Gene description for Lgals1
Gene name lectin, galactose binding, soluble 1
Gene symbol Lgals1
Other names/aliases AA410090
Species Mus musculus
 Database cross references - Lgals1
ExoCarta ExoCarta_16852
Entrez Gene 16852
UniProt P16045  
 Lgals1 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Lgals1
Molecular Function
    signal transducer activity GO:0004871 ISO
    protein binding GO:0005515 IPI
    glycoprotein binding GO:0001948 ISO
    galactoside binding GO:0016936 IEA
    lactose binding GO:0030395 ISO
    carbohydrate binding GO:0030246 IDA
    protein homodimerization activity GO:0042803 ISO
    laminin binding GO:0043236 ISO
    galactose binding GO:0005534 NAS
    poly(A) RNA binding GO:0044822 ISO
Biological Process
    apoptotic process GO:0006915 IEA
    negative regulation of cell-substrate adhesion GO:0010812 ISO
    positive regulation of erythrocyte aggregation GO:0034120 ISO
    signal transduction GO:0007165 ISO
    negative regulation of neuron projection development GO:0010977 ISO
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 NAS
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
    plasma cell differentiation GO:0002317 IDA
    T cell costimulation GO:0031295 IDA
    myoblast differentiation GO:0045445 IDA
Subcellular Localization
    extracellular space GO:0005615 ISO
    cell surface GO:0009986 ISO
    extracellular region GO:0005576 IEA
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular matrix GO:0031012 ISO
    nucleus GO:0005634 ISO
    intracellular GO:0005622 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Lgals1 in exosomes
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lgals1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lgals1 is involved
No pathways found

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