Gene description for Sfpq
Gene name splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
Gene symbol Sfpq
Other names/aliases 1110004P21Rik
2810416M14Rik
5730453G22Rik
9030402K04Rik
AU021830
D4Ertd314e
Gm12940
OTTMUSG00000009329
PSF
REP1
Species Mus musculus
 Database cross references - Sfpq
ExoCarta ExoCarta_71514
Entrez Gene 71514
UniProt Q8VIJ6  
 Sfpq identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Pancreatic cells 19351151    
 Gene ontology annotations for Sfpq
Molecular Function
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 ISO
    transcription regulatory region DNA binding GO:0044212 ISO
    DNA binding GO:0003677 IEA
    core promoter binding GO:0001047 IDA
    protein binding GO:0005515 IPI
    nucleic acid binding GO:0003676 IEA
    transcription regulatory region sequence-specific DNA binding GO:0000976 IDA
    histone deacetylase binding GO:0042826 ISO
    RNA binding GO:0003723 IEA
Biological Process
    negative regulation of circadian rhythm GO:0042754 IMP
    DNA repair GO:0006281 IEA
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    regulation of cell cycle GO:0051726 IMP
    mRNA processing GO:0006397 IEA
    cellular response to DNA damage stimulus GO:0006974 IMP
    rhythmic process GO:0048511 IEA
    double-strand break repair via homologous recombination GO:0000724 ISO
    negative regulation of transcription, DNA-templated GO:0045892 IMP
    alternative mRNA splicing, via spliceosome GO:0000380 ISO
    regulation of circadian rhythm GO:0042752 IMP
    RNA splicing GO:0008380 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    chromosome organization GO:0051276 IMP
    histone H3 deacetylation GO:0070932 IMP
    positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 ISO
    positive regulation of sister chromatid cohesion GO:0045876 IMP
Subcellular Localization
    nuclear matrix GO:0016363 ISO
    chromatin GO:0000785 ISO
    nucleoplasm GO:0005654 ISO
    paraspeckles GO:0042382 ISO
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Sfpq in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sfpq
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sfpq is involved
No pathways found





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