Gene description for Ybx1
Gene name Y box protein 1
Gene symbol Ybx1
Other names/aliases 1700102N10Rik
C79409
EF1A
MSY1
Nsep1
YB-1
dbpB
mYB-1a
Species Mus musculus
 Database cross references - Ybx1
ExoCarta ExoCarta_22608
Entrez Gene 22608
UniProt P62960  
 Ybx1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
Pancreatic cells 19351151    
 Gene ontology annotations for Ybx1
Molecular Function
    sequence-specific DNA binding GO:0043565 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    p53 binding GO:0002039 ISO
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
    RNA binding GO:0003723 ISO
    single-stranded DNA binding GO:0003697 ISO
    protein binding GO:0005515 IPI
    GTPase binding GO:0051020 ISO
    transcription factor binding GO:0008134 ISO
    mRNA binding GO:0003729 ISO
    nucleic acid binding GO:0003676 IEA
    DNA binding GO:0003677 ISO
    chromatin binding GO:0003682 IDA
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    negative regulation of apoptotic process GO:0043066 ISO
    transcription, DNA-templated GO:0006351 IEA
    transcription from RNA polymerase II promoter GO:0006366 ISO
    positive regulation of cell division GO:0051781 IEA
    negative regulation of striated muscle cell differentiation GO:0051154 IDA
    in utero embryonic development GO:0001701 IMP
    regulation of transcription, DNA-templated GO:0006355 ISO
    CRD-mediated mRNA stabilization GO:0070934 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    mRNA processing GO:0006397 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    RNA splicing GO:0008380 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    negative regulation of insulin receptor signaling pathway GO:0046627 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    histone pre-mRNA 3'end processing complex GO:0071204 IDA
    ribonucleoprotein complex GO:0030529 ISO
    cytoplasmic stress granule GO:0010494 ISO
    nucleus GO:0005634 ISO
    nuclear membrane GO:0031965 ISO
    dendrite GO:0030425 ISO
    CRD-mediated mRNA stability complex GO:0070937 ISO
    U12-type spliceosomal complex GO:0005689 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Ybx1 in exosomes
1
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ybx1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ybx1 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway IEA Reactome





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