Gene description for ITPR1
Gene name inositol 1,4,5-trisphosphate receptor, type 1
Gene symbol ITPR1
Other names/aliases ACV
CLA4
INSP3R1
IP3R
IP3R1
PPP1R94
SCA15
SCA16
SCA29
Species Homo sapiens
 Database cross references - ITPR1
ExoCarta ExoCarta_3708
Vesiclepedia VP_3708
Entrez Gene 3708
HGNC 6180
MIM 147265
UniProt Q14643  
 ITPR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ITPR1
Molecular Function
    protein binding GO:0005515 IPI
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0005220 TAS
    phosphatidylinositol binding GO:0035091 ISS
    calcium ion transmembrane transporter activity GO:0015085 TAS
    intracellular ligand-gated calcium channel activity GO:0005218 ISS
    calcium channel inhibitor activity GO:0019855 IDA
Biological Process
    post-embryonic development GO:0009791 IEA
    release of sequestered calcium ion into cytosol GO:0051209 ISS
    blood coagulation GO:0007596 TAS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    endoplasmic reticulum calcium ion homeostasis GO:0032469 IEA
    platelet activation GO:0030168 TAS
    calcium ion transport GO:0006816 NAS
    calcium ion transmembrane transport GO:0070588 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    negative regulation of calcium-mediated signaling GO:0050849 IDA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    innate immune response GO:0045087 TAS
    regulation of insulin secretion GO:0050796 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    energy reserve metabolic process GO:0006112 TAS
    voluntary musculoskeletal movement GO:0050882 IEA
    inositol phosphate-mediated signaling GO:0048016 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    response to hypoxia GO:0001666 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    activation of phospholipase C activity GO:0007202 TAS
    signal transduction GO:0007165 TAS
    small molecule metabolic process GO:0044281 TAS
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 ISS
Subcellular Localization
    calcineurin complex GO:0005955 IEA
    membrane GO:0016020 IDA
    integral component of membrane GO:0016021 IEA
    postsynaptic density GO:0014069 IEA
    sarcoplasmic reticulum GO:0016529 IEA
    platelet dense tubular network membrane GO:0031095 TAS
    platelet dense tubular network GO:0031094 IDA
    nucleolus GO:0005730 IEA
    endoplasmic reticulum GO:0005783 NAS
    nuclear inner membrane GO:0005637 IEA
    platelet dense granule membrane GO:0031088 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified ITPR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ITPR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HOMER3 9454
Invivo Homo sapiens
Invitro Homo sapiens
2 EPB41L1 2036
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 STARD13 90627
Two-hybrid Homo sapiens
4 AHCYL1 10768
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 TRPC3  
Affinity Capture-Western Homo sapiens
6 TRPC4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
7 ITPR3 3710
Invivo Homo sapiens
8 GRM1  
Invivo Homo sapiens
9 FKBP1A 2280
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
10 HOMER1  
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
11 SDC2 6383
Affinity Capture-Western Homo sapiens
12 TRPC5  
Affinity Capture-Western Homo sapiens
13 TRPC2  
Affinity Capture-Western Homo sapiens
14 TRPC1  
Affinity Capture-Western Homo sapiens
15 HOMER2  
Invivo Homo sapiens
Invitro Homo sapiens
16 BCL2  
Affinity Capture-Western Homo sapiens
17 CA8  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
18 CABP1 9478
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
19 TRPC6 7225
Affinity Capture-Western Homo sapiens
20 BANK1  
Affinity Capture-Western Homo sapiens
21 RHOA 387
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
22 PRKG1 5592
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 MRVI1 10335
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
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