Gene description for Hnrnpd
Gene name heterogeneous nuclear ribonucleoprotein D
Gene symbol Hnrnpd
Other names/aliases Auf1
Hnrpd
Species Mus musculus
 Database cross references - Hnrnpd
ExoCarta ExoCarta_11991
Vesiclepedia VP_11991
Entrez Gene 11991
UniProt Q60668  
 Hnrnpd identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hnrnpd
Molecular Function
    minor groove of adenine-thymine-rich DNA binding GO:0003680 IEA
    minor groove of adenine-thymine-rich DNA binding GO:0003680 ISO
    chromatin binding GO:0003682 IEA
    chromatin binding GO:0003682 ISO
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 ISO
    RNA binding GO:0003723 ISS
    mRNA binding GO:0003729 ISO
    protein binding GO:0005515 IPI
    mRNA 3'-UTR AU-rich region binding GO:0035925 IEA
    mRNA 3'-UTR AU-rich region binding GO:0035925 ISO
    telomeric DNA binding GO:0042162 ISO
    telomeric DNA binding GO:0042162 ISS
    histone deacetylase binding GO:0042826 IEA
    histone deacetylase binding GO:0042826 ISO
Biological Process
    liver development GO:0001889 IEA
    regulation of gene expression GO:0010468 IBA
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 ISO
    cerebellum development GO:0021549 IEA
    positive regulation of telomere maintenance via telomerase GO:0032212 IMP
    regulation of circadian rhythm GO:0042752 ISO
    regulation of circadian rhythm GO:0042752 ISS
    regulation of mRNA stability GO:0043488 IMP
    positive regulation of translation GO:0045727 ISO
    positive regulation of translation GO:0045727 ISS
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    response to calcium ion GO:0051592 IEA
    response to calcium ion GO:0051592 ISO
    response to electrical stimulus GO:0051602 IEA
    3'-UTR-mediated mRNA destabilization GO:0061158 IEA
    3'-UTR-mediated mRNA destabilization GO:0061158 ISO
    CRD-mediated mRNA stabilization GO:0070934 ISO
    cellular response to amino acid stimulus GO:0071230 IEA
    cellular response to estradiol stimulus GO:0071392 IEA
    cellular response to nitric oxide GO:0071732 IEA
    cellular response to nitric oxide GO:0071732 ISO
    circadian regulation of translation GO:0097167 ISO
    circadian regulation of translation GO:0097167 ISS
    negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900152 ISO
    response to rapamycin GO:1901355 IEA
    response to rapamycin GO:1901355 ISO
    positive regulation of telomere capping GO:1904355 IMP
    response to sodium phosphate GO:1904383 IEA
    response to sodium phosphate GO:1904383 ISO
    cellular response to putrescine GO:1904586 IEA
    cellular response to putrescine GO:1904586 ISO
    hepatocyte dedifferentiation GO:1990828 IEA
    positive regulation of cytoplasmic translation GO:2000767 ISO
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 ISO
    postsynaptic density GO:0014069 IEA
    postsynaptic density GO:0014069 ISO
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
    mCRD-mediated mRNA stability complex GO:0106002 ISO
    ribonucleoprotein complex GO:1990904 ISO
    ribonucleoprotein complex GO:1990904 ISS
 Experiment description of studies that identified Hnrnpd in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hnrnpd
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ago2 239528
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Stau1  
Co-fractionation Mus musculus
4 Ubc  
Reconstituted Complex Mus musculus
5 Tmem173  
Proximity Label-MS Mus musculus
6 Prmt5 27374
Biochemical Activity Mus musculus
7 Rps9 76846
Co-fractionation Mus musculus
8 Sdf2  
Co-fractionation Mus musculus
9 Eed  
Affinity Capture-MS Mus musculus
10 MKRN1 23608
Affinity Capture-MS Homo sapiens
11 Rpl13a 22121
Co-fractionation Mus musculus
12 Tfe3  
Affinity Capture-MS Mus musculus
13 Atg16l1  
Affinity Capture-MS Mus musculus
14 Ilf2 67781
Co-fractionation Mus musculus
15 Dmrt2  
Affinity Capture-MS Mus musculus
Reconstituted Complex Mus musculus
Affinity Capture-Western Mus musculus
16 Sra1  
Co-fractionation Mus musculus
17 Syncrip 56403
Co-fractionation Mus musculus
18 Fancd2  
Affinity Capture-MS Mus musculus
19 Cited4  
Two-hybrid Mus musculus
20 Ptbp2  
Co-fractionation Mus musculus
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