Gene description for SYNPO
Gene name synaptopodin
Gene symbol SYNPO
Other names/aliases -
Species Homo sapiens
 Database cross references - SYNPO
ExoCarta ExoCarta_11346
Vesiclepedia VP_11346
Entrez Gene 11346
HGNC 30672
MIM 608155
UniProt Q8N3V7  
 SYNPO identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SYNPO
Molecular Function
    actin binding GO:0003779 IBA
    actin binding GO:0003779 ISS
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of actin filament bundle assembly GO:0032233 IBA
    positive regulation of actin filament bundle assembly GO:0032233 ISS
    regulation of stress fiber assembly GO:0051492 ISS
    modification of dendritic spine GO:0098886 IBA
    spine apparatus assembly GO:1905355 IBA
Subcellular Localization
    stress fiber GO:0001725 IBA
    nucleus GO:0005634 IBA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    bicellular tight junction GO:0005923 IEA
    postsynaptic density GO:0014069 IEA
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 IDA
    actin cytoskeleton GO:0015629 ISS
    Z disc GO:0030018 IBA
    dendritic spine GO:0043197 TAS
    perikaryon GO:0043204 IEA
    spine apparatus GO:0097444 IBA
 Experiment description of studies that identified SYNPO in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SYNPO
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 ABCG2 9429
Affinity Capture-MS Homo sapiens
3 ACTR2 10097
Affinity Capture-MS Homo sapiens
4 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
5 SPTAN1 6709
Affinity Capture-MS Homo sapiens
6 SPECC1L 23384
Affinity Capture-MS Homo sapiens
7 PPP1CB 5500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TWF2 11344
Affinity Capture-MS Homo sapiens
9 Tpm1 22003
Affinity Capture-MS Mus musculus
10 CENPE 1062
Affinity Capture-MS Homo sapiens
11 CPM 1368
Affinity Capture-MS Homo sapiens
12 ARPC2 10109
Affinity Capture-MS Homo sapiens
13 TPM2 7169
Affinity Capture-MS Homo sapiens
14 ARPC4 10093
Affinity Capture-MS Homo sapiens
15 Calml3  
Affinity Capture-MS Mus musculus
16 APC  
Affinity Capture-MS Homo sapiens
17 DBN1 1627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LIMA1 51474
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 EPS15 2060
Affinity Capture-MS Homo sapiens
20 KIF20A 10112
Affinity Capture-MS Homo sapiens
21 ADD3 120
Affinity Capture-MS Homo sapiens
22 MYO5C 55930
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CFL1 1072
Affinity Capture-MS Homo sapiens
24 CLTB 1212
Affinity Capture-MS Homo sapiens
25 PPP1CC 5501
Affinity Capture-MS Homo sapiens
26 CAPZB 832
Affinity Capture-MS Homo sapiens
27 PPL 5493
Affinity Capture-MS Homo sapiens
28 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
29 CORO1B 57175
Affinity Capture-MS Homo sapiens
30 B3GNT2 10678
Affinity Capture-MS Homo sapiens
31 ZDHHC5 25921
Affinity Capture-MS Homo sapiens
32 ABLIM1 3983
Affinity Capture-MS Homo sapiens
33 MYO5B 4645
Affinity Capture-MS Homo sapiens
34 MYO1E 4643
Affinity Capture-MS Homo sapiens
35 ACTR3 10096
Affinity Capture-MS Homo sapiens
36 AP2A1 160
Affinity Capture-MS Homo sapiens
37 CD109 135228
Affinity Capture-MS Homo sapiens
38 PPP1R18 170954
Affinity Capture-MS Homo sapiens
39 IQGAP1 8826
Affinity Capture-MS Homo sapiens
40 YWHAG 7532
Two-hybrid Homo sapiens
41 TMEM201 199953
Affinity Capture-MS Homo sapiens
42 PHLDB2 90102
Affinity Capture-MS Homo sapiens
43 Flot2 14252
Affinity Capture-MS Mus musculus
44 CEP162  
Affinity Capture-MS Homo sapiens
45 MYO1B 4430
Affinity Capture-MS Homo sapiens
46 DNAJC7 7266
Affinity Capture-MS Homo sapiens
47 CD44 960
Affinity Capture-MS Homo sapiens
48 NAP1L4 4676
Affinity Capture-MS Homo sapiens
49 ARHGEF17 9828
Affinity Capture-MS Homo sapiens
50 ARPC5L 81873
Affinity Capture-MS Homo sapiens
51 NCK2 8440
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 NCK1 4690
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
53 TWF1 5756
Affinity Capture-MS Homo sapiens
54 CYBRD1 79901
Affinity Capture-MS Homo sapiens
55 Lima1  
Affinity Capture-MS Mus musculus
56 KIF14 9928
Affinity Capture-MS Homo sapiens
57 PRNP 5621
Affinity Capture-MS Homo sapiens
58 WDR1 9948
Affinity Capture-MS Homo sapiens
59 COBL  
Affinity Capture-MS Homo sapiens
60 CHMP4C 92421
Affinity Capture-MS Homo sapiens
61 PPP1CA 5499
Affinity Capture-MS Homo sapiens
62 MYO18A 399687
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 POC1A  
Affinity Capture-MS Homo sapiens
64 SORBS2  
Affinity Capture-MS Homo sapiens
65 LUZP1 7798
Affinity Capture-MS Homo sapiens
66 RAI14 26064
Affinity Capture-MS Homo sapiens
67 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
68 TMOD1  
Affinity Capture-MS Homo sapiens
69 NONO 4841
Two-hybrid Homo sapiens
70 MAPRE1 22919
Affinity Capture-MS Homo sapiens
71 RRAS2 22800
Affinity Capture-MS Homo sapiens
72 LRRFIP2 9209
Affinity Capture-MS Homo sapiens
73 MYH9 4627
Affinity Capture-MS Homo sapiens
74 ACTN4 81
Affinity Capture-MS Homo sapiens
75 ARHGAP11A  
Affinity Capture-MS Homo sapiens
76 FLNB 2317
Affinity Capture-MS Homo sapiens
77 BMP2K 55589
Affinity Capture-MS Homo sapiens
78 ACTB 60
Affinity Capture-MS Homo sapiens
79 GNAI2 2771
Affinity Capture-MS Homo sapiens
80 ARPC5 10092
Affinity Capture-MS Homo sapiens
81 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
82 STON2 85439
Affinity Capture-MS Homo sapiens
83 FLOT2 2319
Affinity Capture-MS Homo sapiens
84 GAK 2580
Affinity Capture-MS Homo sapiens
85 HMGB2 3148
Affinity Capture-MS Homo sapiens
86 GPRC5A 9052
Affinity Capture-MS Homo sapiens
87 TPRN 286262
Affinity Capture-MS Homo sapiens
88 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
89 BAG3 9531
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
90 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
92 ACTN1 87
Affinity Capture-MS Homo sapiens
93 CLINT1 9685
Affinity Capture-MS Homo sapiens
94 Myh9 17886
Affinity Capture-MS Mus musculus
95 ARPC1B 10095
Affinity Capture-MS Homo sapiens
96 ECT2 1894
Affinity Capture-MS Homo sapiens
97 PALM 5064
Affinity Capture-MS Homo sapiens
98 LMO7 4008
Affinity Capture-MS Homo sapiens
99 ARPC3 10094
Affinity Capture-MS Homo sapiens
100 YWHAZ 7534
Two-hybrid Homo sapiens
101 CTTN 2017
Affinity Capture-MS Homo sapiens
102 SPECC1 92521
Affinity Capture-MS Homo sapiens
103 MYO5A 4644
Affinity Capture-MS Homo sapiens
104 MYO19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 PACSIN3 29763
Affinity Capture-MS Homo sapiens
106 CD59 966
Affinity Capture-MS Homo sapiens
107 CORO1C 23603
Affinity Capture-MS Homo sapiens
108 BASP1 10409
Affinity Capture-MS Homo sapiens
109 MYO1C 4641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
111 NXF1 10482
Affinity Capture-RNA Homo sapiens
112 AP2M1 1173
Affinity Capture-MS Homo sapiens
113 ITPR1 3708
Affinity Capture-MS Homo sapiens
114 LZTS2 84445
Affinity Capture-MS Homo sapiens
115 CDK2 1017
Affinity Capture-MS Homo sapiens
116 TPM1 7168
Affinity Capture-MS Homo sapiens
117 CORO2A  
Affinity Capture-MS Homo sapiens
118 GNAS 2778
Affinity Capture-MS Homo sapiens
119 Flnb 286940
Affinity Capture-MS Mus musculus
120 MYC  
Affinity Capture-MS Homo sapiens
121 Tmod3 50875
Affinity Capture-MS Mus musculus
122 SEC16A 9919
Affinity Capture-MS Homo sapiens
123 TMOD3 29766
Affinity Capture-MS Homo sapiens
124 Actb 11461
Affinity Capture-MS Mus musculus
125 CFL2 1073
Affinity Capture-MS Homo sapiens
126 CGN  
Affinity Capture-MS Homo sapiens
127 RAF1 5894
Affinity Capture-MS Homo sapiens
128 CCDC101  
Two-hybrid Homo sapiens
129 FLII 2314
Affinity Capture-MS Homo sapiens
130 AKAP2 11217
Affinity Capture-MS Homo sapiens
131 CLTC 1213
Affinity Capture-MS Homo sapiens
132 MPRIP 23164
Affinity Capture-MS Homo sapiens
133 Ppp1cb 19046
Affinity Capture-MS Mus musculus
134 CAMK2G 818
Affinity Capture-MS Homo sapiens
135 FLOT1 10211
Affinity Capture-MS Homo sapiens
136 FARP1 10160
Affinity Capture-MS Homo sapiens
137 GSN 2934
Affinity Capture-MS Homo sapiens
138 Coro1c 23790
Affinity Capture-MS Mus musculus
139 SVIL 6840
Affinity Capture-MS Homo sapiens
140 SPTBN1 6711
Affinity Capture-MS Homo sapiens
141 PDLIM7 9260
Affinity Capture-MS Homo sapiens
142 NEXN 91624
Affinity Capture-MS Homo sapiens
143 DSG2 1829
Affinity Capture-MS Homo sapiens
144 CLIC1 1192
Affinity Capture-MS Homo sapiens
145 DAB2 1601
Affinity Capture-MS Homo sapiens
146 JUP 3728
Affinity Capture-MS Homo sapiens
147 PLEC 5339
Affinity Capture-MS Homo sapiens
148 SPTBN2 6712
Affinity Capture-MS Homo sapiens
149 TNFAIP1 7126
Affinity Capture-MS Homo sapiens
150 MISP 126353
Affinity Capture-MS Homo sapiens
151 Myo1c 17913
Affinity Capture-MS Mus musculus
152 SIPA1L3  
Affinity Capture-MS Homo sapiens
153 HLTF  
Affinity Capture-MS Homo sapiens
154 CAPZA2 830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
156 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
157 ITPR3 3710
Affinity Capture-MS Homo sapiens
158 LOC102724334 102724334
Cross-Linking-MS (XL-MS) Homo sapiens
159 GNB1 2782
Affinity Capture-MS Homo sapiens
160 Myh10 77579
Affinity Capture-MS Mus musculus
161 PPP1R9A  
Affinity Capture-MS Homo sapiens
162 AFAP1 60312
Affinity Capture-MS Homo sapiens
163 MOV10 4343
Affinity Capture-RNA Homo sapiens
164 INF2 64423
Affinity Capture-MS Homo sapiens
165 EEF1D 1936
Affinity Capture-MS Homo sapiens
166 DAPK3 1613
Affinity Capture-MS Homo sapiens
167 FLNA 2316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 CLTA 1211
Affinity Capture-MS Homo sapiens
169 CIT 11113
Affinity Capture-MS Homo sapiens
170 Flot1 14251
Affinity Capture-MS Mus musculus
171 ZBTB20 26137
Affinity Capture-MS Homo sapiens
172 MYO6 4646
Affinity Capture-MS Homo sapiens
173 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
174 ANXA2 302
Affinity Capture-MS Homo sapiens
175 SSH2  
Affinity Capture-MS Homo sapiens
176 Sept9  
Affinity Capture-MS Mus musculus
177 MAGI1  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
178 GNAI3 2773
Affinity Capture-MS Homo sapiens
179 PLCD3 113026
Affinity Capture-MS Homo sapiens
180 GNB2 2783
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SYNPO is involved
No pathways found





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