Gene description for Flnb
Gene name filamin, beta
Gene symbol Flnb
Other names/aliases AL024016
Fln-b
Species Mus musculus
 Database cross references - Flnb
ExoCarta ExoCarta_286940
Entrez Gene 286940
UniProt Q80X90  
 Flnb identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Flnb
Molecular Function
    identical protein binding GO:0042802 ISO
    actin binding GO:0003779 IEA
    poly(A) RNA binding GO:0044822 ISO
    protein binding GO:0005515 IPI
Biological Process
    keratinocyte development GO:0003334 IMP
    cell differentiation GO:0030154 IEA
    epithelial cell morphogenesis GO:0003382 IMP
    skeletal muscle tissue development GO:0007519 IDA
    actin cytoskeleton organization GO:0030036 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IEA
    focal adhesion GO:0005925 ISO
    plasma membrane GO:0005886 ISO
    brush border GO:0005903 IDA
    stress fiber GO:0001725 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Flnb in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Flnb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Flnb is involved
PathwayEvidenceSource
ISG15 antiviral mechanism IEA Reactome





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