Gene description for ABLIM1
Gene name actin binding LIM protein 1
Gene symbol ABLIM1
Other names/aliases ABLIM
LIMAB1
LIMATIN
abLIM-1
Species Homo sapiens
 Database cross references - ABLIM1
ExoCarta ExoCarta_3983
Vesiclepedia VP_3983
Entrez Gene 3983
HGNC 78
MIM 602330
UniProt O14639  
 ABLIM1 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ABLIM1
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    lamellipodium assembly GO:0030032 IMP
    cytoskeleton organization GO:0007010 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    axon guidance GO:0007411 TAS
    organ morphogenesis GO:0009887 TAS
    visual perception GO:0007601 TAS
    cilium assembly GO:0042384 IMP
Subcellular Localization
    lamellipodium GO:0030027 IDA
    stress fiber GO:0001725 IDA
    cytoplasm GO:0005737 IEA
    actin cytoskeleton GO:0015629 TAS
 Experiment description of studies that identified ABLIM1 in exosomes
1
Experiment ID 834
ISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
ISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ABLIM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF2 7186
Two-hybrid Homo sapiens
2 LDOC1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
3 SFN 2810
Affinity Capture-MS Homo sapiens
4 GOLGA2 2801
Two-hybrid Homo sapiens
5 KRT15 3866
Two-hybrid Homo sapiens
6 TSC22D4 81628
Two-hybrid Homo sapiens
7 VIM 7431
Two-hybrid Homo sapiens
8 KCNJ12 3768
Affinity Capture-MS Homo sapiens
9 USHBP1  
Two-hybrid Homo sapiens
10 NDP52  
Two-hybrid Homo sapiens
11 HOOK2  
Two-hybrid Homo sapiens
12 KIAA1446  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ABLIM1 is involved
PathwayEvidenceSource
DCC mediated attractive signaling TAS Reactome





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