Gene description for LRRFIP2
Gene name leucine rich repeat (in FLII) interacting protein 2
Gene symbol LRRFIP2
Other names/aliases HUFI-2
Species Homo sapiens
 Database cross references - LRRFIP2
ExoCarta ExoCarta_9209
Vesiclepedia VP_9209
Entrez Gene 9209
HGNC 6703
MIM 614043
UniProt Q9Y608  
 LRRFIP2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for LRRFIP2
Molecular Function
    protein binding GO:0005515 IPI
    LRR domain binding GO:0030275 IPI
Biological Process
    regulation of DNA-templated transcription GO:0006355 IEA
    Wnt signaling pathway GO:0016055 IEA
 Experiment description of studies that identified LRRFIP2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for LRRFIP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATG16L1 55054
Affinity Capture-MS Homo sapiens
2 HECTD1 25831
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 Naa15 74838
Affinity Capture-MS Mus musculus
5 CRYGD  
Affinity Capture-MS Homo sapiens
6 MYL12A 10627
Affinity Capture-MS Homo sapiens
7 HDAC4  
Affinity Capture-MS Homo sapiens
8 TMPO 7112
Affinity Capture-MS Homo sapiens
9 PSMB10 5699
Affinity Capture-MS Homo sapiens
10 Tmod3 50875
Affinity Capture-MS Mus musculus
11 EIF4G3 8672
Co-fractionation Homo sapiens
12 KIF14 9928
Affinity Capture-MS Homo sapiens
13 Myh9 17886
Affinity Capture-MS Mus musculus
14 PSMC3 5702
Co-fractionation Homo sapiens
15 Lima1  
Affinity Capture-MS Mus musculus
16 Haus4  
Affinity Capture-MS Mus musculus
17 ABRA  
Affinity Capture-MS Homo sapiens
18 TMOD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 HSPA8 3312
Affinity Capture-MS Homo sapiens
20 ACTG1 71
Affinity Capture-MS Homo sapiens
21 SNX27 81609
Affinity Capture-MS Homo sapiens
22 TMOD3 29766
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CTNNB1 1499
Affinity Capture-MS Homo sapiens
24 TMEM147 10430
Affinity Capture-MS Homo sapiens
25 Myo1c 17913
Affinity Capture-MS Mus musculus
26 MYO18A 399687
Affinity Capture-MS Homo sapiens
27 Itga5 16402
Affinity Capture-MS Mus musculus
28 GRIN3B  
Affinity Capture-MS Homo sapiens
29 CAPZA2 830
Affinity Capture-MS Homo sapiens
30 BTF3 689
Affinity Capture-MS Homo sapiens
31 CAPZA1 829
Co-fractionation Homo sapiens
32 KARS 3735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
34 MYO19  
Affinity Capture-MS Homo sapiens
35 RNF138  
Affinity Capture-MS Homo sapiens
36 ACTC1 70
Affinity Capture-MS Homo sapiens
37 ACTB 60
Proximity Label-MS Homo sapiens
38 Actb 11461
Affinity Capture-MS Mus musculus
39 RNF6  
Affinity Capture-MS Homo sapiens
40 ISG15 9636
Affinity Capture-MS Homo sapiens
41 Gorasp1  
Affinity Capture-MS Mus musculus
42 MYO5C 55930
Affinity Capture-MS Homo sapiens
43 Myh10 77579
Affinity Capture-MS Mus musculus
44 Uso1 56041
Affinity Capture-MS Mus musculus
45 FAM133A 286499
Affinity Capture-MS Homo sapiens
46 CDK2 1017
Affinity Capture-MS Homo sapiens
47 UBD  
Affinity Capture-Western Homo sapiens
48 Samm50  
Affinity Capture-MS Mus musculus
49 SYNPO 11346
Affinity Capture-MS Homo sapiens
50 MYC  
Affinity Capture-MS Homo sapiens
51 Dctn3  
Affinity Capture-MS Mus musculus
52 MYH9 4627
Affinity Capture-MS Homo sapiens
53 DYRK1A 1859
Affinity Capture-MS Homo sapiens
54 OGT 8473
Reconstituted Complex Homo sapiens
55 RXRA 6256
Affinity Capture-MS Homo sapiens
56 STAT3 6774
Affinity Capture-MS Homo sapiens
57 MYD88 4615
Affinity Capture-Western Homo sapiens
58 PPIE 10450
Affinity Capture-MS Homo sapiens
59 RLIM 51132
Affinity Capture-MS Homo sapiens
60 Flot1 14251
Affinity Capture-MS Mus musculus
61 ATPAF2 91647
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
62 CENPQ  
Affinity Capture-MS Homo sapiens
63 IQGAP1 8826
Affinity Capture-MS Homo sapiens
64 FLII 2314
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
65 PSMC2 5701
Co-fractionation Homo sapiens
66 Ufl1  
Affinity Capture-MS Mus musculus
67 CALM3 808
Affinity Capture-MS Homo sapiens
68 Coro1c 23790
Affinity Capture-MS Mus musculus
69 YWHAE 7531
Affinity Capture-MS Homo sapiens
70 RNF26  
Affinity Capture-MS Homo sapiens
71 PSMC4 5704
Co-fractionation Homo sapiens
72 Ppp1cb 19046
Affinity Capture-MS Mus musculus
73 Flot2 14252
Affinity Capture-MS Mus musculus
74 RASSF7  
Affinity Capture-MS Homo sapiens
75 SH2D1A 4068
Affinity Capture-MS Homo sapiens
76 CAPZB 832
Affinity Capture-MS Homo sapiens
77 DBN1 1627
Affinity Capture-MS Homo sapiens
78 Wbp11  
Affinity Capture-MS Mus musculus
79 TMOD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CTTN 2017
Affinity Capture-MS Homo sapiens
81 SMUG1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LRRFIP2 is involved
No pathways found





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