Gene description for TRMT1L
Gene name tRNA methyltransferase 1 homolog (S. cerevisiae)-like
Gene symbol TRMT1L
Other names/aliases C1orf25
MST070
MSTP070
TRM1L
bG120K12.3
Species Homo sapiens
 Database cross references - TRMT1L
ExoCarta ExoCarta_81627
Vesiclepedia VP_81627
Entrez Gene 81627
HGNC 16782
MIM 611673
UniProt Q7Z2T5  
 TRMT1L identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Thymus 23844026    
 Gene ontology annotations for TRMT1L
Molecular Function
    tRNA binding GO:0000049 IEA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    tRNA (guanine) methyltransferase activity GO:0016423 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    tRNA N2-guanine methylation GO:0002940 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified TRMT1L in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRMT1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 RPL26L1 51121
Affinity Capture-MS Homo sapiens
3 CD3EAP  
Proximity Label-MS Homo sapiens
4 TARDBP 23435
Affinity Capture-MS Homo sapiens
5 RPL13A 23521
Affinity Capture-MS Homo sapiens
6 RPL10 6134
Affinity Capture-MS Homo sapiens
7 RPL15 6138
Affinity Capture-MS Homo sapiens
8 CAND1 55832
Affinity Capture-MS Homo sapiens
9 SOX2  
Affinity Capture-MS Homo sapiens
10 APP 351
Reconstituted Complex Homo sapiens
11 USP36  
Affinity Capture-MS Homo sapiens
12 RPL4 6124
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HEATR3 55027
Affinity Capture-MS Homo sapiens
14 CFAP97  
Affinity Capture-MS Homo sapiens
15 COPS5 10987
Affinity Capture-MS Homo sapiens
16 NPM1 4869
Affinity Capture-MS Homo sapiens
17 ANOS1 3730
Affinity Capture-MS Homo sapiens
18 H2AFY2 55506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 OBSL1 23363
Affinity Capture-MS Homo sapiens
20 THTPA  
Co-fractionation Homo sapiens
21 ZSCAN31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CRCP  
Affinity Capture-MS Homo sapiens
23 RGS20 8601
Affinity Capture-MS Homo sapiens
24 SRP68 6730
Affinity Capture-MS Homo sapiens
25 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 MAPK14 1432
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PKN2 5586
Affinity Capture-MS Homo sapiens
28 PSPC1 55269
Affinity Capture-MS Homo sapiens
29 RBM42  
Affinity Capture-MS Homo sapiens
30 FEM1A  
Affinity Capture-MS Homo sapiens
31 RPL19 6143
Affinity Capture-MS Homo sapiens
32 RBM8A 9939
Affinity Capture-MS Homo sapiens
33 POLR2K  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 GTF2I 2969
Co-fractionation Homo sapiens
35 PRPF6 24148
Two-hybrid Homo sapiens
36 S100A2 6273
Affinity Capture-MS Homo sapiens
37 DDX21 9188
Affinity Capture-MS Homo sapiens
38 POLR3K  
Affinity Capture-MS Homo sapiens
39 PLEKHO1 51177
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 DRG1 4733
Affinity Capture-MS Homo sapiens
41 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
42 SRSF6 6431
Affinity Capture-MS Homo sapiens
43 POLR3F  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 VRK1 7443
Co-fractionation Homo sapiens
45 RPL5 6125
Affinity Capture-MS Homo sapiens
46 RPL18A 6142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 Srp72  
Affinity Capture-MS Mus musculus
48 BARD1 580
Affinity Capture-MS Homo sapiens
49 NTRK1 4914
Affinity Capture-MS Homo sapiens
50 RPL31 6160
Proximity Label-MS Homo sapiens
51 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CBX6  
Affinity Capture-MS Homo sapiens
53 RPL27A 6157
Affinity Capture-MS Homo sapiens
54 APBA1  
Affinity Capture-MS Homo sapiens
55 HECTD1 25831
Affinity Capture-MS Homo sapiens
56 Ube2i  
Two-hybrid Mus musculus
57 MAGEB2 4113
Affinity Capture-MS Homo sapiens
58 POLR3GL  
Affinity Capture-MS Homo sapiens
59 KDF1  
Affinity Capture-MS Homo sapiens
60 FGFBP1 9982
Affinity Capture-MS Homo sapiens
61 RBM39 9584
Affinity Capture-MS Homo sapiens
62 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 ABT1 29777
Affinity Capture-MS Homo sapiens
64 POLR3A 11128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 POLR2H 5437
Affinity Capture-MS Homo sapiens
66 RC3H2  
Affinity Capture-MS Homo sapiens
67 POLR2E 5434
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CD6 923
Affinity Capture-MS Homo sapiens
69 CUL3 8452
Affinity Capture-MS Homo sapiens
70 Rrbp1  
Affinity Capture-MS Mus musculus
71 RPL3 6122
Affinity Capture-MS Homo sapiens
72 EGFR 1956
Affinity Capture-MS Homo sapiens
73 POLR3E 55718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 SOX15  
Proximity Label-MS Homo sapiens
75 FOXM1  
Affinity Capture-MS Homo sapiens
76 RPL36 25873
Affinity Capture-MS Homo sapiens
77 PCBP1 5093
Affinity Capture-MS Homo sapiens
78 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 RPA3 6119
Proximity Label-MS Homo sapiens
80 RPS13 6207
Affinity Capture-MS Homo sapiens
81 ZNF692  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
83 DDRGK1 65992
Affinity Capture-MS Homo sapiens
84 H2AFB2  
Affinity Capture-MS Homo sapiens
85 HSPD1 3329
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 NOG 9241
Affinity Capture-MS Homo sapiens
87 CCDC140  
Affinity Capture-MS Homo sapiens
88 LMNA 4000
Proximity Label-MS Homo sapiens
89 CBWD1 55871
Affinity Capture-MS Homo sapiens
90 GNB2L1 10399
Affinity Capture-MS Homo sapiens
91 RPL11 6135
Affinity Capture-MS Homo sapiens
92 RPS16 6217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 EIF1AD 84285
Affinity Capture-MS Homo sapiens
94 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
95 PPP4C 5531
Affinity Capture-MS Homo sapiens
96 POLR2F  
Affinity Capture-MS Homo sapiens
97 SIRT6  
Affinity Capture-MS Homo sapiens
98 PARP1 142
Proximity Label-MS Homo sapiens
99 ILF3 3609
Affinity Capture-MS Homo sapiens
100 FBXL6  
Affinity Capture-MS Homo sapiens
101 MNDA 4332
Affinity Capture-MS Homo sapiens
102 POLR3C 10623
Affinity Capture-MS Homo sapiens
103 POLR1C 9533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 TCEA1 6917
Co-fractionation Homo sapiens
105 POLR3H  
Affinity Capture-MS Homo sapiens
106 MEN1 4221
Affinity Capture-MS Homo sapiens
107 SRP19 6728
Affinity Capture-MS Homo sapiens
108 DCTN2 10540
Affinity Capture-MS Homo sapiens
109 SRP72 6731
Affinity Capture-MS Homo sapiens
110 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
111 G3BP2 9908
Affinity Capture-MS Homo sapiens
112 MAGEA9  
Affinity Capture-MS Homo sapiens
113 NIFK 84365
Proximity Label-MS Homo sapiens
114 HNRNPK 3190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 ESR1  
Affinity Capture-MS Homo sapiens
116 UFL1 23376
Affinity Capture-MS Homo sapiens
117 DGKZ  
Affinity Capture-MS Homo sapiens
118 PARK2  
Affinity Capture-MS Homo sapiens
119 POLR3D  
Affinity Capture-MS Homo sapiens
120 CIT 11113
Affinity Capture-MS Homo sapiens
121 POLR3B 55703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 RPL28 6158
Affinity Capture-MS Homo sapiens
123 RPL23A 6147
Affinity Capture-MS Homo sapiens
124 HNRNPU 3192
Affinity Capture-MS Homo sapiens
125 POLR1D 51082
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 RC3H1 149041
Affinity Capture-MS Homo sapiens
127 NTPCR 84284
Co-fractionation Homo sapiens
128 ZNF467  
Affinity Capture-MS Homo sapiens
129 EP300 2033
Affinity Capture-MS Homo sapiens
130 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TRMT1L is involved
No pathways found





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