Gene description for TCEA1
Gene name transcription elongation factor A (SII), 1
Gene symbol TCEA1
Other names/aliases GTF2S
SII
TCEA
TF2S
TFIIS
Species Homo sapiens
 Database cross references - TCEA1
ExoCarta ExoCarta_6917
Entrez Gene 6917
HGNC 11612
MIM 601425
UniProt P23193  
 TCEA1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for TCEA1
Molecular Function
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    erythrocyte differentiation GO:0030218 IEA
    viral process GO:0016032 TAS
    regulation of DNA-templated transcription, elongation GO:0032784 IEA
    positive regulation of viral transcription GO:0050434 TAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    transcription-coupled nucleotide-excision repair GO:0006283 TAS
    transcription elongation from RNA polymerase II promoter GO:0006368 TAS
    nucleotide-excision repair GO:0006289 TAS
    DNA repair GO:0006281 TAS
    gene expression GO:0010467 TAS
Subcellular Localization
    nucleolus GO:0005730 IDA
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified TCEA1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TCEA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2H1 2965
Reconstituted Complex Homo sapiens
2 CTDP1  
Reconstituted Complex Homo sapiens
3 POLR2A 5430
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
4 TCEB3BP1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 GTF2E1  
Invitro Homo sapiens
View the network image/svg+xml



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