Gene description for Pld2
Gene name phospholipase D2
Gene symbol Pld2
Other names/aliases PLD1C
Species Mus musculus
 Database cross references - Pld2
ExoCarta ExoCarta_18806
Entrez Gene 18806
UniProt P97813  
 Pld2 identified in exosomes derived from the following tissue/cell type
Basophilic leukemia cells 20424270    
 Gene ontology annotations for Pld2
Molecular Function
    protein kinase C binding GO:0005080 ISO
    N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290 IEA
    hydrolase activity GO:0016787 IEA
    phospholipase D activity GO:0004630 ISO
    catalytic activity GO:0003824 IEA
    phosphatidylinositol binding GO:0035091 IEA
Biological Process
    response to organic cyclic compound GO:0014070 ISO
    phospholipid catabolic process GO:0009395 ISO
    positive regulation of mast cell degranulation GO:0043306 ISO
    regulation of cell migration GO:0030334 IEA
    lipid catabolic process GO:0016042 IEA
    receptor-mediated endocytosis GO:0006898 IDA
    G-protein coupled receptor internalization GO:0002031 IDA
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISO
    response to hypoxia GO:0001666 ISO
    positive regulation of cell adhesion GO:0045785 ISO
    neuron projection development GO:0031175 ISO
    response to peptide hormone GO:0043434 ISO
    inositol lipid-mediated signaling GO:0048017 IEA
    response to hydrogen peroxide GO:0042542 ISO
    phosphatidic acid biosynthetic process GO:0006654 IEA
    regulation of phagocytosis GO:0050764 IEA
    positive regulation of receptor-mediated endocytosis GO:0048260 ISO
    lipid metabolic process GO:0006629 IEA
Subcellular Localization
    caveola GO:0005901 ISO
    plasma membrane GO:0005886 ISO
    sarcolemma GO:0042383 ISO
    Golgi apparatus GO:0005794 ISO
    brush border membrane GO:0031526 IDA
    membrane GO:0016020 IEA
    nucleus GO:0005634 ISO
    lamellipodium GO:0030027 ISO
 Experiment description of studies that identified Pld2 in exosomes
Experiment ID 89
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 20424270    
Organism Rattus norvegicus
Experiment description Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.
Authors Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S, Poirot M, Record M.
Journal name JLR
Publication year 2010
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Gas chromatography
Thin layer chromatography
Mass spectrometry [Qstar XL]
 Protein-protein interactions for Pld2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pld2 is involved
Role of phospholipids in phagocytosis IEA Reactome
Synthesis of PA IEA Reactome
Synthesis of PG IEA Reactome

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