Gene description for Cbl
Gene name Casitas B-lineage lymphoma
Gene symbol Cbl
Other names/aliases 4732447J05Rik
Cbl-2
c-Cbl
cbl
Species Mus musculus
 Database cross references - Cbl
ExoCarta ExoCarta_12402
Vesiclepedia VP_12402
Entrez Gene 12402
UniProt P22682  
 Cbl identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cbl
Molecular Function
    ligase activity GO:0016874 IEA
    protein-glycine ligase activity, elongating GO:0070737 IEA
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GO:0008766 IEA
    tubulin-glutamic acid ligase activity GO:0070740 IEA
    signal transducer activity GO:0004871 IEA
    coenzyme F420-2 alpha-glutamyl ligase activity GO:0043774 IEA
    protein-glycine ligase activity GO:0070735 IEA
    protein-glycine ligase activity, initiating GO:0070736 IEA
    tubulin-glycine ligase activity GO:0070738 IEA
    calcium ion binding GO:0005509 IEA
    ephrin receptor binding GO:0046875 ISO
    SH3 domain binding GO:0017124 ISO
    protein-glutamic acid ligase activity GO:0070739 IEA
    phosphotyrosine binding GO:0001784 IEA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    ubiquitin-protein transferase activity GO:0004842 IEA
    zinc ion binding GO:0008270 IEA
    ribosomal S6-glutamic acid ligase activity GO:0018169 IEA
    coenzyme F420-0 gamma-glutamyl ligase activity GO:0043773 IEA
Biological Process
    regulation of signaling GO:0023051 IEA
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    cell surface receptor signaling pathway GO:0007166 IEA
Subcellular Localization
    plasma membrane GO:0005886 ISO
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 ISO
    flotillin complex GO:0016600 IDA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Cbl in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cbl
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Grb2 14784
Affinity Capture-Western Mus musculus
2 Lck 16818
Affinity Capture-Western Mus musculus
3 Pik3r1  
Affinity Capture-Western Mus musculus
View the network image/svg+xml



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