Gene description for CTDP1
Gene name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Gene symbol CTDP1
Other names/aliases CCFDN
FCP1
Species Homo sapiens
 Database cross references - CTDP1
ExoCarta ExoCarta_9150
Vesiclepedia VP_9150
Entrez Gene 9150
HGNC 2498
MIM 604927
UniProt Q9Y5B0  
 CTDP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CTDP1
Molecular Function
    TFIIF-class transcription factor complex binding GO:0001096 IPI
    phosphoprotein phosphatase activity GO:0004721 TAS
    protein binding GO:0005515 IPI
    RNA polymerase II CTD heptapeptide repeat phosphatase activity GO:0008420 IBA
    RNA polymerase II CTD heptapeptide repeat phosphatase activity GO:0008420 IDA
    myosin phosphatase activity GO:0017018 IEA
    Tat protein binding GO:0030957 IPI
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    transcription elongation by RNA polymerase II GO:0006368 TAS
    protein dephosphorylation GO:0006470 IDA
    exit from mitosis GO:0010458 IMP
    positive regulation by host of viral transcription GO:0043923 IDA
    cell division GO:0051301 IEA
    negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 IEA
Subcellular Localization
    spindle pole GO:0000922 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IDA
    spindle GO:0005819 IDA
    midbody GO:0030496 IDA
    protein-containing complex GO:0032991 IMP
    intracellular membrane-bounded organelle GO:0043231 IDA
    spindle midzone GO:0051233 IDA
 Experiment description of studies that identified CTDP1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CTDP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
2 DSN1 79980
Affinity Capture-MS Homo sapiens
3 POLR2G 5436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 COPG2 26958
Affinity Capture-MS Homo sapiens
5 GTF2F1 2962
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
6 NUF2  
Affinity Capture-MS Homo sapiens
7 RNGTT 8732
Affinity Capture-MS Homo sapiens
8 UBE4B 10277
Affinity Capture-MS Homo sapiens
9 MED17  
Reconstituted Complex Homo sapiens
10 ADCK3  
Affinity Capture-MS Homo sapiens
11 AKAP13 11214
Affinity Capture-MS Homo sapiens
12 TRRAP 8295
Affinity Capture-MS Homo sapiens
13 PAWR 5074
Affinity Capture-MS Homo sapiens
14 AKAP12 9590
Affinity Capture-MS Homo sapiens
15 CDIPT 10423
Affinity Capture-MS Homo sapiens
16 RFC4 5984
Affinity Capture-MS Homo sapiens
17 TSC2 7249
Affinity Capture-MS Homo sapiens
18 Gtf2b  
Affinity Capture-MS Mus musculus
19 SHROOM2 357
Affinity Capture-MS Homo sapiens
20 EPB41L5 57669
Affinity Capture-MS Homo sapiens
21 MED9  
Affinity Capture-MS Homo sapiens
22 SPTLC1 10558
Affinity Capture-MS Homo sapiens
23 PTPN9 5780
Affinity Capture-MS Homo sapiens
24 KIF20A 10112
Affinity Capture-MS Homo sapiens
25 ATM 472
Affinity Capture-MS Homo sapiens
26 INTS1 26173
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
27 FHOD1 29109
Affinity Capture-MS Homo sapiens
28 LTN1 26046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 MSH3 4437
Affinity Capture-MS Homo sapiens
30 PRKDC 5591
Biochemical Activity Homo sapiens
Protein-peptide Homo sapiens
31 LPCAT1 79888
Affinity Capture-MS Homo sapiens
32 AMOTL1 154810
Affinity Capture-MS Homo sapiens
33 HMMR  
Affinity Capture-MS Homo sapiens
34 APEX1 328
Affinity Capture-RNA Homo sapiens
35 TELO2 9894
Affinity Capture-MS Homo sapiens
36 INTS8  
Reconstituted Complex Homo sapiens
37 DIAPH1 1729
Affinity Capture-MS Homo sapiens
38 RFC3 5983
Affinity Capture-MS Homo sapiens
39 GTF2F2 2963
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
40 HELZ 9931
Affinity Capture-MS Homo sapiens
41 CHP1 11261
Affinity Capture-MS Homo sapiens
42 HLA-B 3106
Affinity Capture-MS Homo sapiens
43 DIAPH2  
Affinity Capture-MS Homo sapiens
44 POLR2I 5438
Affinity Capture-MS Homo sapiens
45 PPP1R18 170954
Affinity Capture-MS Homo sapiens
46 FBXW7  
Synthetic Lethality Homo sapiens
47 PRC1 9055
Affinity Capture-MS Homo sapiens
48 PNPLA6 10908
Affinity Capture-MS Homo sapiens
49 SYT2  
Affinity Capture-MS Homo sapiens
50 MAGED2 10916
Affinity Capture-MS Homo sapiens
51 SFXN4  
Affinity Capture-MS Homo sapiens
52 ERAL1  
Affinity Capture-MS Homo sapiens
53 INTS6 26512
Reconstituted Complex Homo sapiens
54 POLR2C 5432
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
55 BTAF1 9044
Affinity Capture-MS Homo sapiens
56 ACSL1 2180
Affinity Capture-MS Homo sapiens
57 POLR2M  
Affinity Capture-MS Homo sapiens
58 ESYT2 57488
Affinity Capture-MS Homo sapiens
59 AMOT  
Affinity Capture-MS Homo sapiens
60 KIF14 9928
Affinity Capture-MS Homo sapiens
61 MED4 29079
Reconstituted Complex Homo sapiens
62 SAMHD1 25939
Affinity Capture-MS Homo sapiens
63 POLR2K  
Affinity Capture-MS Homo sapiens
64 MED1 5469
Reconstituted Complex Homo sapiens
65 CHMP4C 92421
Affinity Capture-MS Homo sapiens
66 PHLDB2 90102
Affinity Capture-MS Homo sapiens
67 P4HA1 5033
Affinity Capture-MS Homo sapiens
68 MCM3AP  
Affinity Capture-MS Homo sapiens
69 MED7  
Reconstituted Complex Homo sapiens
70 KIAA1211  
Affinity Capture-MS Homo sapiens
71 RFC5 5985
Affinity Capture-MS Homo sapiens
72 COPG1 22820
Affinity Capture-MS Homo sapiens
73 HTT 3064
Affinity Capture-MS Homo sapiens
74 RNF213 57674
Affinity Capture-MS Homo sapiens
75 IWS1  
Affinity Capture-MS Homo sapiens
76 CHMP4B 128866
Affinity Capture-MS Homo sapiens
77 UBR5 51366
Affinity Capture-MS Homo sapiens
78 MED26  
Reconstituted Complex Homo sapiens
79 OPA1 4976
Affinity Capture-MS Homo sapiens
80 XPOT 11260
Affinity Capture-MS Homo sapiens
81 KIAA1522 57648
Affinity Capture-MS Homo sapiens
82 KIAA0391  
Affinity Capture-MS Homo sapiens
83 NCAPD3 23310
Affinity Capture-MS Homo sapiens
84 MED25  
Reconstituted Complex Homo sapiens
85 MED31  
Affinity Capture-MS Homo sapiens
86 MICAL3 57553
Affinity Capture-MS Homo sapiens
87 ENAH 55740
Affinity Capture-MS Homo sapiens
88 UBXN6 80700
Affinity Capture-MS Homo sapiens
89 ABCB7 22
Affinity Capture-MS Homo sapiens
90 POLR2B 5431
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
91 HEATR6  
Affinity Capture-MS Homo sapiens
92 ANLN 54443
Affinity Capture-MS Homo sapiens
93 TRIP13 9319
Affinity Capture-MS Homo sapiens
94 CDK7 1022
Biochemical Activity Homo sapiens
95 TARBP1 6894
Affinity Capture-MS Homo sapiens
96 POLR2H 5437
Affinity Capture-MS Homo sapiens
97 KIAA1244  
Affinity Capture-MS Homo sapiens
98 NUBP2 10101
Affinity Capture-MS Homo sapiens
99 ECT2 1894
Affinity Capture-MS Homo sapiens
100 FGF12  
Affinity Capture-MS Homo sapiens
101 SLC25A22  
Affinity Capture-MS Homo sapiens
102 POLR2E 5434
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
103 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
104 INTS7  
Reconstituted Complex Homo sapiens
105 ELP3 55140
Reconstituted Complex Homo sapiens
106 RICTOR 253260
Affinity Capture-MS Homo sapiens
107 EGFR 1956
Negative Genetic Homo sapiens
108 POLR2D  
Affinity Capture-MS Homo sapiens
109 GBF1 8729
Affinity Capture-MS Homo sapiens
110 METTL21B  
Affinity Capture-MS Homo sapiens
111 UACA 55075
Affinity Capture-MS Homo sapiens
112 POLR2A 5430
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
113 ELP2 55250
Reconstituted Complex Homo sapiens
114 FBXL12 54850
Affinity Capture-MS Homo sapiens
115 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
116 AURKB 9212
Affinity Capture-MS Homo sapiens
117 PRMT5 10419
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
118 ARMC6 93436
Affinity Capture-MS Homo sapiens
119 MED24 9862
Reconstituted Complex Homo sapiens
120 RPA3 6119
Proximity Label-MS Homo sapiens
121 SF3B6 51639
Affinity Capture-MS Homo sapiens
122 ABCC1 4363
Affinity Capture-MS Homo sapiens
123 NCLN 56926
Affinity Capture-MS Homo sapiens
124 CDC45  
Affinity Capture-MS Homo sapiens
125 ACAD9 28976
Affinity Capture-MS Homo sapiens
126 MED23 9439
Reconstituted Complex Homo sapiens
127 Setdb1  
Affinity Capture-MS Mus musculus
128 CHD8 57680
Affinity Capture-Western Homo sapiens
129 NCAPG2 54892
Affinity Capture-MS Homo sapiens
130 AMBP 259
Affinity Capture-MS Homo sapiens
131 MAD2L1 4085
Affinity Capture-MS Homo sapiens
132 AKT1 207
Biochemical Activity Homo sapiens
133 SUCLG2 8801
Affinity Capture-MS Homo sapiens
134 PPFIA1 8500
Affinity Capture-MS Homo sapiens
135 ARAF 369
Affinity Capture-MS Homo sapiens
136 MED14  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
137 CXorf57  
Affinity Capture-MS Homo sapiens
138 MED11  
Affinity Capture-MS Homo sapiens
139 TBCD 6904
Affinity Capture-MS Homo sapiens
140 GRK5 2869
Affinity Capture-MS Homo sapiens
141 MED19  
Affinity Capture-MS Homo sapiens
142 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
143 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
144 POLR2F  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 WDR77 79084
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
146 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 CDK8 1024
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
148 TTC27 55622
Affinity Capture-MS Homo sapiens
149 VPS52 6293
Affinity Capture-MS Homo sapiens
150 ERH 2079
Affinity Capture-Western Homo sapiens
151 POLR2L 5441
Affinity Capture-MS Homo sapiens
152 STK38 11329
Affinity Capture-Western Homo sapiens
153 PRRC2A 7916
Affinity Capture-MS Homo sapiens
154 TCEA1 6917
Reconstituted Complex Homo sapiens
155 ALDH1B1 219
Affinity Capture-MS Homo sapiens
156 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
157 MED8  
Reconstituted Complex Homo sapiens
158 DNAJA3 9093
Affinity Capture-MS Homo sapiens
159 MED6  
Reconstituted Complex Homo sapiens
160 FANCI 55215
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
161 EXOC2 55770
Affinity Capture-MS Homo sapiens
162 GNL1 2794
Co-fractionation Homo sapiens
163 FANCA  
Affinity Capture-MS Homo sapiens
164 GTF2B 2959
Affinity Capture-MS Homo sapiens
165 FAR1 84188
Affinity Capture-MS Homo sapiens
166 MED16 10025
Reconstituted Complex Homo sapiens
167 NF1 4763
Affinity Capture-MS Homo sapiens
168 ETS2  
Affinity Capture-MS Homo sapiens
169 CDK9 1025
Biochemical Activity Homo sapiens
170 CIT 11113
Affinity Capture-MS Homo sapiens
171 CHTF18 63922
Affinity Capture-MS Homo sapiens
172 RPRD1B 58490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 ITPR1 3708
Affinity Capture-MS Homo sapiens
174 INTS3 65123
Reconstituted Complex Homo sapiens
175 MDN1 23195
Affinity Capture-MS Homo sapiens
176 YME1L1 10730
Affinity Capture-MS Homo sapiens
177 CT45A5  
Affinity Capture-MS Homo sapiens
178 PTPN13 5783
Affinity Capture-MS Homo sapiens
179 MED15  
Reconstituted Complex Homo sapiens
180 TIMM44 10469
Affinity Capture-MS Homo sapiens
181 EP300 2033
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CTDP1 is involved
PathwayEvidenceSource
Abortive elongation of HIV-1 transcript in the absence of Tat IEA Reactome
Disease IEA Reactome
Disease TAS Reactome
Formation of HIV elongation complex in the absence of HIV Tat IEA Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat IEA Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat TAS Reactome
Formation of RNA Pol II elongation complex TAS Reactome
Formation of the Early Elongation Complex TAS Reactome
Formation of the HIV-1 Early Elongation Complex IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
HIV elongation arrest and recovery IEA Reactome
HIV Infection IEA Reactome
HIV Infection TAS Reactome
HIV Life Cycle IEA Reactome
HIV Life Cycle TAS Reactome
HIV Transcription Elongation IEA Reactome
HIV Transcription Elongation TAS Reactome
Infectious disease IEA Reactome
Infectious disease TAS Reactome
Late Phase of HIV Life Cycle IEA Reactome
Late Phase of HIV Life Cycle TAS Reactome
Pausing and recovery of HIV elongation IEA Reactome
Pausing and recovery of Tat-mediated HIV elongation IEA Reactome
RNA Polymerase II Pre-transcription Events TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription Elongation TAS Reactome
Tat-mediated elongation of the HIV-1 transcript IEA Reactome
Tat-mediated elongation of the HIV-1 transcript TAS Reactome
Tat-mediated HIV elongation arrest and recovery IEA Reactome
TP53 Regulates Transcription of DNA Repair Genes TAS Reactome
Transcription of the HIV genome IEA Reactome
Transcription of the HIV genome TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Viral Infection Pathways IEA Reactome
Viral Infection Pathways TAS Reactome





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