Gene description for Ago2
Gene name	argonaute RISC catalytic subunit 2
Gene symbol	Ago2
Other names/aliases	1110029L17Rik 2310051F07Rik AI225898 AL022874 AW546247 ENSMUSG00000072493 Eif2c2 Gerp95 Gm10365 mKIAA4215
Species	Mus musculus
Database cross references - Ago2
ExoCarta	ExoCarta_239528
Vesiclepedia	VP_239528
Entrez Gene	239528
UniProt	Q8CJG0
Ago2 identified in exosomes derived from the following tissue/cell type
Neural stem cells	25242146

Gene ontology annotations for Ago2

Molecular Function     RNA 7-methylguanosine cap binding GO:0000340 ISO     RNA 7-methylguanosine cap binding GO:0000340 ISS     RNA polymerase II complex binding GO:0000993 IEA     RNA polymerase II complex binding GO:0000993 ISO     core promoter sequence-specific DNA binding GO:0001046 IEA     core promoter sequence-specific DNA binding GO:0001046 ISO     RNA binding GO:0003723 IDA     double-stranded RNA binding GO:0003725 IEA     double-stranded RNA binding GO:0003725 ISO     single-stranded RNA binding GO:0003727 IBA     single-stranded RNA binding GO:0003727 IEA     single-stranded RNA binding GO:0003727 ISO     mRNA binding GO:0003729 IDA     RNA endonuclease activity GO:0004521 IBA     RNA endonuclease activity GO:0004521 IDA     RNA endonuclease activity GO:0004521 ISO     protein binding GO:0005515 IPI     Hsp70 protein binding GO:0030544 ISO     siRNA binding GO:0035197 ISO     siRNA binding GO:0035197 ISO     siRNA binding GO:0035197 ISS     miRNA binding GO:0035198 IBA     miRNA binding GO:0035198 IDA     miRNA binding GO:0035198 IMP     miRNA binding GO:0035198 ISO     mRNA 3'-UTR AU-rich region binding GO:0035925 IEA     mRNA 3'-UTR AU-rich region binding GO:0035925 ISO     metal ion binding GO:0046872 IEA     Hsp90 protein binding GO:0051879 ISO     endoribonuclease activity, cleaving siRNA-paired mRNA GO:0070551 ISO     endoribonuclease activity, cleaving siRNA-paired mRNA GO:0070551 ISS     endoribonuclease activity, cleaving siRNA-paired mRNA GO:0070551 TAS     endoribonuclease activity, cleaving miRNA-paired mRNA GO:0090624 IEA     endoribonuclease activity, cleaving miRNA-paired mRNA GO:0090624 ISO     mRNA cap binding GO:0098808 ISO     mRNA cap binding GO:0098808 ISS     RISC complex binding GO:1905172 ISO Biological Process     post-embryonic development GO:0009791 IMP     RNA secondary structure unwinding GO:0010501 IEA     RNA secondary structure unwinding GO:0010501 ISO     miRNA metabolic process GO:0010586 IDA     positive regulation of gene expression GO:0010628 IMP     cell differentiation GO:0030154 IEA     siRNA processing GO:0030422 ISO     regulatory ncRNA-mediated gene silencing GO:0031047 IMP     pre-miRNA processing GO:0031054 IBA     pre-miRNA processing GO:0031054 IDA     pre-miRNA processing GO:0031054 ISO     pre-miRNA processing GO:0031054 ISS     P-body assembly GO:0033962 IEA     P-body assembly GO:0033962 ISO     regulatory ncRNA-mediated post-transcriptional gene silencing GO:0035194 IBA     miRNA processing GO:0035196 IMP     miRNA processing GO:0035196 ISO     miRNA-mediated gene silencing by inhibition of translation GO:0035278 ISO     miRNA-mediated gene silencing by inhibition of translation GO:0035278 ISS     miRNA-mediated gene silencing by mRNA destabilization GO:0035279 IDA     miRNA-mediated gene silencing by mRNA destabilization GO:0035279 ISO     miRNA-mediated gene silencing by mRNA destabilization GO:0035279 ISS     negative regulation of amyloid precursor protein biosynthetic process GO:0042985 ISO     regulation of mRNA stability GO:0043488 ISO     positive regulation of translation GO:0045727 IEA     positive regulation of translation GO:0045727 ISO     positive regulation of angiogenesis GO:0045766 IEA     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     negative regulation of translational initiation GO:0045947 ISO     negative regulation of translational initiation GO:0045947 ISS     positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 IMP     RISC complex assembly GO:0070922 ISO     regulation of synapse maturation GO:0090128 IEA     regulation of synapse maturation GO:0090128 ISO     siRNA-mediated gene silencing by mRNA destabilization GO:0090625 IEA     siRNA-mediated gene silencing by mRNA destabilization GO:0090625 ISO     positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 IMP     positive regulation of post-transcriptional gene silencing by RNA GO:1900370 ISO     positive regulation of trophoblast cell migration GO:1901165 IEA     positive regulation of trophoblast cell migration GO:1901165 ISO Subcellular Localization     P-body GO:0000932 IDA     P-body GO:0000932 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     mitochondrion GO:0005739 ISO     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 IDA     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     cytoplasmic stress granule GO:0010494 ISO     membrane GO:0016020 ISO     RISC complex GO:0016442 IBA     RISC complex GO:0016442 IDA     RISC complex GO:0016442 ISO     RISC complex GO:0016442 ISS     dendrite GO:0030425 IDA     dendrite GO:0030425 ISO     chromatoid body GO:0033391 ISO     cytoplasmic ribonucleoprotein granule GO:0036464 IBA     cytoplasmic ribonucleoprotein granule GO:0036464 ISO     P granule GO:0043186 ISO     extracellular exosome GO:0070062 IEA     extracellular exosome GO:0070062 ISO     RISC-loading complex GO:0070578 IDA     RISC-loading complex GO:0070578 IPI     RISC-loading complex GO:0070578 ISO     RISC-loading complex GO:0070578 ISS     pi-body GO:0071546 ISO     postsynapse GO:0098794 IEA     postsynapse GO:0098794 ISO     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO     ribonucleoprotein complex GO:1990904 IDA     ribonucleoprotein complex GO:1990904 ISO