Gene description for Snrpb
Gene name small nuclear ribonucleoprotein B
Gene symbol Snrpb
Other names/aliases AL024368
AU018828
SM-B
SM11
SMB
SNRNP-B
Species Mus musculus
 Database cross references - Snrpb
ExoCarta ExoCarta_20638
Vesiclepedia VP_20638
Entrez Gene 20638
UniProt P27048  
 Snrpb identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snrpb
Molecular Function
    RNA binding GO:0003723 ISO
    protein binding GO:0005515 IPI
    telomerase RNA binding GO:0070034 IEA
    telomerase RNA binding GO:0070034 ISO
    snRNP binding GO:0070990 IBA
    histone pre-mRNA DCP binding GO:0071208 IDA
    U1 snRNP binding GO:1990446 IEA
    U1 snRNP binding GO:1990446 ISO
    U2 snRNP binding GO:1990447 IEA
    U2 snRNP binding GO:1990447 ISO
Biological Process
    spliceosomal snRNP assembly GO:0000387 ISO
    spliceosomal snRNP assembly GO:0000387 ISS
    mRNA splicing, via spliceosome GO:0000398 IBA
    mRNA splicing, via spliceosome GO:0000398 ISO
    mRNA splicing, via spliceosome GO:0000398 ISS
    protein methylation GO:0006479 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    spliceosomal complex GO:0005681 ISO
    U5 snRNP GO:0005682 IBA
    U7 snRNP GO:0005683 ISO
    U7 snRNP GO:0005683 ISS
    U2-type spliceosomal complex GO:0005684 ISO
    U2-type spliceosomal complex GO:0005684 ISS
    U1 snRNP GO:0005685 IBA
    U1 snRNP GO:0005685 ISO
    U1 snRNP GO:0005685 ISS
    U2 snRNP GO:0005686 IBA
    U2 snRNP GO:0005686 IEA
    U2 snRNP GO:0005686 ISO
    U4 snRNP GO:0005687 IBA
    U4 snRNP GO:0005687 ISO
    U4 snRNP GO:0005687 ISS
    U12-type spliceosomal complex GO:0005689 IEA
    U12-type spliceosomal complex GO:0005689 ISO
    telomerase holoenzyme complex GO:0005697 IEA
    telomerase holoenzyme complex GO:0005697 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    methylosome GO:0034709 ISO
    methylosome GO:0034709 ISS
    SMN-Sm protein complex GO:0034719 ISO
    SMN-Sm protein complex GO:0034719 ISS
    U4/U6 x U5 tri-snRNP complex GO:0046540 IBA
    U4/U6 x U5 tri-snRNP complex GO:0046540 ISO
    U4/U6 x U5 tri-snRNP complex GO:0046540 ISS
    U2-type prespliceosome GO:0071004 IBA
    U2-type precatalytic spliceosome GO:0071005 ISO
    U2-type precatalytic spliceosome GO:0071005 ISS
    U2-type catalytic step 2 spliceosome GO:0071007 ISO
    U2-type catalytic step 2 spliceosome GO:0071007 ISS
    catalytic step 2 spliceosome GO:0071013 IBA
    catalytic step 2 spliceosome GO:0071013 ISO
    histone pre-mRNA 3'end processing complex GO:0071204 IDA
 Experiment description of studies that identified Snrpb in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snrpb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tia1  
Affinity Capture-MS Mus musculus
2 Prmt5 27374
Biochemical Activity Mus musculus
3 Elf5  
Affinity Capture-MS Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
5 Smn1 20595
Affinity Capture-Western Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here