Gene description for Snrpd2
Gene name small nuclear ribonucleoprotein D2
Gene symbol Snrpd2
Other names/aliases 1810009A06Rik
SMD2
Species Mus musculus
 Database cross references - Snrpd2
ExoCarta ExoCarta_107686
Vesiclepedia VP_107686
Entrez Gene 107686
UniProt P62317  
 Snrpd2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snrpd2
Molecular Function
    RNA binding GO:0003723 IEA
    U1 snRNP binding GO:1990446 ISO
Biological Process
    spliceosomal snRNP assembly GO:0000387 IBA
    spliceosomal snRNP assembly GO:0000387 ISO
    spliceosomal snRNP assembly GO:0000387 ISS
    mRNA splicing, via spliceosome GO:0000398 ISO
    mRNA splicing, via spliceosome GO:0000398 ISS
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    spliceosomal complex GO:0005681 ISO
    U5 snRNP GO:0005682 IBA
    U2-type spliceosomal complex GO:0005684 ISO
    U2-type spliceosomal complex GO:0005684 ISS
    U1 snRNP GO:0005685 IBA
    U1 snRNP GO:0005685 ISO
    U1 snRNP GO:0005685 ISS
    U2 snRNP GO:0005686 IBA
    U4 snRNP GO:0005687 ISO
    U4 snRNP GO:0005687 ISS
    U12-type spliceosomal complex GO:0005689 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    methylosome GO:0034709 ISO
    methylosome GO:0034709 ISS
    pICln-Sm protein complex GO:0034715 IBA
    pICln-Sm protein complex GO:0034715 ISO
    pICln-Sm protein complex GO:0034715 ISS
    SMN-Sm protein complex GO:0034719 ISO
    SMN-Sm protein complex GO:0034719 ISS
    U4/U6 x U5 tri-snRNP complex GO:0046540 IBA
    U4/U6 x U5 tri-snRNP complex GO:0046540 ISO
    U4/U6 x U5 tri-snRNP complex GO:0046540 ISS
    U2-type precatalytic spliceosome GO:0071005 ISO
    U2-type precatalytic spliceosome GO:0071005 ISS
    U2-type catalytic step 2 spliceosome GO:0071007 ISO
    U2-type catalytic step 2 spliceosome GO:0071007 ISS
    precatalytic spliceosome GO:0071011 IBA
    catalytic step 2 spliceosome GO:0071013 IBA
    catalytic step 2 spliceosome GO:0071013 ISO
 Experiment description of studies that identified Snrpd2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snrpd2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sf3a3 75062
Co-fractionation Mus musculus
2 Stxbp3 20912
Co-fractionation Mus musculus
3 Mdm2  
Affinity Capture-MS Mus musculus
4 Prpf8 192159
Co-fractionation Mus musculus
5 Prmt5 27374
Co-fractionation Mus musculus
6 Prpf3 70767
Co-fractionation Mus musculus
7 Snrpd1 20641
Co-fractionation Mus musculus
8 Strap 20901
Co-fractionation Mus musculus
9 Lsm6  
Co-fractionation Mus musculus
10 Cdc5l 71702
Co-fractionation Mus musculus
11 Plrg1  
Co-fractionation Mus musculus
12 Snrpe 20643
Co-fractionation Mus musculus
13 Ybx1 22608
Co-fractionation Mus musculus
14 Atxn1  
Affinity Capture-MS Mus musculus
15 Kctd13  
Affinity Capture-MS Mus musculus
16 Snrnp200 320632
Co-fractionation Mus musculus
17 Snrpd3 67332
Co-fractionation Mus musculus
18 Ppp1ca 19045
Co-fractionation Mus musculus
19 Sf3b3 101943
Co-fractionation Mus musculus
20 Ptprz1  
Affinity Capture-MS Mus musculus
21 Hnrnph1 59013
Co-fractionation Mus musculus
22 Tmem173  
Proximity Label-MS Mus musculus
23 Lsm3  
Co-fractionation Mus musculus
24 Ppie  
Co-fractionation Mus musculus
25 Pabpc1 18458
Co-fractionation Mus musculus
26 Srrm2  
Co-fractionation Mus musculus
27 Puf60 67959
Co-fractionation Mus musculus
28 Syncrip 56403
Co-fractionation Mus musculus
29 Snw1  
Co-fractionation Mus musculus
30 Ppwd1  
Co-fractionation Mus musculus
31 Sfpq 71514
Co-fractionation Mus musculus
32 Dhx15 13204
Co-fractionation Mus musculus
33 Fancd2  
Affinity Capture-MS Mus musculus
34 Hnrnpk 15387
Co-fractionation Mus musculus
35 Stxbp2 20911
Co-fractionation Mus musculus
36 Cwc27  
Co-fractionation Mus musculus
37 U2af2 22185
Co-fractionation Mus musculus
38 Mapt  
Affinity Capture-MS Mus musculus
39 Prpf31  
Co-fractionation Mus musculus
40 Lgals1 16852
Co-fractionation Mus musculus
41 Eftud2 20624
Co-fractionation Mus musculus
42 Hnrnpa2b1 53379
Co-fractionation Mus musculus
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