Gene description for Prmt5
Gene name protein arginine N-methyltransferase 5
Gene symbol Prmt5
Other names/aliases Jbp1
Species Mus musculus
 Database cross references - Prmt5
ExoCarta ExoCarta_27374
Entrez Gene 27374
UniProt Q8CIG8  
 Prmt5 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Prmt5
Molecular Function
    N-methyltransferase activity GO:0008170 IEA
    protein-arginine N5-methyltransferase activity GO:0019702 IEA
    C-methyltransferase activity GO:0008169 IEA
    hydroxyneurosporene-O-methyltransferase activity GO:0043803 IEA
    rRNA (uridine) methyltransferase activity GO:0016436 IEA
    methanol-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043851 IEA
    protein heterodimerization activity GO:0046982 ISO
    protein binding GO:0005515 IPI
    rRNA (cytosine-C5-)-methyltransferase activity GO:0009383 IEA
    dimethylamine methyltransferase activity GO:0043791 IEA
    demethylmenaquinone methyltransferase activity GO:0043770 IEA
    monomethylamine methyltransferase activity GO:0043852 IEA
    protein complex binding GO:0032403 ISO
    histone-arginine N-methyltransferase activity GO:0008469 IBA
    cobalt-precorrin-5B C1-methyltransferase activity GO:0043780 IEA
    protein-lysine N-methyltransferase activity GO:0016279 IEA
    tRNA methyltransferase activity GO:0008175 IEA
    trimethylamine methyltransferase activity GO:0043834 IEA
    cobalt-precorrin-7 C15-methyltransferase activity GO:0043777 IEA
    tRNA (adenine-57, 58-N(1)-) methyltransferase activity GO:0043827 IEA
    phosphomethylethanolamine N-methyltransferase activity GO:0052667 IEA
    protein-arginine N-methyltransferase activity GO:0016274 IEA
    chromatin binding GO:0003682 IMP
    tRNA (adenine-N1-)-methyltransferase activity GO:0016429 IEA
    selenocysteine methyltransferase activity GO:0016205 IEA
    tRNA (cytosine-3-)-methyltransferase activity GO:0052735 IEA
    transferase activity GO:0016740 IEA
    tRNA (cytosine-2'-O-)-methyltransferase activity GO:0052666 IEA
    protein-arginine omega-N symmetric methyltransferase activity GO:0035243 ISO
    S-methyltransferase activity GO:0008172 IEA
    core promoter sequence-specific DNA binding GO:0001046 IDA
    tRNA (cytosine-5-)-methyltransferase activity GO:0016428 IEA
    rRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179 IEA
    protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IEA
    rRNA (cytosine-N4-)-methyltransferase activity GO:0071424 IEA
    tRNA (guanine) methyltransferase activity GO:0016423 IEA
    tRNA (uracil) methyltransferase activity GO:0016300 IEA
    rRNA (guanine) methyltransferase activity GO:0016435 IEA
    protein methyltransferase activity GO:0008276 IEA
    tRNA (adenine) methyltransferase activity GO:0016426 IEA
    Se-methyltransferase activity GO:0051995 IEA
    rRNA (adenine) methyltransferase activity GO:0016433 IEA
    rRNA (cytosine) methyltransferase activity GO:0016434 IEA
    2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GO:0008425 IEA
    rRNA (cytosine-2'-O-)-methyltransferase activity GO:0070677 IEA
    DNA-methyltransferase activity GO:0009008 IEA
    1-hydroxy-6-methoxypyrene methyltransferase activity GO:0034933 IEA
    1-phenanthrol methyltransferase activity GO:0018707 IEA
    rRNA methyltransferase activity GO:0008649 IEA
    tRNA (guanine-N2-)-methyltransferase activity GO:0004809 IEA
    mRNA methyltransferase activity GO:0008174 IEA
    tRNA (cytosine) methyltransferase activity GO:0016427 IEA
    O-methyltransferase activity GO:0008171 IEA
    cobalt-precorrin-6B C5-methyltransferase activity GO:0043776 IEA
    cobalt-precorrin-3 C17-methyltransferase activity GO:0043782 IEA
    tRNA (guanine-N1-)-methyltransferase activity GO:0009019 IEA
    lysine N-methyltransferase activity GO:0016278 IEA
    RNA methyltransferase activity GO:0008173 IEA
    methylamine-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043833 IEA
    dimethylarsinite methyltransferase activity GO:0034541 IEA
    trihydroxyferuloyl spermidine O-methyltransferase activity GO:0080012 IEA
    4,5-dihydroxybenzo(a)pyrene methyltransferase activity GO:0034807 IEA
    rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IEA
    2-phytyl-1,4-naphthoquinone methyltransferase activity GO:0052624 IEA
    transcription corepressor activity GO:0003714 IMP
    protein C-terminal leucine carboxyl O-methyltransferase activity GO:0018423 IEA
    1-hydroxypyrene methyltransferase activity GO:0034931 IEA
    methylarsonite methyltransferase activity GO:0030792 IEA
    ribonucleoprotein complex binding GO:0043021 ISO
    tRNA (uracil-2'-O-)-methyltransferase activity GO:0052665 IEA
    rRNA (adenine-N6-)-methyltransferase activity GO:0008988 IEA
    methyltransferase activity GO:0008168 ISO
    P-methyltransferase activity GO:0051994 IEA
    arginine N-methyltransferase activity GO:0016273 IEA
Biological Process
    regulation of ERK1 and ERK2 cascade GO:0070372 ISO
    peptidyl-arginine methylation GO:0018216 ISO
    histone arginine methylation GO:0034969 IBA
    negative regulation of cell differentiation GO:0045596 ISO
    peptidyl-arginine methylation, to symmetrical-dimethyl arginine GO:0019918 ISO
    circadian regulation of gene expression GO:0032922 IMP
    rhythmic process GO:0048511 IEA
    spliceosomal snRNP assembly GO:0000387 ISO
    histone H4-R3 methylation GO:0043985 IMP
    chromatin modification GO:0016568 IEA
    protein methylation GO:0006479 ISO
    endothelial cell activation GO:0042118 ISO
    peptidyl-arginine N-methylation GO:0035246 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of DNA methylation GO:0044030 ISO
    positive regulation of oligodendrocyte differentiation GO:0048714 ISO
    methylation GO:0032259 IEA
Subcellular Localization
    nucleus GO:0005634 ISO
    methylosome GO:0034709 ISO
    cytoplasm GO:0005737 ISO
    protein complex GO:0043234 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Prmt5 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Prmt5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prmt5 is involved
RMTs methylate histone arginines IEA Reactome
snRNP Assembly IEA Reactome

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