Gene description for LUZP1
Gene name leucine zipper protein 1
Gene symbol LUZP1
Other names/aliases LUZP
Species Homo sapiens
 Database cross references - LUZP1
ExoCarta ExoCarta_7798
Vesiclepedia VP_7798
Entrez Gene 7798
HGNC 14985
MIM 601422
UniProt Q86V48  
 LUZP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for LUZP1
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 ISS
    actin filament binding GO:0051015 IDA
Biological Process
    ventricular septum development GO:0003281 IEA
    apical constriction GO:0003383 ISS
    neural fold bending GO:0021503 IEA
    contractile ring contraction GO:0036213 IMP
    stress fiber assembly GO:0043149 IMP
    artery development GO:0060840 IEA
    regulation of protein complex stability GO:0061635 ISS
    negative regulation of cilium assembly GO:1902018 IMP
    protein localization to actin cytoskeleton GO:1903119 IBA
Subcellular Localization
    chromosome, centromeric region GO:0000775 IDA
    stress fiber GO:0001725 IDA
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    actin filament GO:0005884 IDA
    actin cytoskeleton GO:0015629 IBA
    membrane GO:0016020 HDA
    midbody GO:0030496 IDA
    ciliary basal body GO:0036064 IDA
    spindle midzone GO:0051233 IDA
    extracellular exosome GO:0070062 HDA
    tight junction GO:0070160 ISS
    CERF complex GO:0090537 ISS
 Experiment description of studies that identified LUZP1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for LUZP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTR2 10097
Affinity Capture-MS Homo sapiens
2 LUZP4  
Affinity Capture-MS Homo sapiens
3 ISG15 9636
Affinity Capture-MS Homo sapiens
4 PPP1CB 5500
Affinity Capture-MS Homo sapiens
5 AAK1 22848
Affinity Capture-MS Homo sapiens
6 DHCR24 1718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ATG5 9474
Proximity Label-MS Homo sapiens
8 SYCE1  
Affinity Capture-MS Homo sapiens
9 SP1  
Affinity Capture-MS Homo sapiens
10 Calml3  
Affinity Capture-MS Mus musculus
11 ACTC1 70
Proximity Label-MS Homo sapiens
12 DBN1 1627
Affinity Capture-MS Homo sapiens
13 KIF20A 10112
Affinity Capture-MS Homo sapiens
14 MYO5C 55930
Affinity Capture-MS Homo sapiens
15 CAMSAP2  
Proximity Label-MS Homo sapiens
16 Actb 11461
Affinity Capture-MS Mus musculus
17 CAPZB 832
Affinity Capture-MS Homo sapiens
18 DYRK1A 1859
Affinity Capture-MS Homo sapiens
19 CALD1 800
Affinity Capture-MS Homo sapiens
20 FBXW7  
Affinity Capture-MS Homo sapiens
21 PRC1 9055
Affinity Capture-MS Homo sapiens
22 IQGAP1 8826
Affinity Capture-MS Homo sapiens
23 CALM3 808
Affinity Capture-MS Homo sapiens
24 FBXW8 26259
Affinity Capture-MS Homo sapiens
25 YWHAG 7532
Affinity Capture-MS Homo sapiens
26 Flot2 14252
Affinity Capture-MS Mus musculus
27 ATRX 546
Cross-Linking-MS (XL-MS) Homo sapiens
28 YWHAH 7533
Affinity Capture-MS Homo sapiens
29 TNFRSF1B  
Affinity Capture-MS Homo sapiens
30 MAD2L1 4085
Affinity Capture-MS Homo sapiens
31 Lima1  
Affinity Capture-MS Mus musculus
32 Tmed10 68581
Affinity Capture-MS Mus musculus
33 HSPA8 3312
Affinity Capture-MS Homo sapiens
34 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 CHMP4C 92421
Affinity Capture-MS Homo sapiens
36 TOLLIP 54472
Proximity Label-MS Homo sapiens
37 KRT19 3880
Proximity Label-MS Homo sapiens
38 MYO18A 399687
Affinity Capture-MS Homo sapiens
39 MIB1 57534
Proximity Label-MS Homo sapiens
40 BAG2 9532
Affinity Capture-MS Homo sapiens
41 MCC 4163
Affinity Capture-MS Homo sapiens
42 MAPRE1 22919
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
43 PPIP5K2 23262
Affinity Capture-MS Homo sapiens
44 CDH1 999
Proximity Label-MS Homo sapiens
45 CHMP4B 128866
Affinity Capture-MS Homo sapiens
46 C9orf41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 MYH9 4627
Affinity Capture-MS Homo sapiens
48 DCTN1 1639
Proximity Label-MS Homo sapiens
49 KIF11 3832
Affinity Capture-MS Homo sapiens
50 ACTB 60
Proximity Label-MS Homo sapiens
51 SCOC 60592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 NINL  
Proximity Label-MS Homo sapiens
53 GFAP 2670
Affinity Capture-MS Homo sapiens
54 RMDN3 55177
Proximity Label-MS Homo sapiens
55 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 CDC14A  
Proximity Label-MS Homo sapiens
57 PHLPP1  
Proximity Label-MS Homo sapiens
58 LIMA1 51474
Affinity Capture-MS Homo sapiens
59 DAPK3 1613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 BRF1  
Affinity Capture-MS Homo sapiens
61 Myh9 17886
Affinity Capture-MS Mus musculus
62 FLNA 2316
Affinity Capture-MS Homo sapiens
63 MGME1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 ECT2 1894
Affinity Capture-MS Homo sapiens
65 CTTN 2017
Affinity Capture-MS Homo sapiens
66 Itga5 16402
Affinity Capture-MS Mus musculus
67 PTEN 5728
Affinity Capture-MS Homo sapiens
68 BTF3 689
Affinity Capture-MS Homo sapiens
69 MYO19  
Affinity Capture-MS Homo sapiens
70 HOOK3 84376
Proximity Label-MS Homo sapiens
71 DUSP16  
Affinity Capture-MS Homo sapiens
72 CDK2 1017
Affinity Capture-MS Homo sapiens
73 UBE2D2 7322
Affinity Capture-MS Homo sapiens
74 SYNPO 11346
Affinity Capture-MS Homo sapiens
75 TADA2A  
Affinity Capture-MS Homo sapiens
76 Flnb 286940
Affinity Capture-MS Mus musculus
77 MYC  
Affinity Capture-MS Homo sapiens
78 BICD2 23299
Proximity Label-MS Homo sapiens
79 Tpx2  
Affinity Capture-MS Mus musculus
80 ZMYND8 23613
Affinity Capture-MS Homo sapiens
81 SCGN  
Affinity Capture-MS Homo sapiens
82 HSPA1A 3303
Affinity Capture-MS Homo sapiens
83 NDC80 10403
Proximity Label-MS Homo sapiens
84 BICD1 636
Proximity Label-MS Homo sapiens
85 PCM1 5108
Proximity Label-MS Homo sapiens
86 CCDC88A 55704
Affinity Capture-MS Homo sapiens
87 Ppp1cb 19046
Affinity Capture-MS Mus musculus
88 NEUROG3  
Affinity Capture-MS Homo sapiens
89 HAUS3  
Affinity Capture-MS Homo sapiens
90 SEC24B 10427
Affinity Capture-MS Homo sapiens
91 Coro1c 23790
Affinity Capture-MS Mus musculus
92 PDLIM7 9260
Affinity Capture-MS Homo sapiens
93 KIF2A 3796
Proximity Label-MS Homo sapiens
94 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
95 Tmod3 50875
Affinity Capture-MS Mus musculus
96 KIF14 9928
Affinity Capture-MS Homo sapiens
97 PLEC 5339
Affinity Capture-MS Homo sapiens
98 KLHDC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 EZR 7430
Proximity Label-MS Homo sapiens
100 Myo1c 17913
Affinity Capture-MS Mus musculus
101 CUL5 8065
Affinity Capture-MS Homo sapiens
102 CAPZA2 830
Affinity Capture-MS Homo sapiens
103 HSPB1 3315
Two-hybrid Homo sapiens
104 MAPRE3  
Proximity Label-MS Homo sapiens
105 AARSD1 80755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 Myh10 77579
Affinity Capture-MS Mus musculus
107 RNF38  
Affinity Capture-MS Homo sapiens
108 BAG5 9529
Affinity Capture-MS Homo sapiens
109 EYA4 2070
Affinity Capture-MS Homo sapiens
110 TRIP4 9325
Affinity Capture-MS Homo sapiens
111 CEP135  
Proximity Label-MS Homo sapiens
112 PINK1  
Affinity Capture-MS Homo sapiens
113 CIT 11113
Affinity Capture-MS Homo sapiens
114 KXD1 79036
Affinity Capture-MS Homo sapiens
115 Sept9  
Affinity Capture-MS Mus musculus
116 RPA3 6119
Proximity Label-MS Homo sapiens
117 NIN 51199
Proximity Label-MS Homo sapiens
118 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LUZP1 is involved
No pathways found





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