Gene description for Atxn2
Gene name ataxin 2
Gene symbol Atxn2
Other names/aliases 9630045M23Rik
ATX2
AW544490
Sca2
Species Mus musculus
 Database cross references - Atxn2
ExoCarta ExoCarta_20239
Entrez Gene 20239
UniProt O70305  
 Atxn2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Atxn2
Molecular Function
    epidermal growth factor receptor binding GO:0005154 ISO
    protein C-terminus binding GO:0008022 ISO
    DBD domain binding GO:0050692 IDA
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    stress granule assembly GO:0034063 ISO
    regulation of cytoplasmic mRNA processing body assembly GO:0010603 IBA
    neuron projection morphogenesis GO:0048812 IMP
    cytoplasmic mRNA processing body assembly GO:0033962 ISO
    negative regulation of multicellular organism growth GO:0040015 IMP
    neuromuscular process GO:0050905 IMP
    negative regulation of receptor internalization GO:0002091 ISO
    homeostasis of number of cells GO:0048872 IMP
    cerebellar Purkinje cell differentiation GO:0021702 IMP
Subcellular Localization
    ribonucleoprotein complex GO:0030529 ISO
    cytoplasm GO:0005737 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    polysome GO:0005844 ISO
    trans-Golgi network GO:0005802 ISO
    cytoplasmic stress granule GO:0010494 ISO
    membrane GO:0016020 ISO
    Golgi apparatus GO:0005794 ISO
    nucleoplasm GO:0005654 ISO
 Experiment description of studies that identified Atxn2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Atxn2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atxn2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here