Gene description for Ncbp1
Gene name nuclear cap binding protein subunit 1
Gene symbol Ncbp1
Other names/aliases AU014645
AW538051
CBP80
Species Mus musculus
 Database cross references - Ncbp1
ExoCarta ExoCarta_433702
Vesiclepedia VP_433702
Entrez Gene 433702
UniProt Q3UYV9  
 Ncbp1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ncbp1
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 ISO
    RNA binding GO:0003723 IEA
    RNA cap binding GO:0000339 IEA
Biological Process
    mRNA processing GO:0006397 IEA
    transport GO:0006810 IEA
    7-methylguanosine mRNA capping GO:0006370 ISO
    regulation of translation GO:0006417 IEA
    positive regulation of mRNA 3'-end processing GO:0031442 ISO
    mRNA transport GO:0051028 IEA
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 ISO
    gene silencing by RNA GO:0031047 IEA
    mRNA cleavage GO:0006379 ISO
    regulation of translational initiation GO:0006446 ISO
    mRNA export from nucleus GO:0006406 ISO
    RNA splicing GO:0008380 IEA
    RNA metabolic process GO:0016070 IEA
    mRNA cis splicing, via spliceosome GO:0045292 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    mRNA cap binding complex GO:0005845 ISO
    nuclear cap binding complex GO:0005846 ISO
    ribonucleoprotein complex GO:0030529 ISO
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Ncbp1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ncbp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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