Gene description for SHROOM2
Gene name shroom family member 2
Gene symbol SHROOM2
Other names/aliases APXL
HSAPXL
Species Homo sapiens
 Database cross references - SHROOM2
ExoCarta ExoCarta_357
Entrez Gene 357
HGNC 630
MIM 300103
UniProt Q13796  
 SHROOM2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SHROOM2
Molecular Function
    beta-catenin binding GO:0008013 ISS
    actin binding GO:0003779 ISS
    protein binding GO:0005515 IPI
    actin filament binding GO:0051015 ISS
    protein domain specific binding GO:0019904 IEA
    ligand-gated sodium channel activity GO:0015280 TAS
Biological Process
    melanosome organization GO:0032438 ISS
    camera-type eye morphogenesis GO:0048593 ISS
    sodium ion transmembrane transport GO:0035725 TAS
    cell migration GO:0016477 ISS
    cell-cell junction maintenance GO:0045217 IEA
    lens morphogenesis in camera-type eye GO:0002089 ISS
    cellular pigment accumulation GO:0043482 ISS
    brain development GO:0007420 ISS
    apical protein localization GO:0045176 ISS
    eye pigment granule organization GO:0008057 ISS
    negative regulation of actin filament depolymerization GO:0030835 IEA
    cell morphogenesis GO:0000902 ISS
    camera-type eye development GO:0043010 ISS
    actin filament bundle assembly GO:0051017 ISS
    establishment of melanosome localization GO:0032401 ISS
    ear development GO:0043583 ISS
Subcellular Localization
    cytoskeleton GO:0005856 ISS
    filamentous actin GO:0031941 IEA
    apical plasma membrane GO:0016324 ISS
    neuronal cell body GO:0043025 IEA
    extracellular exosome GO:0070062 IDA
    microtubule GO:0005874 IEA
    cortical actin cytoskeleton GO:0030864 ISS
    cell-cell adherens junction GO:0005913 ISS
    bicellular tight junction GO:0005923 ISS
    plasma membrane GO:0005886 ISS
 Experiment description of studies that identified SHROOM2 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SHROOM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SHROOM2 is involved
No pathways found





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