Gene description for ZNF326
Gene name zinc finger protein 326
Gene symbol ZNF326
Other names/aliases ZAN75
ZIRD
Zfp326
dJ871E2.1
Species Homo sapiens
 Database cross references - ZNF326
ExoCarta ExoCarta_284695
Vesiclepedia VP_284695
Entrez Gene 284695
HGNC 14104
MIM 614601
UniProt Q5BKZ1  
 ZNF326 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for ZNF326
Molecular Function
    RNA polymerase II core binding GO:0000993 IDA
    zinc ion binding GO:0008270 IEA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
Biological Process
    regulation of DNA-templated transcription, elongation GO:0032784 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IEA
    RNA splicing GO:0008380 IMP
    mRNA processing GO:0006397 IEA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    spliceosomal complex GO:0005681 IDA
    DBIRD complex GO:0044609 IDA
    nucleoplasm GO:0005654 IDA
    nuclear matrix GO:0016363 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified ZNF326 in exosomes
1
Experiment ID 237
MISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Enriched markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 217
MISEV standards
EM
EV Biophysical techniques
TSG101|CD81|CD9|CD63
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ZNF326
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ZNF326 is involved
No pathways found





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