Gene description for Coro1c
Gene name coronin, actin binding protein 1C
Gene symbol Coro1c
Other names/aliases AL022675
AW455561
AW548837
Species Mus musculus
 Database cross references - Coro1c
ExoCarta ExoCarta_23790
Vesiclepedia VP_23790
Entrez Gene 23790
UniProt Q9WUM4  
 Coro1c identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Coro1c
Molecular Function
    small GTPase binding GO:0031267 IPI
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IEA
    actin filament binding GO:0051015 ISO
Biological Process
    actin cortical patch assembly GO:0000147 TAS
    neural crest cell migration GO:0001755 IBA
    neural crest cell migration GO:0001755 IEA
    neural crest cell migration GO:0001755 ISO
    regulation of protein phosphorylation GO:0001932 ISO
    negative regulation of protein phosphorylation GO:0001933 ISO
    phagocytosis GO:0006909 TAS
    actin filament organization GO:0007015 IBA
    regulation of epithelial cell migration GO:0010632 ISO
    negative regulation of epithelial cell migration GO:0010633 IEA
    negative regulation of epithelial cell migration GO:0010633 ISO
    regulation of fibroblast migration GO:0010762 IMP
    endosomal transport GO:0016197 ISO
    endosomal transport GO:0016197 ISS
    ventricular system development GO:0021591 IMP
    corpus callosum development GO:0022038 IMP
    actin cytoskeleton organization GO:0030036 TAS
    negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044387 ISO
    establishment of protein localization GO:0045184 IGI
    establishment of protein localization GO:0045184 IMP
    regulation of focal adhesion assembly GO:0051893 ISO
    negative regulation of focal adhesion assembly GO:0051895 IEA
    negative regulation of focal adhesion assembly GO:0051895 ISO
    membrane fission GO:0090148 ISO
    membrane fission GO:0090148 ISS
    activation of GTPase activity GO:0090630 IGI
    activation of GTPase activity GO:0090630 IMP
    endosome membrane tubulation GO:0097750 ISO
    endosome membrane tubulation GO:0097750 ISS
    endosome fission GO:0140285 ISO
    endosome fission GO:0140285 ISS
    regulation of substrate adhesion-dependent cell spreading GO:1900024 ISO
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 IEA
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 ISO
    regulation of ruffle assembly GO:1900027 IGI
    positive regulation of lamellipodium morphogenesis GO:2000394 IEA
    positive regulation of lamellipodium morphogenesis GO:2000394 ISO
Subcellular Localization
    cytoskeleton GO:0005856 IDA
    cytoskeleton GO:0005856 TAS
    cell cortex GO:0005938 IEA
    endosome membrane GO:0010008 ISO
    endosome membrane GO:0010008 ISS
    actin cytoskeleton GO:0015629 IEA
    actin cytoskeleton GO:0015629 ISO
    lateral plasma membrane GO:0016328 IEA
    lateral plasma membrane GO:0016328 ISO
    flotillin complex GO:0016600 IDA
    lamellipodium GO:0030027 IEA
    lamellipodium GO:0030027 ISO
    vesicle GO:0031982 ISO
    ruffle membrane GO:0032587 IEA
 Experiment description of studies that identified Coro1c in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Coro1c
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP2A 27243
Affinity Capture-MS Homo sapiens
2 ACTR2 10097
Affinity Capture-MS Homo sapiens
3 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
4 DECR2 26063
Affinity Capture-MS Homo sapiens
5 ZDHHC5 25921
Affinity Capture-MS Homo sapiens
6 TWF2 11344
Affinity Capture-MS Homo sapiens
7 RAB1A 5861
Affinity Capture-MS Homo sapiens
8 ARPC5L 81873
Affinity Capture-MS Homo sapiens
9 CPM 1368
Affinity Capture-MS Homo sapiens
10 ARPC2 10109
Affinity Capture-MS Homo sapiens
11 BEGAIN  
Affinity Capture-MS Homo sapiens
12 TPM2 7169
Affinity Capture-MS Homo sapiens
13 ARPC4 10093
Affinity Capture-MS Homo sapiens
14 DBN1 1627
Affinity Capture-MS Homo sapiens
15 LIMA1 51474
Affinity Capture-MS Homo sapiens
16 CALM1 801
Affinity Capture-MS Homo sapiens
17 FMNL2 114793
Affinity Capture-MS Homo sapiens
18 CFL1 1072
Affinity Capture-MS Homo sapiens
19 CLTB 1212
Affinity Capture-MS Homo sapiens
20 PI4KA 5297
Affinity Capture-MS Homo sapiens
21 AMOTL1 154810
Affinity Capture-MS Homo sapiens
22 PPP1CC 5501
Affinity Capture-MS Homo sapiens
23 CAPZB 832
Affinity Capture-MS Homo sapiens
24 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
25 CORO1B 57175
Affinity Capture-MS Homo sapiens
26 PRKCDBP 112464
Affinity Capture-MS Homo sapiens
27 ABLIM1 3983
Affinity Capture-MS Homo sapiens
28 MYO5B 4645
Affinity Capture-MS Homo sapiens
29 ACTR3 10096
Affinity Capture-MS Homo sapiens
30 AP2A1 160
Affinity Capture-MS Homo sapiens
31 YES1 7525
Affinity Capture-MS Homo sapiens
32 CALD1 800
Affinity Capture-MS Homo sapiens
33 ADD1 118
Affinity Capture-MS Homo sapiens
34 FAM126A 84668
Affinity Capture-MS Homo sapiens
35 RHOA 387
Affinity Capture-MS Homo sapiens
36 CEP162  
Affinity Capture-MS Homo sapiens
37 MYO1B 4430
Affinity Capture-MS Homo sapiens
38 TMOD1  
Affinity Capture-MS Homo sapiens
39 TPRN 286262
Affinity Capture-MS Homo sapiens
40 Eed  
Affinity Capture-MS Mus musculus
41 PALM 5064
Affinity Capture-MS Homo sapiens
42 ARHGEF17 9828
Affinity Capture-MS Homo sapiens
43 TWF1 5756
Affinity Capture-MS Homo sapiens
44 RHOG 391
Affinity Capture-MS Homo sapiens
45 TFRC 7037
Affinity Capture-MS Homo sapiens
46 CYBRD1 79901
Affinity Capture-MS Homo sapiens
47 WDR1 9948
Affinity Capture-MS Homo sapiens
48 COBL  
Affinity Capture-MS Homo sapiens
49 BSG 682
Affinity Capture-MS Homo sapiens
50 NF2 4771
Affinity Capture-MS Homo sapiens
51 PHLDB2 90102
Affinity Capture-MS Homo sapiens
52 MYO18A 399687
Affinity Capture-MS Homo sapiens
53 Foxp3  
Affinity Capture-MS Mus musculus
54 CAPZA1 829
Affinity Capture-MS Homo sapiens
55 SORBS2  
Affinity Capture-MS Homo sapiens
56 LUZP1 7798
Affinity Capture-MS Homo sapiens
57 RAI14 26064
Affinity Capture-MS Homo sapiens
58 RALA 5898
Affinity Capture-MS Homo sapiens
59 PLD1 5337
Affinity Capture-MS Homo sapiens
60 LYN 4067
Affinity Capture-MS Homo sapiens
61 RRAS2 22800
Affinity Capture-MS Homo sapiens
62 LRRFIP2 9209
Affinity Capture-MS Homo sapiens
63 RAP1B 5908
Affinity Capture-MS Homo sapiens
64 CHMP4B 128866
Affinity Capture-MS Homo sapiens
65 FYN 2534
Affinity Capture-MS Homo sapiens
66 TTC7A 57217
Affinity Capture-MS Homo sapiens
67 ACTN4 81
Affinity Capture-MS Homo sapiens
68 ARHGAP11A  
Affinity Capture-MS Homo sapiens
69 RAP1A 5906
Affinity Capture-MS Homo sapiens
70 HACE1 57531
Affinity Capture-MS Homo sapiens
71 DCTN1 1639
Affinity Capture-MS Homo sapiens
72 FLNB 2317
Affinity Capture-MS Homo sapiens
73 LRRFIP1 9208
Affinity Capture-MS Homo sapiens
74 FLOT2 2319
Affinity Capture-MS Homo sapiens
75 CCNY 219771
Affinity Capture-MS Homo sapiens
76 ACTG1 71
Affinity Capture-MS Homo sapiens
77 ST5 6764
Affinity Capture-MS Homo sapiens
78 HMGB2 3148
Affinity Capture-MS Homo sapiens
79 GPRC5A 9052
Affinity Capture-MS Homo sapiens
80 DST 667
Affinity Capture-MS Homo sapiens
81 CSNK1G3 1456
Affinity Capture-MS Homo sapiens
82 Mycbp2 105689
Affinity Capture-MS Mus musculus
83 ACTBL2 345651
Affinity Capture-MS Homo sapiens
84 ARPC1B 10095
Affinity Capture-MS Homo sapiens
85 ARPC3 10094
Affinity Capture-MS Homo sapiens
86 RALB 5899
Affinity Capture-MS Homo sapiens
87 AHNAK 79026
Affinity Capture-MS Homo sapiens
88 LMTK2 22853
Affinity Capture-MS Homo sapiens
89 CTTN 2017
Affinity Capture-MS Homo sapiens
90 SPECC1 92521
Affinity Capture-MS Homo sapiens
91 MYO5A 4644
Affinity Capture-MS Homo sapiens
92 MYO19  
Affinity Capture-MS Homo sapiens
93 PACSIN3 29763
Affinity Capture-MS Homo sapiens
94 CD59 966
Affinity Capture-MS Homo sapiens
95 BASP1 10409
Affinity Capture-MS Homo sapiens
96 MYO1C 4641
Affinity Capture-MS Homo sapiens
97 AP2M1 1173
Affinity Capture-MS Homo sapiens
98 CCDC50 152137
Affinity Capture-MS Homo sapiens
99 LZTS2 84445
Affinity Capture-MS Homo sapiens
100 GNA11 2767
Affinity Capture-MS Homo sapiens
101 TPM1 7168
Affinity Capture-MS Homo sapiens
102 CORO2A  
Affinity Capture-MS Homo sapiens
103 GNAS 2778
Affinity Capture-MS Homo sapiens
104 TMEM237 65062
Affinity Capture-MS Homo sapiens
105 ATP6V1A 523
Affinity Capture-MS Homo sapiens
106 TMOD3 29766
Affinity Capture-MS Homo sapiens
107 RPL22 6146
Affinity Capture-MS Homo sapiens
108 DSTN 11034
Affinity Capture-MS Homo sapiens
109 FLII 2314
Affinity Capture-MS Homo sapiens
110 AKAP2 11217
Affinity Capture-MS Homo sapiens
111 CLTC 1213
Affinity Capture-MS Homo sapiens
112 MPRIP 23164
Affinity Capture-MS Homo sapiens
113 KIDINS220 57498
Affinity Capture-MS Homo sapiens
114 SYNPO 11346
Affinity Capture-MS Homo sapiens
115 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
116 FLOT1 10211
Affinity Capture-MS Homo sapiens
117 FARP1 10160
Affinity Capture-MS Homo sapiens
118 GSN 2934
Affinity Capture-MS Homo sapiens
119 JUP 3728
Affinity Capture-MS Homo sapiens
120 SPTBN1 6711
Affinity Capture-MS Homo sapiens
121 NEXN 91624
Affinity Capture-MS Homo sapiens
122 SPTAN1 6709
Affinity Capture-MS Homo sapiens
123 CLIC1 1192
Affinity Capture-MS Homo sapiens
124 ARPC5 10092
Affinity Capture-MS Homo sapiens
125 SVIL 6840
Affinity Capture-MS Homo sapiens
126 EIF3I 8668
Affinity Capture-MS Homo sapiens
127 Tmem173  
Proximity Label-MS Mus musculus
128 XPR1 9213
Affinity Capture-MS Homo sapiens
129 Atxn1  
Affinity Capture-MS Mus musculus
130 CDC37 11140
Affinity Capture-MS Homo sapiens
131 PLCD3 113026
Affinity Capture-MS Homo sapiens
132 Kctd13  
Affinity Capture-MS Mus musculus
133 CAPZA2 830
Affinity Capture-MS Homo sapiens
134 CFL2 1073
Affinity Capture-MS Homo sapiens
135 PPP1R9B 84687
Affinity Capture-MS Homo sapiens
136 Herc2  
Affinity Capture-MS Mus musculus
137 Mettl21e  
Affinity Capture-MS Mus musculus
138 PPP1R9A  
Affinity Capture-MS Homo sapiens
139 AFAP1 60312
Affinity Capture-MS Homo sapiens
140 INF2 64423
Affinity Capture-MS Homo sapiens
141 EEF1D 1936
Affinity Capture-MS Homo sapiens
142 DAPK3 1613
Affinity Capture-MS Homo sapiens
143 FRS2 10818
Affinity Capture-MS Homo sapiens
144 FLNA 2316
Affinity Capture-MS Homo sapiens
145 CLTA 1211
Affinity Capture-MS Homo sapiens
146 MYO5C 55930
Affinity Capture-MS Homo sapiens
147 MISP 126353
Affinity Capture-MS Homo sapiens
148 KRAS 3845
Affinity Capture-MS Homo sapiens
149 PCNXL3 399909
Affinity Capture-MS Homo sapiens
150 CD44 960
Affinity Capture-MS Homo sapiens
151 RAC1 5879
Affinity Capture-MS Homo sapiens
152 SSH2  
Affinity Capture-MS Homo sapiens
153 CAV1 857
Affinity Capture-MS Homo sapiens
154 DSG2 1829
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Coro1c is involved
No pathways found





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