Gene description for Ago2
Gene name	argonaute RISC catalytic subunit 2
Gene symbol	Ago2
Other names/aliases	1110029L17Rik 2310051F07Rik AI225898 AL022874 AW546247 ENSMUSG00000072493 Eif2c2 Gerp95 Gm10365 mKIAA4215
Species	Mus musculus
Database cross references - Ago2
ExoCarta	ExoCarta_239528
Entrez Gene	239528
UniProt	Q8CJG0
Ago2 identified in exosomes derived from the following tissue/cell type
Neural stem cells	25242146

Gene ontology annotations for Ago2

Molecular Function     RNA 7-methylguanosine cap binding GO:0000340 ISO     metal ion binding GO:0046872 IEA     RNA polymerase II core binding GO:0000993 ISO     endoribonuclease activity GO:0004521 ISO     endoribonuclease activity, cleaving miRNA-paired mRNA GO:0090624 ISO     single-stranded RNA binding GO:0003727 ISO     pre-miRNA binding GO:0070883 ISO     nucleic acid binding GO:0003676 IEA     RNA binding GO:0003723 IDA     endonuclease activity GO:0004519 IEA     protein binding GO:0005515 IPI     double-stranded RNA binding GO:0003725 ISO     core promoter binding GO:0001047 ISO     nuclease activity GO:0004518 IEA     miRNA binding GO:0035198 ISO     endoribonuclease activity, cleaving siRNA-paired mRNA GO:0070551 ISO     hydrolase activity GO:0016787 IEA     mRNA binding GO:0003729 IDA     poly(A) RNA binding GO:0044822 ISO     siRNA binding GO:0035197 ISO Biological Process     siRNA loading onto RISC involved in RNA interference GO:0035087 ISO     positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 IMP     RNA secondary structure unwinding GO:0010501 ISO     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO     positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 IMP     negative regulation of translation involved in gene silencing by miRNA GO:0035278 ISO     mRNA cleavage involved in gene silencing by miRNA GO:0035279 ISO     positive regulation of gene expression GO:0010628 IMP     gene silencing by RNA GO:0031047 IMP     pre-miRNA processing GO:0031054 ISO     miRNA loading onto RISC involved in gene silencing by miRNA GO:0035280 ISO     cell differentiation GO:0030154 IEA     mRNA cleavage GO:0006379 IMP     negative regulation of translational initiation GO:0045947 ISO     mRNA cleavage involved in gene silencing by siRNA GO:0090625 ISO     post-embryonic development GO:0009791 IMP     regulation of translation GO:0006417 IEA     regulation of transcription, DNA-templated GO:0006355 IEA     multicellular organismal development GO:0007275 IEA     transcription, DNA-templated GO:0006351 IEA     production of miRNAs involved in gene silencing by miRNA GO:0035196 ISO     miRNA metabolic process GO:0010586 IDA     RNA phosphodiester bond hydrolysis, endonucleolytic GO:0090502 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     nucleus GO:0005634 IDA     dendrite GO:0030425 IDA     RISC complex GO:0016442 ISO     cytosol GO:0005829 IDA     ribonucleoprotein complex GO:0030529 ISO     RISC-loading complex GO:0070578 ISO     mRNA cap binding complex GO:0005845 ISO     cytoplasmic mRNA processing body GO:0000932 ISO     membrane GO:0016020 ISO     micro-ribonucleoprotein complex GO:0035068 ISO     polysome GO:0005844 ISO