Gene description for Prmt5
Gene name	protein arginine N-methyltransferase 5
Gene symbol	Prmt5
Other names/aliases	Jbp1 Skb1
Species	Mus musculus
Database cross references - Prmt5
ExoCarta	ExoCarta_27374
Entrez Gene	27374
UniProt	Q8CIG8
Prmt5 identified in exosomes derived from the following tissue/cell type
Fibroblasts	23260141

Gene ontology annotations for Prmt5

Molecular Function     N-methyltransferase activity GO:0008170 IEA     protein-arginine N5-methyltransferase activity GO:0019702 IEA     C-methyltransferase activity GO:0008169 IEA     hydroxyneurosporene-O-methyltransferase activity GO:0043803 IEA     rRNA (uridine) methyltransferase activity GO:0016436 IEA     methanol-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043851 IEA     protein heterodimerization activity GO:0046982 ISO     protein binding GO:0005515 IPI     rRNA (cytosine-C5-)-methyltransferase activity GO:0009383 IEA     dimethylamine methyltransferase activity GO:0043791 IEA     demethylmenaquinone methyltransferase activity GO:0043770 IEA     monomethylamine methyltransferase activity GO:0043852 IEA     protein complex binding GO:0032403 ISO     histone-arginine N-methyltransferase activity GO:0008469 IBA     cobalt-precorrin-5B C1-methyltransferase activity GO:0043780 IEA     protein-lysine N-methyltransferase activity GO:0016279 IEA     tRNA methyltransferase activity GO:0008175 IEA     trimethylamine methyltransferase activity GO:0043834 IEA     cobalt-precorrin-7 C15-methyltransferase activity GO:0043777 IEA     tRNA (adenine-57, 58-N(1)-) methyltransferase activity GO:0043827 IEA     phosphomethylethanolamine N-methyltransferase activity GO:0052667 IEA     protein-arginine N-methyltransferase activity GO:0016274 IEA     chromatin binding GO:0003682 IMP     tRNA (adenine-N1-)-methyltransferase activity GO:0016429 IEA     selenocysteine methyltransferase activity GO:0016205 IEA     tRNA (cytosine-3-)-methyltransferase activity GO:0052735 IEA     transferase activity GO:0016740 IEA     tRNA (cytosine-2'-O-)-methyltransferase activity GO:0052666 IEA     protein-arginine omega-N symmetric methyltransferase activity GO:0035243 ISO     S-methyltransferase activity GO:0008172 IEA     core promoter sequence-specific DNA binding GO:0001046 IDA     tRNA (cytosine-5-)-methyltransferase activity GO:0016428 IEA     rRNA (adenine-N6,N6-)-dimethyltransferase activity GO:0000179 IEA     protein C-terminal carboxyl O-methyltransferase activity GO:0003880 IEA     rRNA (cytosine-N4-)-methyltransferase activity GO:0071424 IEA     tRNA (guanine) methyltransferase activity GO:0016423 IEA     tRNA (uracil) methyltransferase activity GO:0016300 IEA     rRNA (guanine) methyltransferase activity GO:0016435 IEA     protein methyltransferase activity GO:0008276 IEA     tRNA (adenine) methyltransferase activity GO:0016426 IEA     Se-methyltransferase activity GO:0051995 IEA     rRNA (adenine) methyltransferase activity GO:0016433 IEA     rRNA (cytosine) methyltransferase activity GO:0016434 IEA     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GO:0008425 IEA     rRNA (cytosine-2'-O-)-methyltransferase activity GO:0070677 IEA     DNA-methyltransferase activity GO:0009008 IEA     1-hydroxy-6-methoxypyrene methyltransferase activity GO:0034933 IEA     1-phenanthrol methyltransferase activity GO:0018707 IEA     rRNA methyltransferase activity GO:0008649 IEA     tRNA (guanine-N2-)-methyltransferase activity GO:0004809 IEA     mRNA methyltransferase activity GO:0008174 IEA     tRNA (cytosine) methyltransferase activity GO:0016427 IEA     O-methyltransferase activity GO:0008171 IEA     cobalt-precorrin-6B C5-methyltransferase activity GO:0043776 IEA     cobalt-precorrin-3 C17-methyltransferase activity GO:0043782 IEA     tRNA (guanine-N1-)-methyltransferase activity GO:0009019 IEA     lysine N-methyltransferase activity GO:0016278 IEA     RNA methyltransferase activity GO:0008173 IEA     methylamine-specific methylcobalamin:coenzyme M methyltransferase activity GO:0043833 IEA     dimethylarsinite methyltransferase activity GO:0034541 IEA     trihydroxyferuloyl spermidine O-methyltransferase activity GO:0080012 IEA     4,5-dihydroxybenzo(a)pyrene methyltransferase activity GO:0034807 IEA     rRNA (uridine-2'-O-)-methyltransferase activity GO:0008650 IEA     2-phytyl-1,4-naphthoquinone methyltransferase activity GO:0052624 IEA     transcription corepressor activity GO:0003714 IMP     protein C-terminal leucine carboxyl O-methyltransferase activity GO:0018423 IEA     1-hydroxypyrene methyltransferase activity GO:0034931 IEA     methylarsonite methyltransferase activity GO:0030792 IEA     ribonucleoprotein complex binding GO:0043021 ISO     tRNA (uracil-2'-O-)-methyltransferase activity GO:0052665 IEA     rRNA (adenine-N6-)-methyltransferase activity GO:0008988 IEA     methyltransferase activity GO:0008168 ISO     P-methyltransferase activity GO:0051994 IEA     arginine N-methyltransferase activity GO:0016273 IEA Biological Process     regulation of ERK1 and ERK2 cascade GO:0070372 ISO     peptidyl-arginine methylation GO:0018216 ISO     histone arginine methylation GO:0034969 IBA     negative regulation of cell differentiation GO:0045596 ISO     peptidyl-arginine methylation, to symmetrical-dimethyl arginine GO:0019918 ISO     circadian regulation of gene expression GO:0032922 IMP     rhythmic process GO:0048511 IEA     spliceosomal snRNP assembly GO:0000387 ISO     histone H4-R3 methylation GO:0043985 IMP     chromatin modification GO:0016568 IEA     protein methylation GO:0006479 ISO     endothelial cell activation GO:0042118 ISO     peptidyl-arginine N-methylation GO:0035246 ISO     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     transcription, DNA-templated GO:0006351 IEA     regulation of transcription, DNA-templated GO:0006355 IEA     regulation of DNA methylation GO:0044030 ISO     positive regulation of oligodendrocyte differentiation GO:0048714 ISO     methylation GO:0032259 IEA Subcellular Localization     nucleus GO:0005634 ISO     methylosome GO:0034709 ISO     cytoplasm GO:0005737 ISO     protein complex GO:0043234 ISO     cytosol GO:0005829 ISO