Gene description for RGS20
Gene name regulator of G-protein signaling 20
Gene symbol RGS20
Other names/aliases RGSZ1
ZGAP1
g(z)GAP
gz-GAP
Species Homo sapiens
 Database cross references - RGS20
ExoCarta ExoCarta_8601
Vesiclepedia VP_8601
Entrez Gene 8601
HGNC 14600
MIM 607193
UniProt O76081  
 RGS20 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for RGS20
Molecular Function
    GTPase activity GO:0003924 TAS
    GTPase activator activity GO:0005096 TAS
    protein binding GO:0005515 IPI
Biological Process
    response to amphetamine GO:0001975 IEA
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    regulation of G protein-coupled receptor signaling pathway GO:0008277 TAS
    negative regulation of signal transduction GO:0009968 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IMP
    trans-Golgi network GO:0005802 IMP
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified RGS20 in exosomes
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RGS20
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRIM2 5558
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LCE1F  
Two-hybrid Homo sapiens
3 LCE2A  
Two-hybrid Homo sapiens
4 LCE1B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 LCE2C  
Two-hybrid Homo sapiens
6 EFR3A 23167
Affinity Capture-MS Homo sapiens
7 ADRB2  
PCA Homo sapiens
8 TBC1D16  
Two-hybrid Homo sapiens
9 SPTLC1 10558
Affinity Capture-MS Homo sapiens
10 MAPKBP1  
Two-hybrid Homo sapiens
11 KRTAP5-9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 PI4KA 5297
Affinity Capture-MS Homo sapiens
13 FAM126A 84668
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TRMT1L 81627
Affinity Capture-MS Homo sapiens
15 LCE3C  
Two-hybrid Homo sapiens
16 CIAPIN1 57019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 GNAO1 2775
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
18 PTPMT1 114971
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
19 COL8A1 1295
Two-hybrid Homo sapiens
20 NARF 26502
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 KRTAP4-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 CATSPER1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 ABHD17A 81926
Two-hybrid Homo sapiens
24 GNAZ 2781
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
25 RAD50 10111
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 FAF2 23197
Affinity Capture-MS Homo sapiens
27 KIF3A 11127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 DPH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 LCE1A  
Two-hybrid Homo sapiens
30 LCE3A  
Two-hybrid Homo sapiens
31 KRTAP5-6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 AQP1 358
Two-hybrid Homo sapiens
33 FASLG 356
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 HRG 3273
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
35 ZNF444  
Affinity Capture-MS Homo sapiens
36 CRY1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 MRE11A 4361
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CTU2 348180
Affinity Capture-MS Homo sapiens
39 NARFL 64428
Affinity Capture-MS Homo sapiens
40 NBN 4683
Affinity Capture-MS Homo sapiens
41 EFR3B  
Affinity Capture-MS Homo sapiens
42 TXLNG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 LCE3E  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 DCAF10  
Affinity Capture-MS Homo sapiens
46 GNAI2 2771
Two-hybrid Homo sapiens
47 CUL2 8453
Affinity Capture-MS Homo sapiens
48 MLF2 8079
Affinity Capture-MS Homo sapiens
49 ZYG11B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TTC7B 145567
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 KIF3B 9371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 DPH2 1802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 KRTAP9-8  
Two-hybrid Homo sapiens
54 LCE5A  
Two-hybrid Homo sapiens
55 ZNF664  
Affinity Capture-MS Homo sapiens
56 TARBP1 6894
Affinity Capture-MS Homo sapiens
57 STMN2  
Reconstituted Complex Homo sapiens
58 LCE3D  
Two-hybrid Homo sapiens
59 KLHL38  
Two-hybrid Homo sapiens
60 KRTAP9-3  
Two-hybrid Homo sapiens
61 BOLA1 51027
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 HOXA1 3198
Two-hybrid Homo sapiens
63 OTX1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
64 INS 3630
Two-hybrid Homo sapiens
65 Hoxa1  
Two-hybrid Mus musculus
Affinity Capture-Western Mus musculus
66 JUN 3725
Affinity Capture-MS Homo sapiens
67 KRTAP5-11  
Two-hybrid Homo sapiens
68 SET 6418
Affinity Capture-MS Homo sapiens
69 NEK8  
Two-hybrid Homo sapiens
70 LCE2D  
Two-hybrid Homo sapiens
71 LCE4A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
72 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
73 HSPD1 3329
Two-hybrid Homo sapiens
74 ZNF696  
Affinity Capture-MS Homo sapiens
75 TXLNA 200081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 DPP3 10072
Affinity Capture-MS Homo sapiens
77 KIF1A 547
Two-hybrid Homo sapiens
78 PVRL2 5819
Two-hybrid Homo sapiens
79 HID1 283987
Affinity Capture-MS Homo sapiens
80 NSF 4905
Affinity Capture-MS Homo sapiens
81 IREB2 3658
Affinity Capture-MS Homo sapiens
82 MOCOS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 RUVBL2 10856
Affinity Capture-MS Homo sapiens
84 RGS19 10287
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 PGP 283871
Affinity Capture-MS Homo sapiens
86 OSTM1 28962
Two-hybrid Homo sapiens
87 NUFIP2 57532
Two-hybrid Homo sapiens
88 UBA52 7311
Affinity Capture-MS Homo sapiens
89 TYW1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TRMT112 51504
Affinity Capture-MS Homo sapiens
91 PTGER3  
Two-hybrid Homo sapiens
92 AARSD1 80755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 CREB5 9586
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 SELO 83642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 LCE2B  
Two-hybrid Homo sapiens
96 NLN 57486
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 MIOS 54468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 PMVK 10654
Affinity Capture-MS Homo sapiens
99 IFT43  
Affinity Capture-MS Homo sapiens
100 ALPP 250
Two-hybrid Homo sapiens
101 GLRX3 10539
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 SLC39A7 7922
Affinity Capture-MS Homo sapiens
103 VASN 114990
Two-hybrid Homo sapiens
104 PVRL3 25945
Two-hybrid Homo sapiens
105 CRCT1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
106 GFER  
Affinity Capture-MS Homo sapiens
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