Gene description for CABP1
Gene name calcium binding protein 1
Gene symbol CABP1
Other names/aliases CALBRAIN
HCALB_BR
Species Homo sapiens
 Database cross references - CABP1
ExoCarta ExoCarta_9478
Entrez Gene 9478
HGNC 1384
MIM 605563
UniProt Q9NZU7  
 CABP1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for CABP1
Molecular Function
    nuclear localization sequence binding GO:0008139 ISS
    type 3 metabotropic glutamate receptor binding GO:0031800 IEA
    ion channel binding GO:0044325 IEA
    enzyme inhibitor activity GO:0004857 TAS
    protein homodimerization activity GO:0042803 IEA
    calcium-dependent protein binding GO:0048306 IPI
    protein domain specific binding GO:0019904 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of voltage-gated calcium channel activity GO:1901386 IEA
    negative regulation of cell communication by electrical coupling GO:0010651 IEA
    negative regulation of catalytic activity GO:0043086 TAS
    negative regulation of protein import into nucleus GO:0042308 ISS
Subcellular Localization
    cytosol GO:0005829 IEA
    neuronal cell body GO:0043025 IEA
    protein complex GO:0043234 IEA
    dendrite GO:0030425 IEA
    cytoplasmic side of plasma membrane GO:0009898 IEA
    postsynaptic density GO:0014069 IDA
    nucleus GO:0005634 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    postsynaptic membrane GO:0045211 IEA
    cell cortex GO:0005938 IEA
    Golgi membrane GO:0000139 IDA
    extracellular space GO:0005615 IDA
    plasma membrane GO:0005886 IDA
    cell junction GO:0030054 IEA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified CABP1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CABP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITPR1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
2 CACNA1A  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
3 CACNA1C  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
4 ITPR3 3710
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which CABP1 is involved
No pathways found





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