity Capture-MS Homo sapiens
40 RPN1 6184
Proximity Label-MS Homo sapiens
41 AIP 9049
Affinity Capture-MS Homo sapiens
42 SP100 6672
Affinity Capture-MS Homo sapiens
43 MAP2K7 5609
Affinity Capture-MS Homo sapiens
44 CD40 958
Affinity Capture-MS Homo sapiens
45 GJA8  
Two-hybrid Homo sapiens
46 LCE5A  
Two-hybrid Homo sapiens
47 NUDT9 53343
Affinity Capture-MS Homo sapiens
48 KRTAP1-3  
Two-hybrid Homo sapiens
49 TRIM31  
Affinity Capture-MS Homo sapiens
50 CHST8 64377
Affinity Capture-MS Homo sapiens
51 BCAP31 10134
Proximity Label-MS Homo sapiens
52 SLC34A2 10568
Two-hybrid Homo sapiens
53 MBOAT1  
Affinity Capture-MS Homo sapiens
54 LTBP4 8425
Affinity Capture-MS Homo sapiens
55 EGFR 1956
Affinity Capture-MS Homo sapiens
56 YY1 7528
Two-hybrid Homo sapiens
57 ZNF507  
Affinity Capture-MS Homo sapiens
58 LCE2D  
Two-hybrid Homo sapiens
59 KCNF1  
Two-hybrid Homo sapiens
60 SUZ12  
Affinity Capture-MS Homo sapiens
61 SASS6 163786
Affinity Capture-MS Homo sapiens
62 RSPO2  
Two-hybrid Homo sapiens
63 SEMG1 6406
Affinity Capture-MS Homo sapiens
64 PTPRN  
Affinity Capture-MS Homo sapiens
65 GXYLT1 283464
Affinity Capture-MS Homo sapiens
66 KRTAP9-2  
Two-hybrid Homo sapiens
67 LCE4A  
Two-hybrid Homo sapiens
68 BMI1  
Affinity Capture-MS Homo sapiens
69 Cul4a  
Affinity Capture-MS Mus musculus
70 AKAP1 8165
Proximity Label-MS Homo sapiens
71 LCE1C  
Two-hybrid Homo sapiens
72 FBN1 2200
Affinity Capture-MS Homo sapiens
73 GRN 2896
Affinity Capture-MS Homo sapiens
74 LCE1A  
Two-hybrid Homo sapiens
75 USP49 25862
Affinity Capture-MS Homo sapiens
76 Atp7a  
Affinity Capture-MS Mus musculus
77 DSCC1  
Affinity Capture-MS Homo sapiens
78 RGS19 10287
Affinity Capture-MS Homo sapiens
79 TPTE  
Affinity Capture-MS Homo sapiens
80 TNFRSF10D 8793
Two-hybrid Homo sapiens
81 KRTAP5-7  
Two-hybrid Homo sapiens
82 SPRY3  
Two-hybrid Homo sapiens
83 STXBP2 6813
Affinity Capture-MS Homo sapiens
84 DNM3 26052
Affinity Capture-MS Homo sapiens
85 KIAA1644  
Two-hybrid Homo sapiens
86 BRD1 23774
Affinity Capture-MS Homo sapiens
87 LDLR 3949
Affinity Capture-MS Homo sapiens
88 RAB5C 5878
Proximity Label-MS Homo sapiens
89 KCTD18  
Affinity Capture-MS Homo sapiens
90 CRCT1  
Two-hybrid Homo sapiens
91 WFDC12  
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here