Gene description for Syncrip
Gene name synaptotagmin binding, cytoplasmic RNA interacting protein
Gene symbol Syncrip
Other names/aliases 2610109K23Rik
4632417O19Rik
GRY-RBP
Nsap1
Nsap1l
pp68
Species Mus musculus
 Database cross references - Syncrip
ExoCarta ExoCarta_56403
Vesiclepedia VP_56403
Entrez Gene 56403
UniProt Q7TMK9  
 Syncrip identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Syncrip
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    nucleotide binding GO:0000166 IEA
    poly(A) binding GO:0008143 IDA
    nucleic acid binding GO:0003676 IEA
    RNA binding GO:0003723 IEA
Biological Process
    negative regulation of translation GO:0017148 ISO
    mRNA processing GO:0006397 IEA
    osteoblast differentiation GO:0001649 ISO
    CRD-mediated mRNA stabilization GO:0070934 ISO
    RNA splicing GO:0008380 IEA
    cellular response to interferon-gamma GO:0071346 ISO
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 ISO
    membrane GO:0016020 ISO
    histone pre-mRNA 3'end processing complex GO:0071204 IDA
    cytoplasm GO:0005737 IDA
    CRD-mediated mRNA stability complex GO:0070937 ISO
    spliceosomal complex GO:0005681 IEA
    nucleus GO:0005634 IEA
    GAIT complex GO:0097452 ISO
    ribonucleoprotein complex GO:0030529 ISO
 Experiment description of studies that identified Syncrip in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Syncrip
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Syncrip is involved
No pathways found





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