Gene description for Pdgfrb
Gene name platelet derived growth factor receptor, beta polypeptide
Gene symbol Pdgfrb
Other names/aliases AI528809
Species Mus musculus
 Database cross references - Pdgfrb
ExoCarta ExoCarta_18596
Entrez Gene 18596
UniProt P05622  
 Pdgfrb identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Pdgfrb
Molecular Function
    ATP binding GO:0005524 IEA
    protein kinase activity GO:0004672 IEA
    transferase activity GO:0016740 IEA
    protein tyrosine kinase activity GO:0004713 ISO
    vascular endothelial growth factor binding GO:0038085 ISO
    platelet-derived growth factor-activated receptor activity GO:0005017 ISO
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    nucleotide binding GO:0000166 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 ISO
    protein kinase binding GO:0019901 ISO
    kinase activity GO:0016301 IMP
    receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    platelet-derived growth factor receptor binding GO:0005161 ISO
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA
    signal transducer activity GO:0004871 IDA
    phosphatidylinositol 3-kinase binding GO:0043548 ISO
    platelet-derived growth factor binding GO:0048407 TAS
Biological Process
    positive regulation of MAP kinase activity GO:0043406 IDA
    phosphatidylinositol metabolic process GO:0046488 ISO
    phosphatidylinositol-mediated signaling GO:0048015 ISO
    smooth muscle tissue development GO:0048745 IMP
    skeletal system morphogenesis GO:0048705 IMP
    positive regulation of reactive oxygen species metabolic process GO:2000379 IMP
    nitrogen compound metabolic process GO:0006807 IMP
    aorta morphogenesis GO:0035909 IGI
    intracellular signal transduction GO:0035556 ISO
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 ISO
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA
    phosphorylation GO:0016310 IMP
    chemotaxis GO:0006935 IEA
    positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 ISO
    hemopoiesis GO:0030097 IMP
    positive regulation of collagen biosynthetic process GO:0032967 ISO
    positive regulation of phosphoprotein phosphatase activity GO:0032516 ISO
    signal transduction GO:0007165 ISO
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 IMP
    protein phosphorylation GO:0006468 IEA
    negative regulation of apoptotic process GO:0043066 ISO
    smooth muscle cell chemotaxis GO:0071670 IGI
    tissue homeostasis GO:0001894 IMP
    positive regulation of mitotic nuclear division GO:0045840 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    retina vasculature development in camera-type eye GO:0061298 IMP
    metanephric glomerular capillary formation GO:0072277 IGI
    multicellular organismal development GO:0007275 IEA
    positive regulation of cell proliferation GO:0008284 ISO
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    cell migration GO:0016477 ISO
    positive regulation of calcium ion import GO:0090280 IMP
    cell chemotaxis GO:0060326 ISO
    positive regulation of phospholipase C activity GO:0010863 ISO
    positive regulation of chemotaxis GO:0050921 IDA
    cell migration involved in coronary angiogenesis GO:0060981 IMP
    positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 IMP
    cell migration involved in vasculogenesis GO:0035441 IMP
    adrenal gland development GO:0030325 IGI
    cellular response to platelet-derived growth factor stimulus GO:0036120 ISO
    in utero embryonic development GO:0001701 IMP
    positive regulation of smooth muscle cell proliferation GO:0048661 ISO
    positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISO
    regulation of actin cytoskeleton organization GO:0032956 IGI
    metanephric mesenchymal cell migration GO:0035789 ISO
    kidney development GO:0001822 IMP
    cardiac myofibril assembly GO:0055003 IGI
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IDA
    platelet-derived growth factor receptor signaling pathway GO:0048008 ISO
    positive regulation of cell migration GO:0030335 ISO
    cardiac vascular smooth muscle cell differentiation GO:0060947 TAS
    positive regulation of DNA biosynthetic process GO:2000573 IMP
    metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 IMP
    peptidyl-tyrosine phosphorylation GO:0018108 ISO
    glycosaminoglycan biosynthetic process GO:0006024 ISO
    protein autophosphorylation GO:0046777 ISO
Subcellular Localization
    lysosome GO:0005764 IEA
    plasma membrane GO:0005886 ISO
    nucleus GO:0005634 ISO
    focal adhesion GO:0005925 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasmic vesicle GO:0031410 IEA
    apical plasma membrane GO:0016324 ISO
    intrinsic component of plasma membrane GO:0031226 ISO
    cell surface GO:0009986 IDA
    cytoplasm GO:0005737 ISO
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 ISO
 Experiment description of studies that identified Pdgfrb in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pdgfrb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pdgfrb is involved
No pathways found

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