Gene description for Stxbp2
Gene name syntaxin binding protein 2
Gene symbol Stxbp2
Other names/aliases C79054
Munc-18-2
Munc-18b
Munc18b
Sxtbp2
Sxtp2
Unc18-2
Unc18b
muSec1
Species Mus musculus
 Database cross references - Stxbp2
ExoCarta ExoCarta_20911
Entrez Gene 20911
UniProt Q64324  
 Stxbp2 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Stxbp2
Molecular Function
    syntaxin binding GO:0019905 TAS
    syntaxin-1 binding GO:0017075 ISO
    syntaxin-3 binding GO:0030348 ISO
Biological Process
    leukocyte mediated cytotoxicity GO:0001909 ISO
    vesicle-mediated transport GO:0016192 IEA
    regulation of mast cell degranulation GO:0043304 ISO
    protein transport GO:0015031 IEA
    vesicle docking involved in exocytosis GO:0006904 IEA
    exocytosis GO:0006887 IMP
    transport GO:0006810 IEA
Subcellular Localization
    protein complex GO:0043234 ISO
    cell GO:0005623 IMP
    lamellipodium GO:0030027 ISO
    cytosol GO:0005829 ISO
    apical plasma membrane GO:0016324 ISO
    extracellular exosome GO:0070062 ISO
    SNARE complex GO:0031201 ISO
    azurophil granule GO:0042582 ISO
    tertiary granule GO:0070820 ISO
    plasma membrane GO:0005886 ISO
    cytolytic granule GO:0044194 ISO
    secretory granule GO:0030141 ISO
    specific granule GO:0042581 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Stxbp2 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Stxbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Stxbp2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here