ExoCarta: Gene summary

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Gene description for Snrpe
Gene name	small nuclear ribonucleoprotein E
Gene symbol	Snrpe
Other names/aliases	AL022645 C76690 SME
Species	Mus musculus
Database cross references - Snrpe
ExoCarta	ExoCarta_20643
Entrez Gene	20643
UniProt	P62305
Snrpe identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Snrpe

Molecular Function
	RNA binding	GO:0003723	IEA
Biological Process
	mRNA processing	GO:0006397	IEA
	RNA splicing	GO:0008380	IEA
	spliceosomal snRNP assembly	GO:0000387	IBA
	mRNA splicing, via spliceosome	GO:0000398	IEA
Subcellular Localization
	cytoplasm	GO:0005737	IEA
	ribonucleoprotein complex	GO:0030529	IEA
	U4/U6 x U5 tri-snRNP complex	GO:0046540	IBA
	U5 snRNP	GO:0005682	IBA
	U4 snRNP	GO:0005687	IBA
	precatalytic spliceosome	GO:0071011	IBA
	nucleus	GO:0005634	IEA
	U2 snRNP	GO:0005686	IBA
	U1 snRNP	GO:0005685	IBA
	spliceosomal complex	GO:0005681	IEA

Experiment description of studies that identified Snrpe in exosomes

Experiment ID

ISEV standards
✔ EM	EV Biophysical techniques
✘	EV Cytosolic markers
✔ CD63	EV Membrane markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

17486113

Organism

Mus musculus
Homo sapiens

Experiment description

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.

Authors

Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO

Journal name

NCB

Publication year

2007

Sample

Mast cells

Sample name

MC9
Bone marrow-derived mast cells
HMC-1

Isolation/purification methods

Filtration
Ultracentrifugation
Sucrose density gradient

Flotation density

1.11-1.21 g/mL

Molecules identified in the study

Protein
mRNA
miRNA

Methods used in the study

Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array