Experiment description of studies that identified HOOK3 in sEVs

1 Experiment ID 488 MISEV standards ✔ EM Biophysical techniques ✔ CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 36408942     Organism Homo sapiens Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." Journal name Proteomics Publication year 2023 Sample Mesenchymal stem cells Sample name UCMSC Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

2 Experiment ID 834 MISEV standards ✔ EM Biophysical techniques ✔ LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35333565     Organism Homo sapiens Experiment description LAMP2A regulates the loading of proteins into exosomes Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P" Journal name Sci Adv Publication year 2022 Sample Retinal pigment epithelial cells Sample name ARPE-19 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry

3 Experiment ID 835 MISEV standards ✔ EM Biophysical techniques ✔ CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35333565     Organism Homo sapiens Experiment description LAMP2A regulates the loading of proteins into exosomes Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P" Journal name Sci Adv Publication year 2022 Sample Retinal pigment epithelial cells Sample name ARPE-19 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry

Protein-protein interactions for HOOK3

Protein Interactor ExoCarta ID Identification method PubMed Species 1 HNRNPH1 3187 Proximity Label-MS Homo sapiens 2 KRT37 8688 Affinity Capture-MS Homo sapiens 3 DLG5 9231 Proximity Label-MS Homo sapiens 4 VPS41 27072 Affinity Capture-Western Homo sapiens 5 GFPT1 2673 Proximity Label-MS Homo sapiens 6 HOOK1   Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Proximity Label-MS Homo sapiens Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Proximity Label-MS Homo sapiens Affinity Capture-MS Homo sapiens 7 KLC2 64837 Proximity Label-MS Homo sapiens 8 CLIP1 6249 Affinity Capture-MS Homo sapiens 9 AAK1 22848 Proximity Label-MS Homo sapiens 10 ALMS1   Proximity Label-MS Homo sapiens 11 SYCE1   Affinity Capture-MS Homo sapiens 12 TPD52L2 7165 Proximity Label-MS Homo sapiens 13 ACOT9 23597 Proximity Label-MS Homo sapiens 14 DYNC1I2 1781 Proximity Label-MS Homo sapiens Proximity Label-MS Homo sapiens 15 MTPAP 55149 Proximity Label-MS Homo sapiens 16 APC   Proximity Label-MS Homo sapiens 17 GFAP 2670 Affinity Capture-MS Homo sapiens 18 FAM21A 387680 Proximity Label-MS Homo sapiens 19 MCCC1 56922 Proximity Label-MS Homo sapiens 20 KIF5B 3799 Proximity Label-MS Homo sapiens 21 Rab5c 19345 Affinity Capture-MS Mus musculus 22 HOOK2   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens 23 ANKRD28 23243 Proximity Label-MS Homo sapiens 24 CEP97 79598 Proximity Label-MS Homo sapiens 25 WDR62   Proximity Label-MS Homo sapiens 26 EIF4ENIF1 56478 Two-hybrid Homo sapiens 27 STRN 6801 Proximity Label-MS Homo sapiens 28 CDC16 8881 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 29 CORO1B 57175 Proximity Label-MS Homo sapiens 30 RELA 5970 Proximity Label-MS Homo sapiens 31 SYCE3   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 32 CGN   Proximity Label-MS Homo sapiens 33 PC 5091 Proximity Label-MS Homo sapiens 34 DYNC1LI2 1783 Proximity Label-MS Homo sapiens Proximity Label-MS Homo sapiens 35 IARS2 55699 Proximity Label-MS Homo sapiens 36 ZC3H7A   Proximity Label-MS Homo sapiens 37 Zbtb48   Affinity Capture-MS Mus musculus 38 RBM14 10432 Proximity Label-MS Homo sapiens 39 FNTB 2342 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 40 CPD 1362 Proximity Label-MS Homo sapiens 41 TBC1D23 55773 Proximity Label-MS Homo sapiens 42 KRI1   Proximity Label-MS Homo sapiens 43 ARHGEF10 9639 Affinity Capture-MS Homo sapiens 44 KRT31 3881 Affinity Capture-MS Homo sapiens 45 RCN2 5955 Proximity Label-MS Homo sapiens 46 KLC4 89953 Proximity Label-MS Homo sapiens 47 ITGA8 8516 Affinity Capture-MS Homo sapiens 48 KIAA0226   Affinity Capture-MS Homo sapiens 49 WASL 8976 Co-fractionation Homo sapiens 50 HAP1   Affinity Capture-MS Homo sapiens 51 KLHL20   Affinity Capture-MS Homo sapiens 52 VPS16 64601 Affinity Capture-Western Homo sapiens 53 PPP6R3 55291 Proximity Label-MS Homo sapiens 54 AKTIP   Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens Proximity Label-MS Homo sapiens 55 NBN 4683 Proximity Label-MS Homo sapiens 56 DVL2 1856 Proximity Label-MS Homo sapiens 57 CCDC88A 55704 Proximity Label-MS Homo sapiens 58 EBAG9 9166 Proximity Label-MS Homo sapiens 59 FAM120A 23196 Proximity Label-MS Homo sapiens 60 GPR17 2840 Affinity Capture-MS Homo sapiens 61 MYL6 4637 Proximity Label-MS Homo sapiens 62 PCNA 5111 Proximity Label-MS Homo sapiens 63 ARHGEF11 9826 Proximity Label-MS Homo sapiens 64 YWHAB 7529 Affinity Capture-MS Homo sapiens 65 COBL   Proximity Label-MS Homo sapiens 66 GPATCH1   Proximity Label-MS Homo sapiens 67 SPAG5 10615 Proximity Label-MS Homo sapiens 68 BRPF1   Proximity Label-MS Homo sapiens 69 KRT34   Affinity Capture-MS Homo sapiens 70 ATG2A   Proximity Label-MS Homo sapiens 71 SCFD1 23256 Co-fractionation Homo sapiens 72 IFT27 11020 Proximity Label-MS Homo sapiens 73 CEP55 55165 Proximity Label-MS Homo sapiens 74 CAPZA1 829 Proximity Label-MS Homo sapiens 75 MRE11A 4361 Co-fractionation Homo sapiens 76 WASF2 10163 Proximity Label-MS Homo sapiens 77 LUZP1 7798 Proximity Label-MS Homo sapiens 78 WDR11 55717 Proximity Label-MS Homo sapiens 79 AASS   Proximity Label-MS Homo sapiens 80 CEP192 55125 Proximity Label-MS Homo sapiens 81 RAB21 23011 Proximity Label-MS Homo sapiens 82 LCTL   Affinity Capture-MS Homo sapiens 83 FAM9C   Affinity Capture-MS Homo sapiens 84 MAPRE1 22919 Affinity Capture-MS Homo sapiens 85 PNMA5 114824 Two-hybrid Homo sapiens 86 OSBPL3 26031 Proximity Label-MS Homo sapiens 87 ACACA 31 Proximity Label-MS Homo sapiens 88 COMTD1 118881 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 89 TUBB2B 347733 Proximity Label-MS Homo sapiens 90 MAPT   Reconstituted Complex Homo sapiens 91 PCCA 5095 Proximity Label-MS Homo sapiens 92 NTRK1 4914 Affinity Capture-MS Homo sapiens 93 PPARD   Affinity Capture-MS Homo sapiens 94 DCTN1 1639 Affinity Capture-Western Homo sapiens Proximity Label-MS Homo sapiens 95 MEOX2   Two-hybrid Homo sapiens 96 YWHAQ 10971 Proximity Label-MS Homo sapiens 97 MYH10 4628 Proximity Label-MS Homo sapiens 98 SDF4 51150 Affinity Capture-MS Homo sapiens 99 MTMR4   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 100 ACTG1 71 Proximity Label-MS Homo sapiens 101 PIPSL 266971 Affinity Capture-MS Homo sapiens 102 ABCB7 22 Proximity Label-MS Homo sapiens 103 SSX2IP   Proximity Label-MS Homo sapiens 104 ZNF326 284695 Proximity Label-MS Homo sapiens 105 TJP1 7082 Proximity Label-MS Homo sapiens 106 CD40 958 Affinity Capture-MS Homo sapiens 107 ZC4H2 55906 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 108 KIF1B 23095 Proximity Label-MS Homo sapiens 109 FAM160B1 57700 Proximity Label-MS Homo sapiens 110 WHAMMP3   Affinity Capture-MS Homo sapiens 111 AGBL4   Affinity Capture-MS Homo sapiens 112 HBS1L 10767 Proximity Label-MS Homo sapiens 113 TBKBP1   Proximity Label-MS Homo sapiens 114 NAP1L4 4676 Proximity Label-MS Homo sapiens 115 NCAPH2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 116 GCSH 2653 Co-fractionation Homo sapiens 117 IFT57 55081 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 118 CUL3 8452 Affinity Capture-MS Homo sapiens 119 TUBB4B 10383 Affinity Capture-MS Homo sapiens 120 CP 1356 Proximity Label-MS Homo sapiens 121 HOOK3 84376 Two-hybrid Homo sapiens Proximity Label-MS Homo sapiens Two-hybrid Homo sapiens Proximity Label-MS Homo sapiens 122 PPP6R2 9701 Proximity Label-MS Homo sapiens 123 TMEM74   Affinity Capture-MS Homo sapiens 124 KRT27 342574 Affinity Capture-MS Homo sapiens Two-hybrid Homo sapiens 125 HYOU1 10525 Proximity Label-MS Homo sapiens 126 HAUS5 23354 Proximity Label-MS Homo sapiens 127 ANKRD22   Affinity Capture-MS Homo sapiens 128 ANKRD52 283373 Proximity Label-MS Homo sapiens 129 PATL1 219988 Proximity Label-MS Homo sapiens 130 Eif3g 53356 Two-hybrid Mus musculus 131 TJP2 9414 Proximity Label-MS Homo sapiens 132 MYO6 4646 Proximity Label-MS Homo sapiens 133 DYNC1LI1 51143 Proximity Label-MS Homo sapiens Affinity Capture-MS Homo sapiens Proximity Label-MS Homo sapiens 134 VPS45 11311 Proximity Label-MS Homo sapiens 135 CTIF   Two-hybrid Homo sapiens 136 NAP1L1 4673 Proximity Label-MS Homo sapiens 137 FAM21C 253725 Proximity Label-MS Homo sapiens 138 NFKB1 4790 Proximity Label-MS Homo sapiens 139 NUBP1 4682 Affinity Capture-MS Homo sapiens 140 PPP6C 5537 Proximity Label-MS Homo sapiens 141 KLHL10   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 142 FEM1A   Affinity Capture-MS Homo sapiens 143 Nedd1   Affinity Capture-MS Mus musculus 144 PCM1 5108 Proximity Label-MS Homo sapiens 145 KIAA0319L 79932 Proximity Label-MS Homo sapiens 146 TNFSF13B   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 147 DUSP16   Affinity Capture-MS Homo sapiens 148 KRT19 3880 Proximity Label-MS Homo sapiens 149 AFTPH   Proximity Label-MS Homo sapiens 150 CCDC8   Affinity Capture-MS Homo sapiens 151 TPM3 7170 Proximity Label-MS Homo sapiens 152 MTHFD1L 25902 Proximity Label-MS Homo sapiens 153 SYNRG 11276 Proximity Label-MS Homo sapiens 154 MAGEA8   Affinity Capture-MS Homo sapiens 155 FTL 2512 Affinity Capture-MS Homo sapiens 156 RALBP1 10928 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 157 FAM160A2 84067 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Proximity Label-MS Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens 158 BSDC1 55108 Proximity Label-MS Homo sapiens 159 PLEC 5339 Proximity Label-MS Homo sapiens 160 KIAA0196 9897 Proximity Label-MS Homo sapiens 161 TP53 7157 Affinity Capture-MS Homo sapiens 162 TRIM52   Affinity Capture-MS Homo sapiens 163 MCM5 4174 Proximity Label-MS Homo sapiens 164 DUSP3 1845 Affinity Capture-MS Homo sapiens 165 BACH2 60468 Proximity Label-MS Homo sapiens 166 SIPA1L3   Proximity Label-MS Homo sapiens 167 CAPZB 832 Proximity Label-MS Homo sapiens 168 MAP7D3 79649 Proximity Label-MS Homo sapiens 169 RAD50 10111 Proximity Label-MS Homo sapiens 170 DYNC1H1 1778 Affinity Capture-Western Homo sapiens Proximity Label-MS Homo sapiens 171 SKAP1 8631 Affinity Capture-MS Homo sapiens 172 ABI2 10152 Proximity Label-MS Homo sapiens 173 FAM160A1   Affinity Capture-MS Homo sapiens Proximity Label-MS Homo sapiens Affinity Capture-MS Homo sapiens 174 GOLGA5 9950 Proximity Label-MS Homo sapiens 175 GAPVD1 26130 Proximity Label-MS Homo sapiens 176 PCCB 5096 Proximity Label-MS Homo sapiens 177 WDR83   Proximity Label-MS Homo sapiens 178 IGF2R 3482 Proximity Label-MS Homo sapiens 179 BCCIP 56647 Proximity Label-MS Homo sapiens 180 ACACB 32 Proximity Label-MS Homo sapiens 181 KRT13 3860 Two-hybrid Homo sapiens 182 SNX2 6643 Proximity Label-MS Homo sapiens 183 LTV1   Proximity Label-MS Homo sapiens 184 HLCS   Proximity Label-MS Homo sapiens 185 KIF1C 10749 Affinity Capture-MS Homo sapiens Proximity Label-MS Homo sapiens Affinity Capture-Western Homo sapiens 186 BCR 613 Proximity Label-MS Homo sapiens 187 DLD 1738 Proximity Label-MS Homo sapiens 188 PHF8   Proximity Label-MS Homo sapiens 189 FAM91A1 157769 Proximity Label-MS Homo sapiens 190 CC2D1A 54862 Proximity Label-MS Homo sapiens 191 FAM160B2 64760 Proximity Label-MS Homo sapiens View the network

Pathways in which HOOK3 is involved

No pathways found