Gene description for RGS20
Gene name regulator of G-protein signaling 20
Gene symbol RGS20
Other names/aliases RGSZ1
ZGAP1
g(z)GAP
gz-GAP
Species Homo sapiens
 Database cross references - RGS20
ExoCarta ExoCarta_8601
Entrez Gene 8601
HGNC 14600
MIM 607193
UniProt O76081  
 RGS20 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for RGS20
Molecular Function
    protein binding GO:0005515 IPI
    GTPase activator activity GO:0005096 TAS
Biological Process
    positive regulation of GTPase activity GO:0043547 TAS
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 TAS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IMP
    trans-Golgi network GO:0005802 IMP
 Experiment description of studies that identified RGS20 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RGS20
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 OSTM1  
Two-hybrid Homo sapiens
2 TXLNA 200081
Affinity Capture-MS Homo sapiens
3 GLRX3 10539
Affinity Capture-MS Homo sapiens
4 GNAZ 2781
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
5 SLC39A7  
Affinity Capture-MS Homo sapiens
6 SPTLC1 10558
Affinity Capture-MS Homo sapiens
7 ETEA  
Affinity Capture-MS Homo sapiens
8 MLF2 8079
Affinity Capture-MS Homo sapiens
9 PMVK 10654
Affinity Capture-MS Homo sapiens
10 NSF 4905
Affinity Capture-MS Homo sapiens
11 SET 6418
Affinity Capture-MS Homo sapiens
12 STMN2  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
13 TRMT112 51504
Affinity Capture-MS Homo sapiens
14 BOLA1  
Affinity Capture-MS Homo sapiens
15 RUVBL2 10856
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RGS20 is involved
PathwayEvidenceSource
G alpha (i) signalling events TAS Reactome
G alpha (z) signalling events TAS Reactome





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